Common name: DINOTEFURAN

Type: Pesticide or veterinary medicine, depending on usage
Chemical class: neonicotinoid

CHEMICAL STRUCTURE

Molecular structure of DINOTEFURAN

 

 

 

 

 

 


EFFICACY AGAINST PARASITES

Type of action: Contact, non-systemic insecticide
Main veterinary parasites controlled: fleashouseflies and other nuisance flies

Efficacy against a specific parasite depends on the delivery form and on the dose administered.

Click here for general information on features and characteristics of PARASITICIDES.


DOSING

Dosing recommendations for antiparasitics depend on national regulations. National regulatory authorities determine whether a product is approved for a given indication, i.e. use on a particular host at a specific dose and against a specific parasiteCheck the labels of the products available in your country for specific information on approved indications.

The table below indicates some usual dosing recommendations for dinotefuran issued by manufacturers or documented in the scientific literature. They may not be approved in some countries.

Dinotefuran is a contact insecticide without systemic effect that belongs to the chemical class of the neonicotinoids. It is highly effective against fleas but not against ticks or mites, or any internal parasites. It is often used in combination with a tickicide/acaricide (e.g. permethrin) or with an insect growth regulator (e.g. pyriproxyfen). So far it is not used in livestock or horses.

Dosing recommendations for DINOTEFURAN
Delivery Parasites Dose (against dinotefuran-susceptible parasites)
DOGS
Spot-on Fleas 6.3 - 28.8 mg/kg, depending on animal's weight
CATS
Spot-on Fleas 49.3 - 705 mg/kg, depending on animal's weight

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SAFETY

Oral LD50, rat, acute*:  ≥ 2000 mg/kg
Dermal LD50, rat, acute*: >2000 mg/kg
* These values refer to the active ingredient. Toxicity has to be determined for each formulation as well. Formulations are usually significantly less toxic than the active ingredients.

MRL (maximum residue limit): Not applicable: not approved for livestock
Withholding periods for meat, milk, eggs: Not applicable: not approved for livestock

General safety information for antiparasitics is available in specific articles in this site (click to visit):

<WARNING

Never use agricultural or hygiene products with this or any other active ingredient on livestock or pets, even if there are veterinary products with this same active ingredient approved for use on animals. The formulations for agricultural or hygiene use are different and may be toxic for livestock or pets.

It is obvious that veterinary products are not intended for and should never be used on humans!!!


MARKETING & USAGE

Decade of introduction: 1990
Introduced by: MITSUI
Some original brands: VECTRAVETRA 3D (ex CEVA, for pets)
Patent: Expired (particular formulations may be still patent-protected)

Use on LIVESTOCK: No
Use on HORSES: NO
Use on
DOGS and CATS: Yes, scarcely

Main delivery forms:

Use in human medicine: No
Use in
public/domestic hygiene: Yes
Use in
agriculture: Yes
Generics available: 
Yes, a few


PARASITE RESISTANCE

On livestock: reported on houseflies for other neonicotinoids (imidacloprid, thiamethoxam), most probably cross-resistance with dinotefuran.
On pets: No 


SPECIFIC FEATURES

Dinotefuran is a neonicotinoid insecticide used on dogs and cats in spot-ons (=pipettes, squeeze-on) for flea control (VECTRA, VECTRA 3D) and in baits for off-animal use against houseflies and other nuisance flies in livestock operations (poultry houses, stables, piggeries, etc.).

It is not effective against ticks, mites or lice. For this reason it is also used in mixtures with other active ingredients that broaden the spectrum of activity.

The fly bait acts mainly as an oral insecticide for flies, i.e. it does not control bloodsucking flies or other insects.

Pharmacokinetics of dinotefuran

After topical administration to dogs and cats dinotefuran remains mostly on the animal's surface and is not absorbed. However a certain amount can be ingested through licking and grooming. In laboratory animals ingested dinotefuran was almost completely absorbed (>90%) quickly distributed throughout the whole body and also rapidly eliminated, mostly through urine in the form of unchanged dinotefuran.

Mechanism of action of dinotefuran

As all neonicotinoids dinotefuran is an agonists of the nicotinic acetylcholine receptors. It takes the place of the normal neurotransmitter acetylcholine in the receptors, which cannot be deactivated by acetylcholinesterase and remains irreversibly blocked. This leads to an over stimulation of the nerve cells, to paralysis and to death of the affected insect.

These receptors are found in the central and peripheral nervous system of mammals, but only in the central nervous systems of insects. Neonicotinoids bind much more strongly to insect receptors than to mammal receptors, which makes them relatively safe for domestic animals and humans.

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