EFFICACY AGAINST PARASITES
Efficacy against a specific parasite depends on the delivery form and on the dose administered.
Click here for general information on features and characteristics of PARASITICIDES.
Dosing recommendations for antiparasitics depend on national regulations. National regulatory authorities determine whether a product is approved for a given indication, i.e. use on a particular host at a specific dose and against a specific parasite. Check the labels of the products available in your country for specific information on approved indications.
The table below indicates some usual dosing recommendations for propoxur issued by manufacturers or documented in the scientific literature. They may not be approved in some countries.
Propoxur is a contact insecticide and acaricide without systemic effect that belongs to the chemical class of the carbamates. It is effective against several external parasites of pets (e.g. fleas, ticks, lice, mites) and livestock. It is not effective against internal parasites. Propoxur is still used moderately in dogs and cats, mainly in low-cost sprays, shampoos, soaps, etc. or in insecticide-impregnated collars. It is still used in larvicidal dressings for livestock in some countries (mainly Latin America), otherwise usage in livestock or horses is irrelvant.
Most delivery forms (sprays, shampoos, soaps, powders, etc.) do not allow a precise calculation of the dose rate in terms of mg/kg.
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Oral LD50, rat, acute*: 50 mg/kg
Dermal LD50, rat, acute*: >5000 mg/kg
* These values refer to the active ingredient. Toxicity has to be determined for each formulation as well. Formulations are usually significantly less toxic than the active ingredients.
MRL (maximum residue limit) established for either beef, mutton pork or chicken meat*:
- CODEX: No
- EU: No
- USA: No
- AUS: No
* This information is an indicator of the acceptance of an active ingredient by the most influential regulatory bodies for use on livestock. An MRL for meat may be established also for agricultural pesticides that are not approved for use on animals but are used on commodities fed to animals. It may be also established in the form of an IMPORT TOLERANCE for active ingredients not approved in a particular country but approved for imported animal commodities.
Withholding periods for meat, milk, eggs, etc. depend on delivery form, dose and national regulations. Check the product label in your country.
Learn more about propoxur safety (poisoning, intoxication, overdose, antidote, symptoms, etc.).
General safety information for antiparasitics is available in specific articles in this site (click to visit):
- General safety of antiparasitics for domestic animals
- General safety of antiparasitics for humans
- General safety of antiparasitics for the environment
Never use products for livestock on dogs and cats, unless they are explicitly approved for both livestock and pets. Pets may not tolerate livestock formulations.
Never use agricultural or hygiene products with this or any other active ingredient on livestock or pets, even if there are veterinary products with this same active ingredient approved for use on animals. The formulations for agricultural or hygiene use are different and may be toxic for livestock or pets.
It is obvious that veterinary products are not intended for and should never be used on humans!!!
MARKETING & USAGE
Decade of introduction: 1960
Introduced by: BAYER
Some original brands: BOLFO, BAYGON
Patent: Expired (particular formulations may be still patent-protected)
Use in LIVESTOCK: Yes, very scarce
Use in HORSES: NO
Use in DOGS and CATS: Yes, quite frequent
Main delivery forms:
Use in human medicine: No
Use in public/domestic hygiene: Yes
Use in agriculture: Yes
Generics available: Yes
Propoxur is a broad-spectrum carbamate insecticide abundantly used in dogs and cats in the 1970's to 1990's before the introduction of modern highly effective flea and tick spot-ons.
It is still used a lot in public and domestic hygiene products.
It is quite effective against all kinds of insects and ticks. However, resistance of dog and cat fleas (Ctenocephalides spp) and mosquitoes to carbamates is already quite frequent and products with propoxur may not achieve the expected efficacy.
Pharmacokinetics of propoxur
Topically administered propoxur remains mostly on the hair-coat of the treated animals and is very poorly absorbed through the skin. Treated animals can ingest propoxur through licking or grooming. Absorption of ingested propoxur to blood is very fast. It is also quickly excreted through urine. Rats eliminated up to 85% of the administered dose within 16 hours.
Mechanism of action of propoxur
As all carbamate insecticides propoxur acts on the nervous system of the parasites (but also of mammals, birds, fish and many organisms!) as inhibitor of acetylcholinesterase (also known as AchE), an enzyme that hydrolyzes acetylcholine (Ach). Ach is a molecule involved in the transmission of nervous signals from nerves to muscles (so-called neuromuscular junctions) and between neurons in the brain (so-called cholinergic brain synapses).
AchE's role is to terminate the transmission of nervous signals where Ach is the neurotransmitter (there are several other neurotrasmitters). By inhibiting the activity of AchE, carbamates prevent the termination of those nervous signals, i.e. the neurons remain in constant activity and excitation, massively disturbing the normal movements of the parasites. The bottom line for the parasites is that they are paralyzed and die more or less quickly. Carbamates bind reversibly to AchE, in contrast with organophosphates, another chemical class of parasiticides, which bind irreversibly to AchE.
Click here to view the list of all technical summaries of antiparasitic active ingredients in this site.