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Besides antiparasitic drugs that control only external parasites (fleas, ticks, mites, etc.) and those that control only internal parasites (mainly parasitic worms), a few antiparasitic drugs control both external parasites (mainly fleas, very few ones also ticks) and internal parasites (mainly heartworms and roundworms) of dogs and cats.

All these products have in common that they are highly effective (usually >90%) against the parasites and offer at least about 1 month protection against re-infestation. Most of these products need a prescription and are sold only in pharmacies or veterinary clinics. They have been developed by large pharmaceutical or agrochemical companies.


This section of parasitipedia.net lists the most popular brands of these type of products.

You can select the corresponding article in this site from the corresponding menu or in the tables below:


Flea (+tick) + worm spot-ons

Brand Hosts Indications Countr. Active ingredients
Advantage Multi Do, Ca Fl, Mi, HwRw Int. Imidacloprid + moxidectin
Advocate Do, Ca Fl, Mi, Hw, Rw Int. Imidacloprid + moxidectin
Broadline Ca Fl, Ti, Hw, Rw, Tw Int. Fipronil + methopreneeprinomectin + praziquantel
Endectrid Do, Ca Fl, Mi, HwRw UK Imidacloprid + moxidectin
Prinovox Cats Ca Fl, Mi, HwRw UK Imidacloprid + moxidectin
Prinovox Dogs Do Fl, Mi, HwRw UK Imidacloprid + moxidectin
Revolution Do, Ca Fl, Mi, Hw, Rw Int. Selamectin
Stronghold Do, Ca Fl, Mi, Hw, Rw Int. Selamectin
Stronghold Plus Ca Fl, Ti, Hw, Rw, Li, Mi UK Selamectin + sarolaner

Flea (+tick) + worm tablets

Brand Hosts Indications Countr. Active ingredients
Nexgard Spectra Do Fl, Ti, HwRw Int. Afoxolaner + milbemycin oxime
Panoramis Do Fl, Hw, Rw Int. Milbemycin oxime + spinosad
Program Plus Do Fl, Hw, Rw Int. Milbemycin oxime + lufenuron
Sentinel Do Fl, Hw, Rw Int. Milbemycin oxime + lufenuron
Sentinel Spectrum Do Fl, Hw, Rw, Tw Int. Milbemycin oxime + lufenuron + praziquantel
Trifexis Do Fl, Hw, Rw Int. Milbemycin oxime + spinosad

Legend: Fl=fleas; Ti=ticks; Mi=mites; Hw=heartworms; Rw=roundworms; Tw=tapeworms

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