Brand: AGRIMECTIN ® injection
CATTLE, SWINE (also reindeer & bison)
PARASITES CONTROLLED* (spectrum of activity)
* Country-specific differences may apply: read the product label
- Gastrointestinal roundworms (adults and L4 larvae): Ostertagia ostertagi (incl. inhibited larvae), Ostertagia lyrata, Haemonchus placei, Trichostrongylus axei, Trichostrongylus colubriformis, Cooperia oncophora, Cooperia punctata, Cooperia pectinata, Oesophagostomum radiatum, Bunostomum phlebotomum, Nematodirus helvetianus (adults only), Nematodirus spathiger (adults only).
- Lungworms (adults and fourth-stage larvae): Dictyocaulus viviparus.
- Cattle grubs (warbles, parasitic stages): Hypoderma bovis, Hypoderma lineatum.
- Sucking lice: Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus.
- Mites (scabies): Psoroptes ovis (syn. P. communis var. bovis), Sarcoptes scabiei var. bovis
- Residual effect: Dictyocaulus viviparus up to 28 days; Ostertagia ostertagi up to 21 days; Oesophagostomum radiatum up to 21 days; Cooperia spp up to 14 days; Trichostrongylus axei up to 14 days; Haemonchus placei up to 14 days.
- Gastrointestinal roundworms: Ascaris suum (adults and L4 larvae), Red stomach worm Hyostrongylus rubidus (adults and L4 larvae), Nodular worm Oesophagostomum spp. (adults and L4 larvae), Threadworm Strongyloides ransomi (adults and somatic larvae).
- Lungworms: Metastrongylus spp (adults).
- Lice: Haematopinus suis.
- Mange mites: Sarcoptes scabiei var. suis.
*Can be slightly different in some countries: read the product label!
- Cattle: 2 mg/10 kg = 200 mcg /10 kg bw, equivalent to 1 ml/50 kg
- Swine: 3 mg/10 kg bw = 300 mcg/kg bw, equivalent to 1 ml/33 kg
- LD50 (acute oral) in rats: ~2500 mg/kg (estimate according to WHO 2009 recommendation)
- LD50 (acute dermal) in rats: ~660 mg/kg (for the a.i. ivermectin)
- Estimated hazard class according to the WHO: not applicable for veterinary medicines
Suspected poisoning? Read the article on ivermectin safety in this site.
Withholding period for meat (country-specific differences may apply: read the product label)
- Cattle: USA: 35 days
- Swine: USA: 18 days
Not approved for use on dairy animals producing milk for human consumption.
Non-lactating dairy cattle: treat at least 2 months prior to calving.
WARNING !!!: Never use on humans, dogs and cats
Risk of resistance? YES, in gastrointestinal roundworms in sheep (very high), goats (very high) and cattle (high) particularly in:
- Sheep & goats: Haemonchus spp, Ostertagia spp /Teladorsagia spp, Trichostrongylus spp, Nematodirus spp, Chabertia ovina
- Cattle: Cooperia spp, Haemonchus spp, Oesophagostomum spp, Ostertagia spp, Trichuris spp
Resistance of gastrointestinal roundworms to ivermectin in sheep, goats and cattle has been reported almost worldwide, including the USA, UK, Australia and New Zealand. Based on the very abundant and frequent use of ivermectin and other macrocyclic lactones (with cross-resistance to ivermectin) in livestock it must be assumed that resistance of these roundworms to this chemical class will continue spreading and strengthening in the future.
This means that if this product does not achieve the expected efficacy against the mentioned parasites, it may be due to resistance and not to incorrect use, which is usually the most frequent cause of product failure.
- Benzimidazoles, e.g. albendazole, febantel, fenbendazole, oxfendazole, etc. Similar or even worse resistance problems than macrocyclic lactones
- Imidazothiazoles, mainly levamisole. etc. Similar or even worse resistance problems than macrocyclic lactones
- Monepantel, only for sheep & goats in some countries (e.g. EU, Australia, New Zealand)
- Nitroxinil (limited spectrum of activity)
- Tetrahydropyrimidines, e.g. morantel, pyrantel (limited spectrum of activity)
- Salicylanilides, e.g. closantel (limited spectrum of activity)
These alternative products may not be available in all countries, or may not be available as injectables.
Are the active ingredients of this product ORIGINAL* or GENERICS**?
*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.
COUNTRIES where this product is marketed (maybe under another TM): USA
GENERIC BRANDS available? YES, by the hundreds in the whole world. Ivermectin 1% injectable is probably the veterinary product with more generic brands worldwide.
Click here to learn more about GENERIC vs. ORIGINAL drugs.
For an overview on the most used antiparasitic injectable brands for livestock click here.
AGRI-MECTIN injection is one of the numberless generic brands of the ivermectin 1% injectable formulation, in this case from AGRILABS, marketed by several distributors.
Whereas this type of ivermectin 1% injectables are approved for use on cattle worldwide, approval for use on sheep, swine & goats depends on the country. These differences are most likely due to marketing strategies of the different companies (e.g. market segmentation, local product portfolio, etc.) and not to regulatory hurdles.
Unfortunately, withholding periods for meat of the ivermectin 1% injectable vary considerably in different countries. This illustrates the fact that national regulatory authorities often draw different conclusions from exactly the same scientific evidence. This has been always so and there are no indications that things will improve in the near future.
Being one of the best antiparasitics ever developed, ivermectin does not control all parasites of livestock. Unfortunately advertising and even the label of some generic formulations in less developed countries often include unsubstantiated claims. To help preventing confusion and misuse it is useful to know that whatever ivermectin 1% injectable used at the recommended dose DOES NOT CONTROL:
- Ticks (e.g. Amblyomma spp, Rhipicephalus spp, Dermacentor spp, Haemaphysalis spp, Hyalomma spp, Ixodes spp, etc.)
- Flies (e.g. horn flies, houseflies, stable flies, black flies, horse flies, etc.)
- Fleas (e.g. Ctenocephalides spp)
- Blowfly strike of sheep
- Tapeworms (e.g. Moniezia spp spp)
- Flukes (e.g. liver fluke Fasciola hepatica)
This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics.
Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.
In case of doubt contact the manufacturer or a veterinary professional