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Brand: MAXIMUS Long Acting Injection for Sheep

Company: ANCARE


FORMULATION: «injectable» to be administered subcutaneoulsy at the base of the ear or high in the neck behind the ear.

ACTIVE INGREDIENT(S): moxidectin 20 mg/mL (=2.0%)

CHEMICAL CLASS of the active ingredient(s): macrocyclic lactone


INDICATIONS: SHEEP 


PARASITES CONTROLLED* (spectrum of activity)

* Country-specific differences may apply: read the product label.


RECOMMENDED DOSE*

  • Sheep: 1 mg/kg bw, equivalent to 1 ml/20 kg bw

* Can be slightly different in some countries: read the product label!


SAFETY

  • LD50 (acute oral) in rats: 42 mg/kg (for the a.i., source MSDS)
  • LD50 (acute dermal) in rats: >2000 mg/kg (for the a.i., source MSDS)
  • Estimated hazard class according to the WHO: not applicable for veterinary medicines

Suspected poisoning? Read the article on moxidectin safety in this site.

Withholding periods (=withdrawal times) in days for meat & milk (country-specific differences may apply: read the product label)

  • Meat: Australia 91 (ESI 133)
  • Milk: Australia: Not approved. Do not use in female sheep which are producing or may produce in the future milk or milk products for human consumption.

WARNING !!!: Never use on humans, dogs or cats


RESISTANCE PREVENTION

Risk of resistance? YES, in gastrointestinal roundworms in sheep (very high), goats (very high) particularly in Haemonchus sppOstertagia spp /Teladorsagia spp, Trichostrongylus spp, Nematodirus spp, Chabertia ovina

Resistance of gastrointestinal roundworms to macrocyclic lactones in sheep, goats and cattle has been reported in numerous countries. Most cases have been reported for ivermectin, and moxidectin often works well against ivermectin-resistant worms initially. But if moxidectin use continues gastrointestinal roundworms will become resistant to it rather quickly. Based on the very abundant and frequent use of ivermectin and other macrocyclic lactones in livestock (with more-or-less cross-resistance to ivermectin) it must be assumed that resistance of gastrointestinal roundworms to this chemical class will continue spreading and strengthening in the future.

Alternative chemical classes/active ingredients to prevent resistance of gastrointestinal roundworms through product rotation:

These alternative products may not be available in all countries, or may not be available as injectables.

Learn more about resistance and how it develops.


MARKETING

Are the active ingredients of this product ORIGINAL* or GENERICS**?

  • GENERICS

*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.

COUNTRIES where this brand/product is marketed: AUSTRALIA
GENERIC BRANDS available? YES in Australia, not in many other countries. It happens that many Animal Health companies without an own macrocyclic lactone (ML) for livestock prefer generic ivermectin instead of moxidectin or other macrocyclic lactones. A simple reason is that ivermectin was the first ML that lost patent protection and became available in the generics market. Another one is that the offer of generic ivermectin is much higher and thus prices lower than for moxidectin or other MLs (e.g. doramectin, eprinomectin, etc.). Although moxidectin may have some advantages over ivermectin in particular markets (e.g. sheep scab control), ivermectin is often good enough for most indications.

Click here to learn more about GENERIC vs. ORIGINAL drugs.

For an overview on the most used antiparasitic injectable brands for livestock click here.


COMMENTS

MAXIMUS Long ActinG Injection for sheep is one of several Australian brands containing 2% moxidectin, in this case marketed by ANCARE.

The main benefit over the 1% moxidectin injectable (e.g. CYDECTIN, available for use on sheep in numerous countries) is the significantly longer protection against certain gastrointestinal roundworms. The main disadvantage is the very long withholding period of 3 months.

Moxidectin is generally considered as more potent than ivermectin against gastrointestinal nematodes of livestock, particularly in sheep and goats, and against a few other livestock pests (e.g. sheep scab, cattle ticks, etc.). It is also less toxic than ivermectin, which makes it possible to use it at higher rates, particularly in long-acting formulations.

There are other formulations for topical (pour-on) and oral (drench) administration, mainly for cattle and/or sheep. So far there are no moxidectin products for use on swine.

Being an excellent antiparasitic, comparable to ivermectin, moxidectin does not control all parasites of livestock. Unfortunately advertising and even the label of some generic formulations in less developed countries often include unsubstantiated claims. To help preventing confusion and misuse it is useful to know that whatever moxidectin 2% injectable used at the recommended dose DOES NOT CONTROL:


DISCLAIMER

This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics. 

Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.

In case of doubt contact the manufacturer or a veterinary professional.

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