Brand: CLIK ® Spray-on / Pour-on for Sheep

Company: ELANCO (NOVARTIS)


FORMULATION: «spray-on/pour-on» for topical administration.

ACTIVE INGREDIENT(S)dicyclanil 50 g/L (= 5%)

CHEMICAL CLASS of the active ingredient(s): insect growth regulator (= IGR, cyanopyrimidine)


INDICATIONS: SHEEP

PARASITES CONTROLLED* (spectrum of activity)

* Country-specific differences may apply: read the product label.


RECOMMENDED DOSE*

* Can be slightly different in some countries: read the product label!

  • Highest dose: approx. 0.6 - 2 ml (30 - 100 mg dicyclanil) per kg bodyweight.

Use recommendations (Australia):

Sheep weight (kg) Dose rate (mL) Vol.per treatment band (mL) Number of bands
For the prevention of body strike
10 - 20 14 7 2
21 - 30 16 8 2
31 - 50 20 10 2
>50 24 12 2
For the prevention of body and crutch strike
10 - 20 21 7 3
21 - 30 24 8 3
31 - 50 30 10 3
>50 36 12 3
For the prevention of fly strike after mulesing
Up to 30 8 4 2
31 - 50 10 5 2

Read the product label for further details on dosing and administration.


SAFETY

  • LD50 (acute oral) in rats: >5000 mg/kg (source: MSDS)
  • LD50 (acute dermal) in rats: >5000 mg/kg (source: MSDS)
  • Estimated hazard class according to the WHO classification of pesticides: not listed

Suspected poisoning? Read the article on dicyclanil safety in this site.

Withholding periods (=withdrawal times) for meat, milk & shearing (country-specific differences may apply: read the product label)

  • Meat: UK 40 days; Australia 28 days (ESI 60 to 120 days depending on wool length at treatment); New Zealand 35 days (Merino sheep 56 days).
  • Milk for human consumption: Not approved in UK and Australia. New Zealand: discard milk for 35 days following treatment.
  • Shearing: UK & Australia 3 months; New Zealand 2 months.

You may be interested in the following articles in this site dealing with the general safety of veterinary products:


RESISTANCE PREVENTION

Risk of resistance? YES but rather low, mainly in Australia.

It has been shown that houseflies & blowflies resistant to cyromazine (another IGR vastly used for blowfly strike prevention) have some degree of cross-resistance to dicyclanil. However, resistance of blowflies to cyromazine is still quite unusual. It has been reported for Lucilia cuprina in a few locations in Australia, but so far not in the UK, other EU countries, South Africa or New Zealand. In those cases of cyromazine field resistance reported in Australia resistance factors were very low (about 2.3 for cyromazine, 1.3x for dicyclanil) and the concerned products were still providing protection according to registered label claims.

Alternative chemical classes/active ingredients to prevent resistance of blowflies to dicyclanil product rotation:

These alternative products may not be available in all countries, or may not be available as spray-ons/pour-ons.

Learn more about resistance and how it develops.


MARKETING

Are the active ingredients of this product ORIGINAL* or GENERICS**?

  • GENERICS

*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.

COUNTRIES where this brand/product is marketed: Australia, UK and other EU countries, New Zealand.
GENERIC BRANDS available? Although several generic brands have been registered in Australia (e.g. from JUROX or ZOETIS) they are not yet listed in the websites of these companies.

Click here to learn more about GENERIC vs. ORIGINAL drugs.

For an overview on the most used antiparasitic pour-on brands click here.


COMMENTS

CLIK Spray-on/Pour-on for sheep is the first and original product containing dicyclanil introduced by NOVARTIS (now ELANCO) in the late 1990s. It was the first product that ensured season-long protection of sheep against blowfly strike, which was a considerable progress in those years. It still remains the "Rolls Royce" of blowfly strike prevention.

Dicyclanil is an insect development inhibitor with a very specific efficacy againts dipteran larvae. So far it is exclusively used in sheep, and not at all in other livestock, pets or agriculture.

An interesting feature of CLIK is its formulation. It is a suspo-emulsion in water. Since dicyclanil is very poorly soluble in water, it is diluted in small oil droplets, which on their turn are emulsified in water. The practical consequence is that CLIK consist mainly of water instead of organic solvents as most other parasiticides. However, once administerd to sheep, the oily droplets carrying the active ingredient attach to the wool lipids where dicyclanil is dissolve to remain their for weeks.

In some countries NOVARTIS introduced CLIKZIN, a light version of CLIK, i.e. a less concentrated formulation useful when shorter protection periods are required. Also in some countries CLIK PLUS is marketed, a combination of dicyclanil with diflubenzuron that controls and prevents sheep body lice as well.

For those visitors that have reached these depths of parasitipedia.net here's a personal message. I was very heavily involved in the discovery and development of CLiK in the 1990s during my years in NOVARTIS AH. Click here if you want to know more about the discovery and development of CLiK.


DISCLAIMER

This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics. 

Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.

In case of doubt contact the manufacturer or a veterinary professional.

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