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Brand: CLIKZIN ® Spray-on / Pour-on for Sheep

Company: NOVARTIS AH


FORMULATION: «spray-on/pour-on» for topical administration.

ACTIVE INGREDIENT(S)dicyclanil 12.5 g/L (= 1.25%)

CHEMICAL CLASS of the active ingredient(s): insect growth regulator (= IGR, cyanopyrimidine)


INDICATIONS: SHEEP

PARASITES CONTROLLED* (spectrum of activity)

* Country-specific differences may apply: read the product label.

  • Prevention against blowfly strike on sheep, either off-shears or with any length wool, against fly strike (Lucilia spp) for up to 11 weeks (Australia) or 8 weeks (UK).
  • Marking wounds on sheep against fly strike (Lucilia spp) during the wound healing process.

RECOMMENDED DOSE*

*Can be slightly different in some countries: read the product label!

Use recommendation Australia*:

Highest dose: approx. 0.35-1ml (3.75-12.5 mg dicyclanil) per kg bodyweight

Sheep weight (kg) Dose rate (mL) Vol.per treatment band (mL) Number of bands
For the prevention of body strike & crutch strike
10 - 20 10 10 1
21 - 30 12 12 1
31 - 50 15 7.5 2
>50 18 9 2

Use recommendations UK*:

Highest dose: approx. 0.7-2ml (7.5-25 mg dicyclanil) per kg bodyweight

Sheep weight (kg) Dose rate (mL) Vol.per treatment band (mL) Number of bands
For the prevention of body strike & crutch strike
10 - 20 20 5 4
21 - 30 24 6 4
31 - 50 30 7.5 4
>50 38 9 4

To ensure an accurate spread of CLIKZIN apply the total required dose one quarter at a time:

  1. ¼ of dose from mid-shoulders to middle of back
  2. ¼ of dose from middle of back to top of tail
  3. ¼ of dose to one side of animal’s tail and crutch
  4. ¼ of dose to other side of animal’s tail and crutch

*Read the product label for further details on dosing and administration.


SAFETY

  • LD50 (acute oral) in rats: >5000 mg/kg (source: MSDS)
  • LD50 (acute dermal) in rats: >5000 mg/kg (source: MSDS)
  • Estimated hazard class according to the WHO: not listed

Suspected poisoning? Read the article on dicyclanil safety in this site.

Withholding periods (=withdrawal times) for meat, milk & shearing (country-specific differences may apply: read the product label)

  • Meat: UK, Australia & New zealand 7 days (ESI in Australia 21 days).
  • Milk for human consumption: Not approved in UK and Australia; New Zealand: discard milk for 35 days following treatment
  • Shearing: UK & Australia 1 month; New Zealand 2 months.

You may be interested in the following articles in this site dealing with the general safety of veterinary products:


RESISTANCE PREVENTION

Risk of resistance? YES but rather low, mainly in Australia.

It has been shown that houseflies & blowflies resistant to cyromazine (another IGR vastly used for blowfly strike prevention) have some degree of cross-resistance to dicyclanil. However, resistance of blowflies to cyromazine is still quite unusual. It has been reported for Lucilia cuprina in a few locations in Australia, but so far not in the UK, other EU countries, South Africa or New Zealand. In those cases of cyromazine field resistance reported in Australia resistance factors were very low (about 2.3 for cyromazine, 1.3x for dicyclanil) and the concerned products were still providing protection according to registered label claims.

Alternative chemical classes/active ingredients to prevent resistance of blowflies to dicyclanil product rotation:

These alternative products may not be available in all countries, or may not be available as spray-ons/pour-ons.

Learn more about resistance and how it develops.


MARKETING

Are the active ingredients of this product ORIGINAL* or GENERICS**?

  • GENERICS

*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.

COUNTRIES where this brand/product is marketed: Australia, UK, New Zealand
GENERIC BRANDS available? YES, (e.g. in Australia & New Zealand) but so far not in the EU.

Click here to learn more about GENERIC vs. ORIGINAL drugs.

For an overview on the most used antiparasitic pour-on brands click here.


COMMENTS

CLIKZIN Spray-on/Pour-on for sheep is a light version of CLIK introduced by NOVARTIS (now ELANCO) for markets were a shorter protection (≤11 weeks in Australia; ≤8 weeks in the UK) than the one achieved by CLIK(up to 24 weeks) is required. 

CLIK was the first and original product containing dicyclanil introduced by NOVARTIS (now ELANCO) in the late 1990s. It was the first product that ensured season-long protection of sheep against blowfly strike, which was a considerable progress in those years.

Dicyclanil is an insect development inhibitor with a very specific efficacy againts dipteran larvae. So far it is exclusively used in sheep, and not at all in other livestock, pets or agriculture.

In some countries NOVARTIS (now ELANCO) markets also CLIK PLUS, a combination of dicyclanil with diflubenzuron that controls and prevents sheep body lice as well.


DISCLAIMER

This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics. 

Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.

In case of doubt contact the manufacturer or a veterinary professional.

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