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Brand: CYDECTIN ® TRICLAMOX Pour-on Solution

Company: ZOETIS


FORMULATION: «pour-on» for topical administration. To be administered directly to the hair and skin along the midline of the back of the animal from the withers to the tail head. Apply to clean healthy skin.

ACTIVE INGREDIENT(S):

CHEMICAL CLASS of the active ingredient(s):


INDICATIONS: CATTLE

PARASITES CONTROLLED* (spectrum of activity)

* Country-specific differences may apply: read the product label.


RECOMMENDED DOSE*

* Can be slightly different in some countries: read the product label!


SAFETY

  • LD50 (acute oral) in rats:
    • moxidectin: a.i. 106 mg/kg
    • triclabendazole: a.i. > 5000 mg/kg
  • LD50 (acute dermal) in rats:
    • moxidectin: a.i. >2000 mg/kg
    • triclabendazole: a.i. > 4000 mg/kg
  • Estimated hazard class according to the WHO: not applicable for veterinary medicines

Suspected poisoning? Read the articles on moxidectin safety and triclabendazole safety in this site.

Withholding periods (=withdrawal times) in days for meat & milk (country-specific differences may apply: read the product label)

  • Meat: UK + EU countries 143 days
  • Milk for human consumption: UK + EU countries do not use in cattle of any age intended to produce milk for human consumption.

WARNING !!!: Never use on humans, dogs or cats.

You may be interested in the following articles in this site dealing with the general safety of veterinary products:


RESISTANCE PREVENTION

Risk of resistance?

Gastrointestinal roundworms to macrocyclic lactones: YES, reported in cattle in numerous countries particularly in the following worm species: Cooperia spp and Ostertagia spp.

Resistance of gastrointestinal roundworms to macrocyclic lactones in sheep, goats and cattle has been reported in numerous countries. Most cases have been reported for ivermectin, and moxidectin often works well against ivermectin-resistant worms initially. But if moxidectin use continues gastrointestinal roundworms will become resistant to it rather quickly. Based on the very abundant and frequent use of ivermectin and other macrocyclic lactones in livestock (with more-or-less cross-resistance to ivermectin) it must be assumed that resistance of gastrointestinal roundworms to this chemical class will continue spreading and strengthening in the future.

Alternative chemical classes/active ingredients to prevent resistance of gastrointestinal roundworms through product rotation:

These alternative products may not be available in all countries, or may not be available as pour-ons.

Liver flukes to triclabendazole: YES. Resistance of liver flukes to triclabendazole (and albendazole) in sheep was already discovered in the mid 1990's in Australia. Since then it has been reported in several other countries (e.g. New Zealand, UK, Ireland, Spain, Argentina), also in cattle (e.g. Australia, The Netherlands, Argentina). However, the incidence so far is not that serious as for roundworm resistance to benzimidazoles and other nematicides. Nevertheless, in certain regions products with triclabendazole may not protect livestock adequately against liver flukes.

Alternative chemical classes/active ingredients to prevent resistance of liver flukes through product rotation:

These alternative products may not be available in all countries, may not be available as pour-ons, or may not have the same spectrum of efficacy as CYDECTIN TRICLAMOX.

This means that if this product does not achieve the expected efficacy against the mentioned parasites, it may be due to resistance and not to incorrect use, which is usually the most frequent cause of product failure.

Learn more about resistance and how it develops.


MARKETING

Are the active ingredients of this product ORIGINAL* or GENERICS**?

*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.

COUNTRIES where this brand/product is marketed: UK + other EU countries.
GENERIC BRANDS available? Not many in most countries, in this particular composition and as a pour-on. Several comparable combinations of triclabendazole with other macrocyclic lactones are more frequent, mainly as drenches.

Click here to learn more about GENERIC vs. ORIGINAL drugs.

For an overview on the most used antiparasitic pour-on brands click here.


COMMENTS

CYDECTIN TRICLAMOX Pour-on for cattle from ZOETIS combines the broad spectrum nematicidal and ectoparasiticidal efficacy of moxidectin with the flukicidal efficacy of triclabendazole.

Moxidectin is a broad-spectrum macrocyclic lactone introduced in the 1990s (by AMERICAN CYANAMID → FORT DODGE → ZOETIS). It is generally considered as more potent than ivermectin against gastrointestinal roundworms of livestock, particularly in sheep and goats, and against a few other livestock pests (e.g. sheep scab, cattle ticks, etc.). It is also less toxic than ivermectin, which makes it possible to use it at higher rates, particularly in long-acting formulations. Moxidectin has no efficacy whatsoever on liver flukes. It is moderately used in livestock and pets, but not in agriculture.

Triclabendazole is a veteran flukicide introduced in the late 1970s (by CIBA-GEIGY → NOVARTIS → ELANCO). It is abundantly used in livestock, but not in pets. it is also used in human medicines, but not in agriculture. It was and remains the only flukicide effective against adults as well as all immature stages of liver flukes, which are the most damaging ones due to their destructive migration through the liver tissues. Triclabendazole has no efficacy whatsoever on roundworms or any external parasites of cattle.

The combination of moxidectin and triclabendazole makes sense because it extends the spectrum of activity of both active ingredients.

It is useful to know that pour-on administration of parasiticides has some disadvantages when compared with injectables and drenches. In several scientific studies it has been shown that ivermectin administered as a pour-on is not "automatically" absorbed through the skin. Licking (self licking or licking of other treated animals) may account for >50% of the total intake, compared with only about 10% absorbed directly through the skin. This is the reason why a dose of 500 mcg/kg bw is needed after pour-on treatment, compared with only 200 mcg/kg bw after injection. And it has been also shown that intake of topically administered active ingredient in some cattle may be twice as high as in other ones, all treated at the same rate. The reason is that individual cattle show a different licking behavior. An important practical consequence is that the quantity that is finally ingested and is therefore available for the control of gastrointestinal worms depends on the licking behavior of the treated animals. "High lickers" can be overdosed, whereas "low lickers" can be underdosed. And chronic underdosing of animals in a herd may enhance development of resistance to ivermectin and other macrocyclic lactone in gastrointestinal roundworms.

To our knowledge similar studies have not been carried out with the CYDECTIN Pour-on, but it must be assumed that the licking-behavior of cattle affects intake of moxidectin in a comparable way. A similar effect of the licking behavior on the intake of active ingredient after pour-on administration has also been shown for fluazuron, a tick development inhibitor.

It is likely that licking and grooming also plays an important role in the intake of triclabendazole administered as a pour-on to cattle. The higher dose of 20 mg triclabendazole/kg bw after pour-on administration when compared with the usual dose of 12 mg/kg bw after oral administration (drench) reflects the fact that absorption of triclabendazole through the skin is also significantly lower than after oral administration.

Absorption through the skin is also negatively affected by the thickness of the skin and the hair coat, by dust and mud on the coat, by product lost on fences and yards, etc, factors that don't play a role after injection. The pour-on formulation should not be administered to wet animals, and rain shortly before (up to 6 hours) or after administration can cause product run-off and thus under-dosing. The pour-on shouldn't be administered by strong winds that may blow away part of the product and/or contaminate the workers.

For these reasons efficacy after pour-on administration is usually less reliable than after injection or oral administration (drench).


DISCLAIMER

This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics. 

Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.

In case of doubt contact the manufacturer or a veterinary professional.

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