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Brand: PARAMECTIN ® Injection

Company: JUROX


FORMULATION«injectable» to be administered subcutaneously preferably high on the neck behind the ear.

ACTIVE INGREDIENT(S): abamectin: 10 mg/mL =1%

CHEMICAL CLASS of the active ingredient(s): macrocyclic lactone


INDICATIONS: CATTLE


PARASITES CONTROLLED* (spectrum of activity)

* Country differences may appli: read the product label!


RECOMMENDED DOSE

  • 1 ml product/50 kg, equivalent to: abamectin 200 mcg/kg bw.

SAFETY

  • LD50 (acute oral) in rats: a.i. 10 mg/kg
  • LD50 (acute dermal) in rats: abamectin: a.i. 330 mg/kg
  • Estimated hazard class according to the WHO: not applicable for veterinary medicines

Suspected poisoning? Read the article on abamectin safety in this site.

Withholding periods (=withdrawal times) in days for meat & milk (country-specific differences may apply: read the product label)

  • Meat: Australia 30 days (ESI 42 days)
  • Milk for human consumption: Australia 30 days.

WARNING !!!: Never use on humans, dogs or cats


RESISTANCE PREVENTION

Risk of resistance of gastrointestinal roundworms to macrocyclic lactones (incl. abamectin): YES, reported in cattle in numerous countries particularly in the following worm species: Cooperia spp and Ostertagia spp.

Resistance of gastrointestinal roundworms to macrocyclic lactones (incl. abamectin) in sheep, goats and cattle has been reported almost worldwide, including the USA, UK, Australia and New Zealand. Based on the very abundant and frequent use of ivermectin and other macrocyclic lactones (with cross-resistance to ivermectin) in livestock it must be assumed that resistance of these roundworms to this chemical class will continue spreading and strengthening in the future.

Alternative chemical classes/active ingredients to prevent resistance of gastrointestinal roundworms through product rotation:

These alternative products may not be available in all countries, or may not be available as pour-ons.

This means that if this product does not achieve the expected efficacy against the mentioned parasites, it may be due to resistance and not to incorrect use, which is usually the most frequent cause of product failure.

Learn more about resistance and how it develops.


MARKETING

Are the active ingredients of this product ORIGINAL* or GENERICS**?

  • GENERICS

*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.

COUNTRIES where this brand/product is marketed: Australia
GENERIC BRANDS available? Yes abundant in Australia and New Zealand, not in the USA or Europe.

Click here to learn more about GENERIC vs. ORIGINAL drugs.

For an overview on the most used antiparasitic injectable brands for livestock click here.


COMMENTS

PARAMECTIN Injection for cattle from JUROX with generic abamectin is one of the numerous injectables with macrocyclic lactones for cattle.

Abamectin, a veteran endectocide introduced in the 1980s, is considered as the "cheap" macrocyclic lactone. It is less potent and more toxic than ivermectin and other macrocyclic lactones but is often "good enough", although usually with a slightly narrower spectrum of efficacy and shorter protection periods. Interestingly it is widely used on livestock in Australia and New Zealand but not at all in the EU, the USA and Canada. As for other macrocyclic lactones, abamectin has no efficacy whatsoever against tapeworms and flukes.


DISCLAIMER

This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics. 

Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.

In case of doubt contact the manufacturer or a veterinary professional.

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