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Brand: GENESIS ® Injection for Cattle & Sheep

Company: ANCARE


FORMULATION«injectable» to be administered subcutaneously preferably high on the neck behind the ear.

ACTIVE INGREDIENT(S): abamectin: 10 mg/mL =1%

CHEMICAL CLASS of the active ingredient(s): macrocyclic lactone


INDICATIONS: CATTLE & SHEEP


PARASITES CONTROLLED (spectrum of activity)

CATTLE

SHEEP


RECOMMENDED DOSE

  • Cattle: 1 ml product/50 kg, equivalent to: abamectin 200 mcg/kg bw.
  • Sheep: 0.1 ml product/5 kg, equivalent to: abamectin 200 mcg/kg bw.

SAFETY

  • LD50 (acute oral) in rats: a.i. 10 mg/kg
  • LD50 (acute dermal) in rats: abamectin: a.i. 330 mg/kg
  • Estimated hazard class according to the WHO: not applicable for veterinary medicines

Suspected poisoning? Read the article on abamectin safety in this site.

Withholding periods (=withdrawal times) in days for meat & milk (country-specific differences may apply: read the product label)

  • Meat: Cattle 42, Sheep 35; (ESI 42 days).
  • Milk for human consumption: Do not use in animals where milk or milk products may be used for human consumption.

WARNING !!!: Never use on humans, dogs or cats


RESISTANCE PREVENTION

Risk of resistance? YES, in gastrointestinal roundworms in sheep (very high) and cattle (high) particularly in:

Resistance of gastrointestinal roundworms to macrocyclic lactones (incl. abamectin) in sheep, goats and cattle has been reported almost worldwide, including the USA, UK, Australia and New Zealand. Based on the very abundant and frequent use of ivermectin and other macrocyclic lactones (with cross-resistance among thems) in livestock it must be assumed that resistance of these roundworms to this chemical class will continue spreading and strengthening in the future.

This means that if this product does not achieve the expected efficacy against the mentioned parasites, it may be due to resistance and not to incorrect use, which is usually the most frequent cause of product failure.

Alternative chemical classes/active ingredients to prevent resistance of gastroinitestinal roundworms through product rotation:

These alternative products may not be available in all countries, or may not be available as injectables.

Learn more about resistance and how it develops.


MARKETING

Are the active ingredients of this product ORIGINAL* or GENERICS**?

  • GENERICS

*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.

COUNTRIES where this brand/product is marketed: Australia
GENERIC BRANDS available? Yes abundant in Australia and New Zealand, not in the USA or Europe.

For an overview on the most used antiparasitic injectable brands for livestock click here.

Click here to learn more about GENERIC vs. ORIGINAL drugs.


COMMENTS

GENESIS Injection for Cattle & Sheep from ANCARE with generic abamectin is one of the numerous injectables with macrocyclic lactones for livestock.

Abamectin, a veteran endectocide introduced in the 1980s, is considered as the "cheap" macrocyclic lactone. It is less potent and more toxic than ivermectin and other macrocyclic lactones but is often "good enough", although usually with a slightly narrower spectrum of efficacy and shorter protection periods tha other macrocyclic lactones. Interestingly abamectin is widely used on livestock in Australia and New Zealand but not at all in the EU, the USA and Canada. As for other macrocyclic lactones, abamectin has no efficacy whatsoever against tapeworms and flukes.


DISCLAIMER

This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics. 

Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.

In case of doubt contact the manufacturer or a veterinary professional.

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