Brand: CYDECTIN ® LV SE Oral Drench with Selenium
- This brand contains also 1.0 mg/ml Selenium (as Sodium selenate), not an active ingredient.
PARASITES CONTROLLED (spectrum of activity)
- Gastrointestinal roundworms, adults & 4th stage larvae: Haemonchus contortus, Trichostrongylus spp, Trichostrongylus axei, Trichostrongylus colubriformis, Ostertagia (Teladorsagia) spp, Ostertagia circumcincta, Cooperia spp, Nematodirus spp, Nematodirus filicollis, Nematodirus spathiger, Strongyloides papillosus, Oesophagostomum columbianum, Chabertia ovina.
- Gastrointestinal roundworms, adults only: Trichostrongylus rugatus, Trichostrongylus vitrinus, Cooperia curticei, Nematodirus abnormalis, Nematodirus helvetianus, Ostertagia trifurcata, Oesophagostomum venulosum, Trichuris ovis.
- Lungworms, adults & 4th stage larvae: of Dictyocaulus filaria.
- Itch mites, Psorergates ovis.
- Residual effect: Prevents re-infection by Ostertagia spp and Haemonchus contortus for 14 days.
- Sheep: 1 ml product/10 kg bw (equivalent to 0.2 mg of moxidectin/kg)
- LD50 (acute oral) in rats:
- Moxidectin a.i. 106 mg/kg (according to MSDS)
- Praziquantel a.i. 2840 mg/kg (according to the MSDS)
- LD50 (acute dermal) in rabbit:
- Moxidectin a.i. >2000 mg/kg (according to MSDS)
- Praziquantel a.i. n.a.
Suspected poisoning? Read the article on moxidectin safety and/or in this site.
Withholding periods (=withdrawal times) for meat & milk (country-specific differences may apply: read the product label)
- Meat: Australia: 7 days (ESI = 7 days)
- Milk for human consumption: Australia: do not use in female sheep, which are producing or may in the future produce, milk or milk products for human consumption.
Risk of resistance? YES, resistance of gastrointestinal roundworms to macrocyclic lactones (incl. moxidectin) in ruminants is a very serious and increasing problem worldwide, particularly in sheep and goats. The most affected worm species are: Haemonchus spp, Ostertagia spp /Teladorsagia spp, Trichostrongylus spp, Nematodirus spp, Chabertia ovina.
Resistance of gastrointestinal roundworms to macrocyclic lactones in sheep, goats has been reported in numerous countries. Most cases have been reported for ivermectin, and moxidectin often works well initially against ivermectin-resistant worms. But if moxidectin use continues, gastrointestinal roundworms will become resistant to it rather quickly. Based on the very abundant and frequent use of ivermectin and other macrocyclic lactones in livestock (with more-or-less cross-resistance to ivermectin) it must be assumed that resistance of gastrointestinal roundworms to this chemical class will continue spreading and strengthening in the future.
- Benzimidazoles, e.g. albendazole, febantel, fenbendazole, oxfendazole, etc. Similar or even worse resistance problems than macrocyclic lactones.
- Levamisole. Resistance to levamisole has been reported in most countries, but is usually less strong and frequent than to macrocyclic lactones.
- Monepantel: available only for sheep & goats in some countries (e.g. Australia, UK & EU, New Zealand). First cases of resistance reported in New Zealand in 2013.
- Salicylanilides (e.g. closantel): effective only against certain gastrointestinal roundworms. Not available in some countries. Resistance to closantel has been reported in some countries.
- Tetrahydropyrimidines (e.g. morantel, pyrantel): effective only against certain gastrointestinal roundworms. Not available in some countries. Resistance to morantel has been reported in some countries.
- Nitroxinil: effective only against certain gastrointestinal roundworms (e.g. Bunostomum spp, Haemonchus spp, Oesophagostomum spp). Not available in some countries.
These alternative products may not be available in all countries, or may not be available as drenches, or may not be effective against all the concerned parasites.
It is highly recommended to periodically check the resistance status of each property performing appropriate tests (e.g. fecal egg counts) under supervision of a veterinary doctor. Such tests are now routinely available for most producers in developed countries.
Are the active ingredients of this product ORIGINAL* or GENERICS**?
*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.
COUNTRIES where this brand/product is marketed: Australia
GENERIC BRANDS available? YES, a few brands in some countries (e.g. Australia, New Zealand); rather few, if at all, in other countries (e.g. the EU, USA).
Click here to learn more about GENERIC vs. ORIGINAL drugs.
For an overview on the most used drench brands for livestock click here.
CYDECTIN LV SE Low Volume Oral Drench for sheep is a local brand from VIRBAC containing 0.2% moxidectin. In Australia VIRBAC markets also CYDECTIN ORAL and CYDECTIN ORAL SE, two 0.1% moxidectin drench formulations for sheep They require twice as much product to be administered to each animal. Otherwise both product have similar features.
Moxidectin is a veteran macrocyclic lactone introduced in the 1990s (by AMERICAN CYANAMID). It is generally considered as more potent than ivermectin against gastrointestinal nematodes of livestock, particularly in sheep and goats, and against a few other livestock pests (e.g. sheep scab, cattle ticks, etc.), although the drench formulation is not effective against most external parasites. It is also less toxic than ivermectin, which makes it possible to use it at higher rates, particularly in long-acting formulations. As all macrocyclic lactones, moxidectin used alone is ineffective against tapeworms and flukes, regardless of the delivery form.
In ruminants, reducing the amount of feed slows down the exit flow of the rumen and prolongs the time during which the active ingredient remains there and is absorbed. Consequently it is advisable to reduce the access of animals to feed (especially to fresh pasture, not to water) 24 hours before administration. For the same reason, it is better to keep the animals away from food for about 6 hours after drenching. However sick or weak animals should not be kept away from food and fasting animals should have access to water.
This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics.
Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.
In case of doubt contact the manufacturer or a veterinary professional.