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Brand: PARACIDE 62, Diazinon 62% w/v Concentrate for dip emulsion

Company: ANIMAX


FORMULATION: liquid concentrate for dipping sheep

ACTIVE INGREDIENT(S): Diazinon (= dimpylate): 62% = 62 g/L

CHEMICAL CLASS of the active ingredient(s): Organophosphate


INDICATIONS: SHEEP


PARASITES CONTROLLED (spectrum of activity)


RECOMMENDED DOSE

Sheep

Initial Dip Bath Preparation: Dilute at a rate of 1 litre Paracide 62 to 1500 litres of clean water, as shown below:

DIP BATH  VOLUME AMOUNT OF PRODUCT
600 400 ml
1200 800 ml
2400 1.6 litres
4800 3.2 litres

All replenishments: Dilute at the rate of 1 litre of Paracide 62 to 1000 litres of clean water. Replenish the bath after the passage of every 20 sheep through the bath according to the table below. If the drain back facilities are such that the bath volume is not depleted to the minimum volume indicated in the table after the passage of 20 sheep, it is necessary to replenish the bath with 50 ml of Paracide 62 together with the amount of water required to return the bath to the original volume, as shown below.

TOPPING UP

DIP BATH DROP VOLUME AMOUNT OF PRODUCT
50 50 ml
75 75 ml
100 100 ml
150 150 ml
200 200 ml
250 250 ml
 
MIXING
  • Prepare the bath freshly on the morning of dipping and stir thoroughly before beginning to dip in order to ensure uniform mixing. Add the dip concentrate to the full amount of clean water in the bath. Do not retain the dip wash for a second day's dipping.
DIPPING THE SHEEP
  • Keep the sheep moving in the bath, and plunge the head under two or three times. Never hold the head down or the sheep will be liable to swallow or inhale some of the wash. This dip must not be used in conjunction with any other dip and must be diluted in the recommended proportions.
Scab dipping
  • Sheep must be totally immersed in the dip bath and all parts of the sheep, except the head and ears, must remain immersed for not less than one minute.

Read the complete product label carefully and ensure thorough accomplishment of all the use instructions.


SAFETY

  • LD50 (acute oral) in rats: for the a.i. 1250 mg/kg
  • LD50 (acute dermal) in rats: for the a.i. >2150 mg/kg
    • Estimated hazard class according to the WHO: III, slightly hazardous.

Suspected poisoning? Read the article on diazinon = dimpylate safety in this site.

Withholding periods (=withdrawal times) in days for meat & milk (country-specific differences may apply: read the product label)

  • Cattle Meat: UK 70 days
  • Milk for human consumption: UK NOT TO BE USED on animals producing milk for human consumption.

WARNING !!!: Never use on humans, dogs or cats.

Diazinon and all organophosphates (e.g. coumaphosdichlorvos, phosmet, etc.) etc. are highly toxic to birds, fish and aquatic invertebrates.

Organophosphates dips are submitted to very strict operator safety precautions and dip wash disposal regulations. Read the product label carefully and ensure strict accomplishment of all safety instructions.


RESISTANCE PREVENTION

Risk of resistance? LOW.

There are reports on field resistance of Psoroptes ovis (sheep scab) against some organochlorines and organophosphates in Argentina, and against a few organophosphates and synthetic pyrethroids in the UK. However it does not seem to be a widespread problem and such products are still effective in many properties in these countries.

This means that if this product does not achieve the expected efficacy against the mentioned parasites, it is probably due to incorrect use rather than to a resistance problem. Incorrect use is usually the most frequent cause of product failure.

So far there are no reports on resistance of blowfly maggots, lice, keds or ticks to organophosphates in the UK or Europe. However, resistance of blowflies and lice to these and other chemicals has been reported elsewhere (e.g. Australia, New Zealand).

Alternative chemical classes/active ingredients to prevent resistance of external parasites through product rotation:

These alternative products may not be available in all countries, or may not be available for dipping, or may not be effective against all the concerned parasites.

Learn more about resistance and how it develops.


MARKETING

Are the active ingredients of this product ORIGINAL* or GENERICS**?

  • GENERIC

*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.

COUNTRIES where this brand/product is marketed: UK
GENERIC BRANDS available? YES, but rather few with diazinon in the UK. This brand contains itself generic diazinon and is marketed by ANIMEX in the UK.

Click here to learn more about GENERIC vs. ORIGINAL drugs.

For an overview on the most used antiparasitic spray, dip & dust BRANDS click here.


COMMENTS

Diazinon (also called dimpylate) is a veteran broad-spectrum organophosphate introduced in the 1950s by GEIGY (later CIBA-GEIGY → NOVARTIS) that has been very abundantly used worldwide in agriculture, hygiene and veterinary insecticides. In sheep, diazinon was particularly appreciated for the control and prevention of sheep scab mites, blowfly strike and lice. It has a high affinity for wool lipids, where it dissolves after administration and remains for a long period of time ensuring several weeks and even months protection against re-infestation.

Usage of diazinon products in sheep strongly declined after several countries imposed very strict safety precautions and dip wash disposal regulations (e.g. the UK & Australia) for all dips in the late 1990s. As a consequence use of these products became rather inconvenient and often also expensive. Soon after, NOVARTIS, the market leader for diazinon products for sheep, divested all its organophosphates for strategic reasons, including its diazinon sheep brands (NEOCIDOL, TOPCLIP). Nowadays, in many countries sprays and dips containing diazinon, other organophosphates and even synthetic pyrethroids have been vastly replaced by injectable macrocyclic lactones (e.g. doramectinivermectin, moxidectin, etc.) that have become affordable, are much more convenient than sprays & dips and as effective. Diazinon is still abundantly used worldwide in insecticide-impregnated ear-tags for fly control on cattle.

Used as recommended this product is highly effective against established infestations of mites (incl. sheep scab), blowfly strike, lice, and keds and ensuresl several weeks protection against re-infestation. Control of ticks is usually less effective. But to ensure efficacy it is crucial to dip the sheep correctly. To learn more about correct sheep dipping click here.

All organophosphates are veteran pesticides developed in the 1950s-1960s and are basically contact insecticides. This means that when the parasite comes in contact with it (e.g. during the blood meal, after landing on a treated host, etc), the active ingredient that impregnates the host's hair coat penetrates through the cuticle (i.e. the "skin" of insects and other arthropods) into its organism and disturbs essential biological processes in the parasite's body, in this case its nervous system.

After administration to livestock or other animals, organophosphates do not have a systemic mode of action, i.e. they are not transmitted to the parasite through the blood or the host. Topically administered organophosphates are very poorly absorbed through the skin of the hosts, and what is absorbed is quickly broken down and/or excreted. Consequently the concentration reached in the blood is too low to kill blood-sucking parasites.


DISCLAIMER

This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics. 

Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.

In case of doubt contact the manufacturer or a veterinary professional.

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