Brand: PARAGARD Allwormer Tablets for Dogs

Company: MERIAL


FORMULATION: «tablets» for oral administration; may be chewable, flavored, coated, etc.

ACTIVE INGREDIENT(S):

  • OXIBENDAZOLE:
    • for small dogs & puppies: 112.5 mg/tablet
    • for medium dogs: 225 mg/tablet
    • for large dogs: 450 mg/tablet
    • for cats & kittens: 112.5 mg/tablet
  • PRAZIQUANTEL: 25 mg
    • for small dogs & puppies: 25 mg/tablet
    • for medium dogs: 50 mg/tablet
    • for large dogs: 100 mg/tablet
    • for cats & kittens: 25 mg/tablet

CHEMICAL CLASS of the active ingredient(s):


INDICATIONS: DOGS & CATS

PARASITES CONTROLLED* (spectrum of activity):

DOGS

CATS


RECOMMENDED DOSE*:

  • Small dogs & puppies: 1 tablet for small dogs per 5 kg bw (equivalent to 22.5 mg/kg oxibendazole, 5 mg/kg praziquantel)
  • Medium dogs: 1 tablet for medium dogs per 10 kg bw (equivalent to 22.5 mg/kg oxibendazole, 5 mg/kg praziquantel)
  • Large dogs: 1 tablet for large dogs per 20 kg bw (equivalent to 22.5 mg/kg oxibendazole, 5 mg/kg praziquantel)
  • Cats & kittens: 1 tablet for cats & kittens per 5 kg bw (equivalent to 22.5 mg/kg oxibendazole, 5 mg/kg praziquantel)

* Can be slightly different in some countries: read the product label!


SAFETY

  • LD50 (acute oral) in rats: n.a. for the tablets. >10000 mg/kg for oxibendazole; 2840 mg/kg for praziquantel
  • Estimated Hazard Class according to the WHO: not applicable for veterinary medicines

Suspected poisoning? Read the article on praziquantel safety in this site.

You may be interested in the following articles in this site dealing with the general safety of veterinary products:


RESISTANCE PREVENTION

Risk of resistance development? VERY LOW

There are so far no reports on resistance of roundworms to oxibendazole or of tapeworms to praziquantel in dogs or cats.

Learn more about resistance and how it develops.


MARKETING

Are the active ingredients of this product ORIGINAL* or GENERICS**?

  • Oxibendazole: GENERIC (introduced in the 1970s)
  • Praziquantel: GENERIC (introduced in the 1970s)

*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.

COUNTRIES where this product is marketed: AUSTRALIA
GENERIC BRANDS available? YES, in some countries.

Click here to learn more about GENERIC vs. ORIGINAL drugs.


COMMENTS

Paragard Allwormer Tablets for Dogs or cats from MERIAL is a generic wormer effective against roundworms and tapeworms

Oxibendazole is a veteran benzimidazole introduced in the 1970s (by SMITH KLINE → PFIZER→ ZOETIS) that is rather scarcely used in pets, horses or ruminants. It is a broad-spectrum anthelmintic effective against roundworms in the gut and the lungs, but not against those in the skin. It has no efficacy whatsoever against external parasites.

Praziquantel is a veteran isoquinoline anthelmintic introduced in the 1970s (by BAYER). It is still the most effective and most vastly used parasiticide against tapeworms, but without any efficacy against roundworms, fleas or ticks. Praziquantel adds efficacy against tapeworms (e.g. Taenia spp) but has no efficacy whatsoever against roundworms, hookworms or whipworms. It is the anthelmintic most vastly used against tapeworms in pets. There are hundreds of antiparasitic brands for pets containing praziquantel.

Oxibendazole and praziquantel have no residual effect, i.e. they act against the worms during a few hours after administration but are quickly metabolized and excreted. For this reason treatment must often be repeated for certain indications.

For an overview and a list of the most popular pet wormers click here.


DISCLAIMER

This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics. 

Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.

In case of doubt contact the manufacturer or a veterinary professional.

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