Brand: POPANTEL ® Allwormer Tablets for DOGS
- PYRANTEL (as embonate salt):
- medium dogs: 143 mg/tablet
- large dogs: 572 mg/tablet
- OXANTEL (as embonate salt):
- medium dogs: 542 mg/tablet
- large dogs: 2168 mg/tablet
- medium dogs: 50 mg/tablet
- large dogs: 200 mg/tablet
CHEMICAL CLASS of the active ingredient(s):
PARASITES CONTROLLED* (spectrum of activity):
- Roundworms (Toxocara canis, Toxascaris leonina), hookworms (Ancylostoma caninum, Ancylostoma braziliense, Uncinaria stenocephala) & whipworms (Trichuris spp)
- Tapeworms (Dipylidium caninum, Taenia spp, Echinococcus granulosus)
- 1 tablet for medium dogs every 10 kg bw (equivalent to 14.3 mg/kg pyrantel embonate, 54.2 mg/kg oxantel embonate, 5.0 mg/kg praziquantel) Dosage should be rounded to the nearest ¼ tablet.
- 1 tablet for large dogs every 40 kg bw (equivalent to 14.3 mg/kg pyrantel embonate, 54.2 mg/kg oxantel embonate, 5.0 mg/kg praziquantel) Dosage should be rounded to the nearest ½ tablet.
* Can be slightly different in some countries: read the product label!
- LD50 (acute oral) in rats: n.a. for the tablets. >5000 mg/kg for pyrantel; 980 mg/kg for oxantel ; 2840 mg/kg for praziquantel
- Estimated Hazard Class according to the WHO: not applicable for veterinary medicines
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Risk of resistance development? YES, but rather low in Ancylostoma caninum.
There are reports on resistance of Ancylostoma spp to pyrantel in dogs and horses, but so far it does not seem to be widespread. There are no reports on resistance of dog tapeworms to praziquantel more than 40 years after their introduction.
Alternatives to prevent resistance through product rotation:
- Macrocyclic lactones (e.g. milbemycin oxime, selamectin)
- Imidazothiazoles (levamisole)
Are the active ingredients of this product ORIGINAL* or GENERICS**?
- Oxantel: GENERIC (introduced in the 1970s)
- Pyrantel: GENERIC (introduced in the 1960s)
- Praziquantel: GENERIC (introduced in the 1970s)
*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.
COUNTRIES where this product is marketed: Australia, New Zealand
GENERIC BRANDS available? YES, in some countries.
Click here to learn more about GENERIC vs. ORIGINAL drugs.
Pyrantel is a narrow-spectrum anthelmintic belonging to the chemical class of the tetrahydropyrimidines that was introduced in the 1960s (by PFIZER → ZOETIS). It is effective against roundworms and a few tapeworms (depending on the dose) in the gut, but not against those in other organs (e.g. the lungs, the skin, etc). It controls the most important dog worms such as the roundworms Toxocara canis and Toxascaris leonina, the hookworms Ancylostoma caninum and Uncinaria stenocephala. It is used a lot in pets and horses but rarely in livestock. There are dozens of products for pets with generic pyrantel.
Oxantel is a narrow-spectrum anthelmintic introduced in the 1970s (by PFIZER → ZOETIS) that belongs to the chemical class of the tetrahydropyrimidines. It is particularly effective against whipworms (Trichuris vulpis), but usually not sufficiently effective against other nematode species. Oxantel is scarcely used in pets, and not used at all in livestock or agriculture. Oxantel is not effective against tapeworms.
Praziquantel is a veteran isoquinoline anthelmintic introduced in the 1970s (by BAYER). It is still the most effective and most vastly used parasiticide against tapeworms, but without any efficacy against roundworms, fleas or ticks. Praziquantel adds efficacy against tapeworms (Dipylidium caninum, Taenia pisiformis, etc.) but has no efficacy whatsoever against roundworms, hookworms or whipworms. It is the anthelmintic most vastly used against tapeworms in pets. There are hundreds of antiparasitic brands for pets containing praziquantel.
Pyrantel, oxantel and praziquantel have no residual effect, i.e. they act against the worms during a few hours after administration but are quickly metabolized and excreted. For this reason treatment must often be repeated for certain indications.
For an overview and a list of the most popular pet wormers click here.
This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics.
Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.
In case of doubt contact the manufacturer or a veterinary professional.