Brand: FENPRAL Intestinal Worming Paste for Cats
CHEMICAL CLASS of the active ingredient(s):
PARASITES CONTROLLED* (spectrum of activity):
- Roundworms (Toxocara cati, Toxascaris leonina), hookworms (Ancylostoma spp, Uncinaria stenocephala)
- Tapeworms (Dipylidium caninum, Taenia spp)
- Each 2 kg graduation of the syringe delivers 1ml paste for every 2 kg bw (equivalent to 57.6 mg/kg pyrantel embonate, 150 mg/kg niclosamide).
* Can be slightly different in some countries: read the product label!
- LD50 (acute oral) in rats: n.a. for the paste; >5000 mg/kg for pyrantel; >5000 mg/kg for niclosamide
- Estimated Hazard Class according to the WHO: not applicable for veterinary medicines
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Risk of resistance development? VERY LOW
Are the active ingredients of this product ORIGINAL* or GENERICS**?
- Pyrantel: GENERIC (introduced in the 1960s)
- Niclosamide: GENERIC (introduced in the 1950s)
*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.
COUNTRIES where this product is marketed: AUSTRALIA
GENERIC BRANDS available? YES, in some countries.
Click here to learn more about GENERIC vs. ORIGINAL drugs.
Pyrantel is a narrow-spectrum anthelmintic belonging to the chemical class of the tetrahydropyrimidines that was introduced in the 1960s (by PFIZER → ZOETIS). It is effective against roundworms and a few tapeworms (depending on the dose) in the gut, but not against those in other organs (e.g. the lungs, the skin, etc). It controls important cat worms such as the roundworms Toxocara cati and Toxascaris leonina, the hookworms Ancylostoma spp and Uncinaria stenocephala. It is used a lot in pets and horses but rarely in livestock. There are dozens of products for pets with generic pyrantel.
Niclosamide is another veteran, narrow-spectrum salicylanilide anthelmintic introduced in the 1950s (by BAYER). It is effective against several tapeworm species (e.g. Taenia spp) and rumen flukes (Paramphistomum spp) of livestock, but not against roundworms or any external parasite. It is scarcely used in pets because praziquantel is mostly preferred. Usage in livestock is marginal.
Pyrantel and niclosamide have no residual effect, i.e. they act against the worms during a few hours after administration but are quickly metabolized and excreted. For this reason treatment must often be repeated for certain indications.
For an overview and a list of the most popular pet wormers click here.
This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics.
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