Dosing recommendations for antiparasitics depend on national regulations. ons. National regulatory authorities determine whether a product is approved for a given indication, i.e. use on a particular host at a specific dose and against a specific parasiteCheck the labels of the products available in your country for specific information on approved indications.

The table below indicates some usual dosing recommendations for levamisole issued by manufacturers or documented in the scientific literature. They may not be approved in some countries.

Levamisole is a broad spectrum anthelmintic effective against roundworms (both gastrointestinal and respiratory) but not against tapeworms or flukes. It is also completely ineffective against external parasites. Worldwide it is used massively in livestock (mainly in drenches, feed additives, injectables and a few pour-ons) and only scarcely in pets (often in tablets, pills, etc. or oral suspensions). There are hundreds of generic brands worldwide, many in mixtures with other anthelmintics.

Oral administration reaches higher concentrations in the digestive tract which improves efficacy against gastrointestinal roundworms. Against respiratory roundworms injectables ensure a better bioavailability and higher plasmatic concentrations.

In dogs, delivery with the food or immediately after reduces absorption, resulting in lower plasmatic levels and bioavailability. Fasting for 12 hours fasting to treatment increases levamisole efficacy but also the risk of side effects.

Levamisole (by all delivery forms) has almost no residual effect, i.e. it kills the parasites during a few hours after treatment but offers no significant protection against re-infestation.

Dosing recommendations for LEVAMISOLE
DOGS
Delivery Parasites Dose (against levamisole-susceptible parasites)
Intramuscular Roundworms 5 mg/kg
Oral Gastrointestinal roundworms 5-16 mg/kg
Oral Trichuris vulpis
16 mg/kg
Oral Respiratory roundworms 7.5 mg/day x 2 days
Oral Crenosoma vulpis 8 mg/kg
Oral Capillaria aerophila 7-12 mg/kg/day, x 3-7 days
Oral Filaroides osleri 7.5-12 mg/kg/dayx 10-45 days
Oral Dirofilaria immitis, microfilariae 10 mg/kg/day x 6-12 days
Oral Dirofilaria immitis, adults 10 mg/kg 2x/day, x14 days
Oral Angiostrongylus vasorum 5-10 mg/kg/day x 2 days
Subcutaneous Filaroides osleri 7.5 mg/kg/day x 30 days
Subcutaneous Roundworms 5 mg/kg
CATS
Delivery Parasites Dose (against levamisole-susceptible parasites)
Intramuscular Roundworms 5 mg/kg
Oral Roundworms 7.5 mg/kg
Oral Respiratory roundworms 25 mg/kg/day every other day, 10-14 days
Oral Aelurostrongylus abstrusus 20-40 mg/kg/day every other day, 5-6 treatments
Oral Capillaria aerophila 5 mg/kg/day x5 days, rep 2x with 9 days interval
Oral Dirofilaria immitis, microfilariae 10 mg/kg/day x7 days
Subcutaneous Gastrointestinal roundworms 8 mg/kg
Subcutaneous Capillaria aerophila 4.4 mg/kg/day x2 days + 8.8 mg/kg 2 weeks later
Subcutaneous Aelurostrongylus abstrusus 7.5 mg/kg/day x2 days
CATTLE
Delivery Parasites Dose (against levamisole-susceptible parasites)
Topical Roundworms 10 mg/kg (pour-on)
Intramuscular Roundworms 5 mg/kg
Oral Roundworms 7.5 mg/kg
Oral Dictyocaulus viviparus 5-11 mg/kg
Oral Thelazia spp 5.4-11.9 mg/kg
Subcutaneous Roundworms 5 mg/kg
Subcutaneous Dictyocaulus viviparus 3.8-8 mg/kg
Subcutaneous Ostertagia ostertagi 7 mg/kg
SHEEP  
Delivery Parasites  Dose (against levamisole-susceptible parasites)
Intramuscular Roundworms  5 mg/kg
Oral Roundworms 7.5 mg/kg
Oral  Dictyocaulus spp 8 mg/kg 
Subcutaneous Roundworms 5 mg/kg
GOATS
Delivery Parasites  Dose (against levamisole-susceptible parasites)
Intramuscular Roundworms  5 mg/kg
Oral Roundworms  7.5-12 mg/kg
Oral Dictyocaulus spp 8 mg/kg 
Subcutaneous Roundworms  5 mg/kg  
SWINE 
Delivery Parasites  Dose (against levamisole-susceptible parasites)
Intramuscular Roundworms 5 mg/kg 
Oral Roundworms 7.5-10 mg/kg in feed or water
Subcutaneous Metastrongylus apri 5 mg/kg 
Subcutaneous Strongyloides ransomi 5 mg/kg
HORSES
Delivery Parasites  Dose (against levamisole-susceptible parasites)
Intramuscular Dictyocaulus arnfieldi 55 mg/kg, rep after 3-4 weeks
Oral Roundworms 7.5-15 mg/kg
Subcutaneous Roundworms 5-10 mg/kg
SOUTH AMERICAN CAMELIDS
Delivery Parasites  Dose (against levamisole-susceptible parasites)
Oral Roundworms 5-8 mg/kg
Subcutaneous Roundworms 5-8 mg/kg
POULTRY
Delivery Parasites Dose (against levamisole-susceptible parasites)
Intramuscular Gastrointestinal roundworms 4-8 mg/kg, rep 10-14 days later
Oral Gastrointestinal roundworms 180-541 mg/l water x1-3 days, rep 10 days later
Oral Ascarids 10,8 mg/l water during several weeks
Oral Heterakis spp 40 mg/kg/day x 3 days
Oral Capillaria spp 40 mg/kg/day x 7 days
Subcutaneous Gastrointestinal roundworms 4-8 mg/kg, rep 10-14 days later
RABBITS
Delivery Parasites Dose (against levamisole-susceptible parasites)
Oral Roundworms 12.5-20 mg/kg
Subcutaneous Roundworms 8-20 mg/kg

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