Dosing recommendations for antiparasitics depend on national regulations. National regulatory authorities determine whether a product is approved for a given indication, i.e. use on a particular host at a specific dose and against a specific parasite. Check the labels of the products available in your country for specific information on approved indications.

The table below indicates some usual dosing recommendations for pyrantel issued by manufacturers or documented in the scientific literature. They may not be approved in some countries.

Pyrantel is a narrow-spectrum anthelmintic effective against gastrointestinal roundworms but not against those in the lungs or elsewhere in the host's body. At higher doses it is also effective against certain tapeworms as well. It is ineffective against flukes (e.g. Fasciola hepatica). It is completely ineffective against external parasites. Oral administration is the rule. It is used very scarcely in livestock but quite a lot in pets (often in tablets, pills, etc. or oral suspensions) and horses (mostly in oral pastes & gels). There are hundreds of generic brands worldwide, also in mixtures with other anthelmintics.

Pyrantel is used in the form of different salts, e.g. chlorhydrate, tartrate and pamoate (=embonate). Efficacy depends on the content of so-called "pyrantel base". 10 mg pyrantel base correspond to 11.5 mg pyrantel chlorhydrate; 17.22 mg pyrantel tartrate; and 29 mg pyrantel pamoate (=embonate). The tartrate is water-soluble but is unstable in solutions. The pamoate (=embonate) is not soluble in water. 

In carnivores (incl. dogs and cats) delivery with the food increases the bioavailability of pyrantel resulting in a better efficacy.

Pyrantel has almost no residual effect, i.e. it kills the parasites during a few hours after treatment but offers no significant protection against re-infestation.

Dosing recommendations for PYRANTEL
DOGS
Delivery Parasites Dose (against pyrantel-susceptible parasites)
Oral (base) Gastrointestianl roundworms 5 mg/kg; rep after 1 week against Ancylostoma spp
Oral (pamoate) Gastrointestianl roundworms 14.5 mg/kg (= 5 mg/kg base); rep after 1 week against Ancylostoma spp
Oral (base) Toxocara canis, puppies
5 mg/kg on days 10, 20 & 30 after birth. In puppies of large breeds 7,5 mg/kg.
Oral (pamoate) Ancylostoma, Uncinaria, puppies
14.5 mg/kg (= 5 mg/kg base) 30 min after a light meal. In high-risk puppies 1 weel after birth tras el parto + every 2 weeks during 5-8 weeks
CATS
Delivery Parasites Dose (against pyrantel-susceptible parasites)
Oral (base) Gastrointestianl roundworms 20-30 mg/kg, rep after 1 week if needed
Oral (pamoate) Gastrointestianl roundworms 57.7 mg/kg (=20 mg/kg base), rep after 1 week if needed
CATTLE
Delivery Parasites Dose (against pyrantel-susceptible parasites)
Oral (base) Gastrointestinal roundworms 6.5-13 mg/kg
Oral (tartrate) Gastrointestinal roundworms 25 mg/kg (= 13 mg/kg base)
SHEEP & GOATS
Delivery Parasites  Dose (against pyrantel-susceptible parasites)
Oral Gastrointestinal roundworms 13-25 mg/kg
Oral (tartrate) Gastrointestinal roundworms 20-50 mg/kg
SWINE 
Delivery Parasites  Dose (against pyrantel-susceptible parasites)
Oral (tartrate) Gastrointestinal roundworms 22-25 mg/kg; max 2 g/animal
Oral (tartrate) Oesophagostomum spp 22 mg/kg or 800 g/ton of feed
Oral (tartrate) Ascaris suum 96 g/ton of feed or 2.6 mg/kg/day during 3 days
HORSES
Delivery Parasites  Dose (against pyrantel-susceptible parasites)
Oral (base) Gastrointestinal roundworms 6.6-7.2 mg/kg
Oral (base) Tapeworms 6.6-13.2 mg/kg
Oral (pamoate) Gastrointestinal roundworms 19 mg/kg (= 6.6 mg/kg base)
Oral (pamoate) Tapeworms 38 mg/kg (= 13.2 mg/kg base)
Oral (tartrate) Gastrointestinal roundworms 12.5 mg/kg (= 7.2 mg/kg base)
SOUTH AMERICAN CAMELIDS
Delivery Parasites  Dose (against pyrantel-susceptible parasites)
Oral (pamoate) Gastrointestinal roundworms 18 mg/kg
POULTRY
Delivery Parasites Dose (against pyrantel-susceptible parasites)
Oral (pamoate) Gastrointestinal roundworms 4.5 mg/kg, rep after 14 days
Oral (tartrate) Gastrointestinal roundworms 20-60 mg/kg
Oral (tartrate) Ascaridia galli, L3-larvae 75-125 mg/kg

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