OXFENDAZOLE DOSE for DOGS, CATS, HORSES, CATTLE, SHEEP, GOATS, SWINE and other domestic animals

Oxfendazole is a broad-spectrum anthelmintic effective against roundworms and, depending on the dose also against some tapeworms (e.g. Moniezia spp) as well. It is ineffective against flukes (e.g. Fasciola hepatica adults) and against external parasites. Oral administration is the rule. It is used moderately in livestock (mainly in drenches) and horses (mostly in oral pastes & gels) but very scarcely in pets.

In ruminants, a 50% reduction of the diet 36 prior and 8 hours after treatment slows down the passage through the stomach, which increases the bioavailability of benzimidazoles and their metabolites and consequently its efficacy against gastrointestinal parasites.

In carnivores (incl. dogs and cats) delivery with the food increases the bioavailability of all benzimidazoles resulting in a better efficacy.

All benzimidazoles have almost no residual effect, i.e. they kill the parasites during a few hours after treatment but offer no significant protection against re-infestation.

The table below indicates some usual dosing recommendations for oxfendazole issued by manufacturers or documented in the scientific literature. They may not be approved in some countries.

Dosing recommendations for OXFENDAZOLE
DOGS
Delivery Parasites Dose (against oxfendazole-susceptible parasites)
Oral Gastrointestianl roundworms 10 mg/kg/day x3 days
Oral Toxocara canis, somatic larvae
 100 mg/kg/day from day 30 of pregnancy until birth
Oral Ancylostoma caninum, somatic larvae 100 mg/kg/day from day 30 of pregnancy until birth
Oral Filaroides osleri 10 mg/kg/day x28 days
Oral  Trichuris vulpis 10 mg/kg/day x3 days
CATS
Delivery Parasites Dose (against oxfendazole-susceptible parasites)
Oral Ollulanus tricuspis 10 mg/kg 2x/day x3 days
CATTLE
Delivery Parasites Dose (against oxfendazole-susceptible parasites)
Oral Gastrointestinal roundworms 4.5-5 mg/kg
Oral Ostertagia ostertagi inhibited larvae 5-6.75 mg/kg
Oral Dictyocaulus viviparus 2.5-5 mg/kg
Oral Moniezia spp 5 mg/kg
SHEEP  
Delivery Parasites  Dose (against oxfendazole-susceptible parasites)
Oral Gastrointestinal roundworms 4.5-5 mg/kg
Oral Dictyocaulus filaria 4.5-5 mg/kg
Oral Moniezia spp 4.5-5 mg/kg
GOATS
Delivery Parasites  Dose (against oxfendazole-susceptible parasites)
Oral Gastrointestinal roundworms 7.5 mg/kg
Oral  Muellerius capillaris 10 mg/kg
SWINE 
Delivery Parasites  Dose (against oxfendazole-susceptible parasites)
Oral Gastrointestinal roundworms 3-4.5 mg/kg
Oral Ascaris suum 3 mg/kg
Oral Metastrongylus spp 4.5 mg/kg
Oral Trichuris suis 9 mg/kg
HORSES
Delivery Parasites  Dose (against oxfendazole-susceptible parasites)
Oral Gastrointestinal roundworms 10 mg/kg; rep after 48 hours if needed
Oral Oxyuris equi 1.1 mg/kg
Oral Strongylus spp (migrating larvae)
 10 mg/kg; rep after 48 hours if needed
Oral Thelazia lacrimalis 10 mg/kg; rep after 48 hours if needed
SOUTH AMERICAN CAMELIDS
Delivery Parasites  Dose (against oxfendazole-susceptible parasites)
Oral Gastrointestinal roundworms 5 mg/kg

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Dosing recommendations for antiparasitics depend on national regulations. National regulatory authorities determine whether a product is approved for a given indication, i.e. use on a particular host at a specific dose and against a specific parasite. Check the labels of the products available in your country for specific information on approved indications.

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