Brand: CYDECTIN ® PLUS FLUKE
CHEMICAL CLASS of the active ingredient(s):
PARASITES CONTROLLED (spectrum of activity)
- Roundworms: Triclabendazole susceptible Liver fluke, late immature (6 to 8 weeks) and adult): Fasciola hepatica
- Moxidectin susceptible Gastrointestinal (adult and larval L4): Small Brown Stomach Worm (Ostertagia ostertagi), Stomach Hair Worm (Trichostrongylus axei) and Small Intestinal Worm (Cooperia spp.).
- Moxidectin susceptible Gastrointestinal (adult): Barbers Pole Worm (Haemonchus placei), Nodule worm (Oesophagostomum spp.), Thin-necked Intestinal Worm (Nematodirus spp.) and Hookworm (Bunostomum spp.)
- LD50 (acute oral) in rats:
- moxidectin: a.i. 106 mg/kg (according to MSDS)
- triclabendazole: a.i. >4000 mg/kg (according to MSDS)
- LD50 (acute dermal) in rats:
- moxidectin: a.i. >2000 mg/kg (according to MSDS)
- triclabendazole: a.i. >4000 mg/kg (according to MSDS)
- Estimated hazard class according to the WHO: not applicable for veterinary medicines
Withholding periods (=withdrawal times) in days for meat & milk (country-specific differences may apply: read the product label)
- Meat: Australia 50 days (ESI 160 days)
- Milk for human consumption: Do not use in female sheep which are producing, or may in the future produce, milk or milk products for human consumption
WARNING !!!: Never use on humans, dogs or cats
You may be interested in the following articles in this site dealing with the general safety of veterinary products:
- Safety for humans
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- Hazard classifications of pesticides
Risk of resistance of gastrointestinal roundworms to macrocyclic lactones (incl. moxidectin): YES, reported in gastrointestinal roundworms in cattle in several countries particularly in the following worm species: Cooperia spp and Ostertagia spp.
Resistance of gastrointestinal roundworms to macrocyclic lactones in sheep, goats and cattle has been reported in numerous countries. Most cases have been reported for ivermectin, and moxidectin often works well against ivermectin-resistant worms initially. But if moxidectin use continues gastrointestinal roundworms will become resistant to it rather quickly. Based on the very abundant and frequent use of ivermectin and other macrocyclic lactones in livestock (with more-or-less cross-resistance to ivermectin) it must be assumed that resistance of gastrointestinal roundworms to this chemical class will continue spreading and strengthening in the future.
- Benzimidazoles, e.g. albendazole, febantel, fenbendazole, oxfendazole, etc. Similar or even worse resistance problems than ivermectin
- Imidazothiazoles, mainly levamisole. etc. Similar or even worse resistance problems than ivermectin
- Nitroxinil (limited spectrum of activity)
- Tetrahydropyrimidines, e.g. morantel, pyrantel (limited spectrum of activity)
- Salicylanilides, e.g. closantel (limited spectrum of activity)
Risk of resistance of Fasciola hepatica to triclabendazole: YES. Resistance of liver flukes to triclabendazole (and albendazole) has been reported in cattle in several countries (e.g. Australia, The Netherlands, Argentina). However, the incidence so far is not that serious as for roundworm resistance to benzimidazoles and other nematicides. Nevertheless, in certain regions products with triclabendazole may not protect livestock adequately against liver flukes.
- Closantel (salicylanilide): In sheep effective only against ≥8 weeks old liver flukes.
- Clorsulon: In sheep effective only against ≥8 weeks old liver flukes.
- Nitroxinil: In sheep effective only against ≥8 weeks old liver flukes.
- Oxyclozanide (salicylanilide): In sheep effective only against ≥12 weeks old liver flukes.
- Rafoxanide (salicylanilide): In sheep effective only against ≥6 weeks old liver flukes.
These alternative products may not be available in all countries, or may not be available as drenches.
This means that if this product does not achieve the expected efficacy against the mentioned parasites, it may be due to resistance and not to incorrect use, which is usually the most frequent cause of product failure.
Are the active ingredients of this product ORIGINAL* or GENERICS**?
*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.
COUNTRIES where this brand/product is marketed: Australia, New Zealand
GENERIC BRANDS available? Yes a few ones, perhaps not with the same composition.
Click here to learn more about GENERIC vs. ORIGINAL drugs.
For an overview on the most used antiparasitic pour-on brands click here.
CYDECTIN PLUS FLUKE Pour-on for Cattle is a combination of moxidectin (mainly nematicide) with generic triclabendazole (only flukicide). It is marketed by VIRBAC in Australia and by ZOETIS in New Zealand.
Moxidectin is a veteran macrocyclic lactone introduced in the 1990s (by AMERICAN CYANAMID). It is generally considered as more potent than ivermectin against gastrointestinal nematodes of livestock, particularly in sheep and goats, and against a few other livestock pests (e.g. sheep scab, cattle ticks, etc.), although the drench formulation is not effective against most external parasites. It is also less toxic than ivermectin, which makes it possible to use it at higher rates, particularly in long-acting formulations. As all macrocyclic lactones, moxidectin used alone is ineffective against tapeworms and flukes, regardless of the delivery form.
Triclabendazole is a veteran flukicide introduced in the 1970s (by CIBA-GEIGY). It was and remains the only flukicide effective against adults as well as all immature stages of liver flukes, which are the most damaging stages due to their destructive migration through the liver tissues. For this reason it has been for decades and still remains the most widely used livestock flukicide worldwide. In contrast with all other benzimidazoles, triclabendazole has no efficacy whatsoever on roundworms, tapeworms or any external parasites (ticks, flies, lice, mites, etc) of livestock.
As all benzimidazoles (and many other anthelmintics such as levamisole, monepantel, and tetrahydropyrimidines), triclabendazole administered as a drench has no residual effect, i.e. it kills the parasites shortly after administration, but does not significantly protect the animals against re-infestation by infective stages in their environment.
In ruminants, reducing the amount of feed slows down the exit flow of the rumen and prolongs the time during which the active ingredient remains there and is absorbed. Consequently it is advisable to reduce the access of animals to feed (especially to fresh pasture, not to water) 24 hours before administration. For the same reason, it is better to keep the animals away from food for about 6 hours after drenching. However sick or weak animals should not be kept away from food and fasting animals should have access to water.
This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics.
Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.
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