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Brand: FLUKAZOLE ® C PLUS SELENIUM

Company: VIRBAC


FORMULATION: «drench» for oral administration.

ACTIVE INGREDIENT(S):

  • Oxfendazole: 45.3 g/L (=4.53%)
  • Triclabendazole: 120 g/L (=12%)
  • Selenium (as sodium selenate): 1 g/L (0.1%): no anthelmintic efficacy

CHEMICAL CLASS of the active ingredient(s): benzimidazoles


INDICATIONS: SHEEP

PARASITES CONTROLLED (spectrum of activity)

Cattle

Sheep & Goats


RECOMMENDED DOSE


SAFETY

  • LD50 (acute oral) in rats:
    • oxfendazole >6400 mg/kg (according to MSDS)
    • triclabendazole: a.i. >8000 mg/kg (according to MSDS)
  • LD50 (acute dermal) in rats:
    • oxfendazole a.i. n.a.
    • triclabendazole: a.i. >4000 mg/kg (according to MSDS)
  • Estimated hazard class according to the WHO: not applicable for veterinary medicines

Suspected poisoning? Read the articles on oxfendazole safety and/or triclabendazole safety in this site.

Withholding periods (=withdrawal times) in days for meat & milk (country-specific differences may apply: read the product label)

  • Meat: 21 days (ESI Cattle 56 days; Sheep 63 days )
  • Milk for human consumption: Do not use in animals, which are producing milk or milk products for human consumption. Do not use less than 21 days before calving in cows or lambing in ewes where milk or milk products from treated animals may be used for human consumption. Calves fed this milk should not be slaughtered for human consumption within 10 days. Lambs fed this milk should not be slaughtered for human consumption within 7 days.

WARNING !!!: Never use on humans, dogs or cats

You may be interested in the following articles in this site dealing with the general safety of veterinary products:


RESISTANCE PREVENTION

Risk of resistance? YES, resistance of gastrointestinal roundworms to all benzimidazoles (incl. oxfendazole) in ruminants is a very serious and increasing problem worldwide, particularly in sheep and goats, but also in cattle. The most affected worm species are:

This means that if this product does not achieve the expected efficacy against the mentioned parasites, it can be due to resistance and not to incorrect use, which is usually the most frequent cause of product failure.

Alternative chemical classes/active ingredients to prevent resistance of gastrointestinal roundworms through product rotation:

Risk of resistance of Fasciola hepatica to triclabendazole: YES. Resistance of liver flukes to triclabendazole (and albendazole) in sheep was already discovered in the mid 1990's in Australia. Since then it has been reported in several other countries (e.g. New Zealand, UK, Ireland, Spain, Argentina), also in cattle (e.g. Australia, The Netherlands, Argentina). However, the incidence so far is not that serious as for roundworm resistance to benzimidazoles and other nematicides. Nevertheless, in certain regions products with triclabendazole may not protect livestock adequately against liver flukes.

Alternative chemical classes/active ingredients to prevent resistance of liver flukes through product rotation:

This means that if this product does not achieve the expected efficacy against the mentioned parasites, it may be due to resistance and not to incorrect use, which is usually the most frequent cause of product failure.

Alternative products may not be available in all countries, or may not be available as drenches.

Learn more about resistance and how it develops.


MARKETING

Are the active ingredients of this product ORIGINAL* or GENERICS**?

  • GENERICS

*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.

COUNTRIES where this brand/product is marketed: Australia.
GENERIC BRANDS available? Yes a few ones, perhaps not with the same composition. This product itself contains generic osfendazole and triclabendazole.

Click here to learn more about GENERIC vs. ORIGINAL drugs.

For an overview on the most used antiparasitic pour-on brands click here.


COMMENTS

FLUKAZOLE C PLUS SELENIUM from VIRBAC is a combination of oxfendazole (mainly nematicide) with generic triclabendazole (only flukicide).

All benzimidazoles are veteran anthelmintics. Oxfendazole was introduced in the 1970s (by WELLCOME, SYNTEX). It has a broad-spectrum of activity against roundworms (gastrointestinal and pulmonary) & tapeworms, but is ineffective against flukesOxfendazole also kills eggs of roundworms (ovicidal activity). As all benzimidazolesoxfendazole has no efficacy whatsoever against external parasites (ticksflies, lice, mites, etc). Among the benzimidazoles oxfendazole is quite comparable with fenbendazole in terms of efficacy and safety. It is moderately used in livestock and horses, rather scarcely in pets, and not at all in agriculture.

Triclabendazole is a veteran flukicide introduced in the 1970s (by CIBA-GEIGY). It was and remains the only flukicide effective against adults as well as all immature stages of liver flukes, which are the most damaging stages due to their destructive migration through the liver tissues. For this reason it has been for decades and still remains the most widely used livestock flukicide worldwide. In contrast with all other benzimidazoles, triclabendazole has no efficacy whatsoever on roundwormstapeworms or any external parasites (ticksflies, lice, mites, etc) of livestock.

Because it is effective against all stages of immature flukes, triclabendazole is appropriate for treating acute fascioliasis caused my massive infections with fluke larvae migrating through the liver.

As all benzimidazoles (and many other anthelmintics such as levamisole, monepantel, and tetrahydropyrimidines), oxfendazole and  triclabendazole administered as a drench have no residual effect, i.e. they kill the parasites shortly after administration, but do not significantly protect the animals against re-infestation by infective stages in their environment.

The combination of oxfendazole and triclabendazole makes sense because it extends the spectrum of activity of both active ingredients.

In ruminants, reducing the amount of feed slows down the exit flow of the rumen and prolongs the time during which the active ingredient remains there and is absorbed. Consequently it is advisable to reduce the access of animals to feed (especially to fresh pasture, not to water) 24 hours before administration. For the same reason, it is better to keep the animals away from food for about 6 hours after drenching. However sick or weak animals should not be kept away from food and fasting animals should have access to water.


DISCLAIMER

This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics. 

Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.

In case of doubt contact the manufacturer or a veterinary professional.

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