Brand: RFD ® LIQUID WORMER

Company: ZOETIS


FORMULATION: «oral suspension» for oral administration

ACTIVE INGREDIENT(S): PYRANTEL (as pamoate salt): 2.27 mg/mL (pyrantel base)

CHEMICAL CLASS of the active ingredient(s): TETRAHYDROPYRIMIDINE


INDICATIONS: DOGS


PARASITES CONTROLLED* (spectrum of activity):


RECOMMENDED DOSE*:

USA and other countries

  • 1 mL suspension contains 2.27 mg pyrantel base
  • Administer one teaspoon (5 mL) for each 5 lb (≈ 2.27 kg) bw, corresponding to a dose of 5.0 mg/kg

* Can be slightly different in some countries: read the product label!


SAFETY

  • LD50 (acute oral) in rats: >5000 mg/kg for pyrantel pamoate a.i.
  • Estimated Hazard Class according to the WHO: not applicable for veterinary medicines

Suspected poisoning? Read the article on pyrantel safety in this site.

Never use on cats products approved only for use on dogs, and vice-versa.

You may be interested in the following articles in this site dealing with the general safety of veterinary products:


RESISTANCE PREVENTION

Risk of resistance development? YES, but rather low in Ancylostoma caninum.

There are reports on resistance of Ancylostoma spp to pyrantel in dogs and horses, but so far it does not seem to be widespread.

Alternatives to prevent resistance through product rotation:

Learn more about resistance and how it develops.


MARKETING

Are the active ingredients of this product ORIGINAL* or GENERICS**?

  • Pyrantel: GENERIC (introduced in the 1960s)

*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.

COUNTRIES where this product is marketed: USA.
GENERIC BRANDS available? YES, numerous in several countries.

Click here to learn more about GENERIC vs. ORIGINAL drugs.


COMMENTS

RFD LIQUID WORMER is a classic dog anthelmintic from ZOETIS with pyrantel pamoate

Pyrantel is a narrow-spectrum anthelmintic belonging to the chemical class of the tetrahydropyrimidines that was introduced in the 1960s (by PFIZER → ZOETIS). It  is effective against roundworms and a few tapeworms (depending on the dose) in the gut, but not against those in other organs (e.g. the lungs, the skin, etc). It adds efficacy against important dog worms such as the roundworms Toxocara canis and Toxascaris leonina, the hookworms Ancylostoma caninum and Uncinaria stenocephala. It is used a lot in pets and horses but rarely in livestock. There are dozens of products for pets with generic pyrantel.

Pyrantel has no residual effect, i.e. it acts against the worms during a few hours after administration but is quickly metabolized and excreted. For this reason treatment must often be repeated for certain indications. This is in contrast with wormers containing macrocyclic lactones (e.g. milbemycin oxime, selamectin) that ensure efficacy against numerous roundworms during weeks after a single treatment.

For an overview and a list of the most popular pet wormers click here.


DISCLAIMER

This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics. 

Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.

In case of doubt contact the manufacturer or a veterinary professional.

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