Brand: TRIFORCE CANINE SQUEEZE-ON

Company: TRADEWINDS


FORMULATION: «spot-on» solution for topical administration on the back of the animals (also called pipettes, squeeze-ons, drop-ons, etc.)

ACTIVE INGREDIENT(S):

CHEMICAL CLASS of the active ingredient(s):


INDICATIONS: DOGS


PARASITES CONTROLLED* (spectrum of activity)

* Can be slightly different in some countries: read the product label!


RECOMMENDED DOSE

  • For Small Dogs 9 to 20 lbs: Apply one tube (1.5 mL) from the back of the neck to a point midway between the neck and tail.
  • For Medium Dogs 21 to 39 lbs: Apply one tube (3.0 mL) from the back of the neck to a point midway between the neck and tail.
  • For Large Dogs 40 to 60 lbs: Apply one tube (4.5 mL) from the back of the neck to a point midway between the neck and tail.
  • For Medium Dogs >60 lbs: Apply one tube (6.0 mL) from the back of the neck to a point midway between the neck and tail.

SAFETY

  • LD50 (acute oral) in rats: Cypenothrin 318 mg/kg; Pyriproxyfen >5000 mg/kg.
  • LD50 (acute dermal) in rats: Cypenothrin >5000 mg/kg; Pyriproxyfen >2000 mg/kg.

Suspected poisoning? Read the article on cyphenothrin safety in this site. Pyriproxyfen is an insect development inhibitor virtually non-toxic to dogs, cats, humans and other mammals.

WARNING !!!: Never use on cats pipettes approved only for dogs. Cyphenothrin is toxic to cats! Never use on small dogs pipettes approved for large dogs. Learn more about spot-ons and their safety.

You may be interested in the following articles in this site dealing with the general safety of veterinary products:


RESISTANCE PREVENTION

Risk of resistance? YES:

Resistance to pyrethroids (including cyphenothrin) is common in fleas and mosquitoes worldwide. Mosquito resistance is mostly due to large scale spraying of pyrethroids for vector control or pest control in agriculture.

Resistance of brown dog ticks (Rhipicephalus sanguineus) to permethrin and other pyrethroids is not uncommon in many countries, including the USA.

As a consequence protection provided by this product against fleas, mosquitoes and brown dog ticks may be lower or shorter than expected.

Alternatives to prevent resistance through product rotation:

*F = effective against fleas; T = effective against ticks.

These alternative products may not be available in all countries, or may not be available as spot-ons.

Resistance of fleas, mosquitoes, brown dog ticks to carbamates and organophosphates is not uncommon in several countries, including the USA.

Learn more about resistance and how it develops.


MARKETING

Are the active ingredients of this product ORIGINAL* or GENERICS**?

  • Cyphenothrin: GENERIC (introduced in the 1980s)
  • Pyriproxyfen: GENERIC (introduced in the 1980s)

*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.

COUNTRIES where this product is marketed (maybe under another TM): USA
GENERIC BRANDS available? YES. This product contains generic cyphenothrin and pyriproxyfen.

Click here to learn more about GENERIC vs. ORIGINAL drugs.


COMMENTS

TRIFORCE CANINE SQUEEZE-ON from TRADEWINDS is one among many flea+tick spot-on for dogs with synthetic pyrethroids.

Cyphenothrin is a veteran broad-spectrum pyrethroid insecticide and acaricide introduced in the 1980s (by SUMITOMO). It is moderately used in agriculture as well as in public and domestic hygiene, but only scarcely in pets. It is not used at all in livestock. It is effective against fleas, ticks and mosquitoes.

Pyriproxyfen (Nylar) is a veteran insect development inhibitor introduced in the 1980s (by SUMITOMO) scarcely used in pets and not at all in livestock. It is also used moderately in agriculture and for vector control. In this product it stops development of flea eggs and larvae. It has no protective effect whatsoever against fleas, ticks or mosquitoes. The logic of combining it with cyphenothrin is to ensure that if a few fleas survive the killing effect of cyphenothrin (what usually happens) development of their offspring is inhibited, because the eggs of the surviving fleas will not develop further.

This combination of two active ingredients of different chemical classes makes also sense regarding resistance prevention, because it means attacking fleas through two different mechanisms of action, which is vastly assumed to help preventing or at least delaying resistance development.

Topical products (mainly spot-ons and insecticide-impregnated collars) have some advantages over systemic products (mainly tablets for oral administration and injectables):

  • Most topical products kill or sterilize the parasites before they bite and suck blood on the pet, whereas systemic products kill or sterilize the parasites only after their blood meal.
  • Topical products cannot be vomited.
  • Spot-ons and collars are very convenient to administer.
  • There is a larger choice of topical products.

But topical products have also some disadvantages:

  • Topical products contaminate the pet's hair coat and it is advisable for children and also adults to avoid contact with the pet for several days after treatment.
  • Topical products may not control parasites in some parts of the pet's body (e.g. the ears, below the tail, between the legs, etc.), whereas systemic products reach the blood-sucking parasites through the blood wherever they are.
  • Efficacy of topical products may be reduced or shortened through exposure to dirt, sun, shampooing, washing, rain, baths, etc., whereas efficacy of systemic products is independent from these factors.

This product is one of many examples of a questionable practice regarding the use of pyrethroids at very high concentrations in pets, mainly in dogs. Photostable pyrethroids (including permethrin, cypermethrin, deltamethrin, cyphenothrin, phenothrin, etc.) can have a dose-dependent irritant effect on mammals. Most of them are toxic to cats at the therapeutic dose used on dogs. Pyrethroid-related irritation is a well-known problem in livestock. Ready-to-use pour-ons are frequently used on cattle, comparable to ready-to-use spot-ons por dogs, but usually at a concentration of 1%-5% active ingredient and at a much lower dose of 1-5 mg/kg. Even at this dose some cattle show signs of irritation, particularly dairy cows and calves. In this particular dog spot-on cyphenothrin is delivered at a concentration of 40.0%, which results in a dose rate of up to ~150 mg/kg for a small dog dog, about 30-100 times more than on cattle. It is not surprising that not all dogs tolerate such a dose, particularly small breeds, puppies and weaker animals (sick, stressed, old). 

A comparable situation occurs with amitraz for dogs (and cats, to which amitraz is also toxic). There are no amitraz ready-to-use pour-ons for cattle, because cattle just don't tolerate it at high concentrations. Instead there are topical amitraz sprays or dips that are applied to cattle at concentrations of ~0.025% (250 ppm = mg/L), which results in a dose of 3-5 mg/kg body weight. Even at this dose cattle may not tolerate amitraz and show undesirable side-effects (sedation, depression, etc). Spot-ons for dogs may contain up to 10% amitraz and can result in doses of up to 45 mg/kg body weight! Chihuahuas and puppies are particularly at risk of amitraz side effects.

It is also not surprising that such products erroneously administered to cats can be deadly.

In fact, serious problems with adverse reactions after use of certain spot-ons have been reported in the USA, especially on cats and small dogs. According to a report by the EPA from 2010, most problems occurred with spot-ons containing permethrin, phenothrincyphenothrin (all are synthetic pyrethroids) and amitraz, not approved for use on cats but erroneously used on them. There have been also numerous overdosing cases of small dogs, apparently because some users buy large vials for large dogs but use them several times in smaller dogs to save money. It seems also that small dogs are more sensitive than large ones and don't support the treatment as well as large ones. It also seems that some insufficiently investigated inert ingredients (e.g. solvents) in the formulations are not as harmless as they were supposed to be.

Deeper information on the misuse of synthetic pyrethroids in dogs and pets can be found in: Anadón et al. 2009. Use and abuse of pyrethrins and synthetic pyrethroids in veterinary medicine. The Veterinary Journal, 182, 7-20.

My personal opinion is that the fierce competition for market share in this largest and most profitable veterinary market has pushed some companies to take too many risks in order to launch products that are "different" to those of their competitors. In fact it has become very difficult to be "new" or really "superior" in a market driven mainly by generic active ingredients during the last decade. Once one company has taken the risk, others will follow and launch their "me-too" brand, to be sure they don't miss an opportunity.

For an overview and a list of the most popular pet antiparasitics for flea, tick, lice and/or mite control click here.


DISCLAIMER

This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics. 

Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.

In case of doubt contact the manufacturer or a veterinary professional.

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