Brand: CLIK™ EXTRA Spray-on / Pour-on (65 mg/mL) for Sheep

Company: ELANCO


FORMULATION: «spray-on/pour-on» for topical administration.

ACTIVE INGREDIENT(S)dicyclanil 65 mg/mL (= 6.5%)

CHEMICAL CLASS of the active ingredient(s): insect growth regulator (= IGR, cyanopyrimidine)


INDICATIONS: SHEEP

PARASITES CONTROLLED* (spectrum of activity)

* Country-specific differences may apply: read the product label.

  • Australia: For the protection of sheep against fly strike (Lucilia cuprina) for up to 29 weeks. For the protection of mulesing and marking wounds on sheep against fly strike during the wound healing process.
  • UK, Ireland & EU: Prevention against blowfly strike on sheep caused by Lucilia spp or Wohlfahrtia magnifica.

RECOMMENDED DOSE*

* Can be slightly different in some countries: read the product label!

Use recommendations (Australia):

Sheep weight (kg) Dose rate (mL/sheep) Vol.per treatment band (mL) Number of bands
Prevention of body & breech strike
10 - 20 10 10 1
21 - 30 12 12 1
31 - 50 15 7.5 2
>50 18 9 2
Prevention of fly strike after mulesing
≤30 8 4 2
31 - 50 10 5 2
Prevention of fly strike after marking
Ram Lambs 8 4 2
Ewe Lambs 4 4 1

Read the product label for further details on dosing and administration.

Use recommendations (UK & Ireland):

Guide dose volumes correspond to 0.6–2 ml [39–130 mg dicyclanil] per kg bodyweight.

Sheep weight (kg) Dose rate (mL)
10 - 20 20
21 - 30 24
31 - 50 30
>50 36

Read the product label for further details on dosing and administration.


SAFETY

  • LD50 (acute oral) in rats: >5000 mg/kg
  • LD50 (acute dermal) in rats: >5000 mg/kg
  • Estimated hazard class according to the WHO classification of pesticides: not listed

Suspected poisoning? Read the article on dicyclanil safety in this site.

Withholding periods (=withdrawal times) for meat, milk & shearing (country-specific differences may apply: read the product label)

  • Meat:
    • Australia: 14 days.
    • UK, Ireland and EU 40 days.
  • Milk for human consumption: Australia, UK, Ireland and EU: Not authorised for use in animals producing milk for human consumption.
  • Wool Harvestig Interval: Australia: 3 months.

WARNING !!!: Never use on humans, dogs or cats.

You may be interested in the following articles in this site dealing with the general safety of veterinary products:


RESISTANCE PREVENTION

Risk of resistance? YES but rather low, mainly in Australia.

It has been shown that houseflies & blowflies resistant to cyromazine (another IGR vastly used for blowfly strike prevention) have some degree of cross-resistance to dicyclanil. However, resistance of blowflies to cyromazine is still quite unusual. It has been reported for Lucilia cuprina in a few locations in Australia, but so far not in the UK, other EU countries, South Africa or New Zealand. In those cases of cyromazine field resistance reported in Australia resistance factors were very low (about 2.3 for cyromazine, 1.3x for dicyclanil) and the concerned products were still providing protection according to registered label claims.

Alternative chemical classes/active ingredients to prevent resistance of blowflies to dicyclanil product rotation:

These alternative products may not be available in all countries, or may not be available as spray-ons/pour-ons.

Learn more about resistance and how it develops.


MARKETING

Are the active ingredients of this product ORIGINAL* or GENERICS**?

  • GENERICS

*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.

COUNTRIES where this brand/product is marketed: Australia, UK, Ireland and other EU countries.
GENERIC BRANDS available? Not yet in this particular formulation.

Click here to learn more about GENERIC vs. ORIGINAL drugs.

For an overview on the most used antiparasitic pour-on brands click here.


COMMENTS

CLIK EXTRA Spray-on/Pour-on for sheep is a follow-up formulation of CLIK, the first and original product containing dicyclanil introduced by NOVARTIS (now ELANCO) in the late 1990s. CLIK EXTRA ensures season long protection (up to 29 weeks) in most regions.

Dicyclanil is an insect development inhibitor with a very specific efficacy againts dipteran larvae. So far it is exclusively used in sheep, and not at all in other livestock, pets or agriculture.

An interesting feature of CLIK is its formulation. It is a suspo-emulsion in water. Since dicyclanil is very poorly soluble in water, it is diluted in small oil droplets, which on their turn are emulsified in water. The practical consequence is that CLIK consist mainly of water instead of organic solvents as most other parasiticides. However, once administerd to sheep, the oily droplets carrying the active ingredient attach to the wool lipids where dicyclanil is dissolve to remain their for weeks.

In some countries NOVARTIS introduced CLIKZIN, a light version of CLIK, i.e. a less concentrated formulation useful when shorter protection periods are required. Also in some countries CLIK PLUS is marketed, a combination of dicyclanil with diflubenzuron that controls and prevents sheep body lice as well.

For those visitors that have reached these depths of parasitipedia.net here's a personal message. I was very heavily involved in the discovery and development of CLiK in the 1990s during my years in NOVARTIS AH. Click here if you want to know more about the discovery and development of CLiK.


DISCLAIMER

This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics. 

Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.

In case of doubt contact the manufacturer or a veterinary professional.

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