Brand: EXITEL ® 230/20 mg Flavoured Film-Coated Tablets for Cats

Company: CHANELLE


FORMULATION: «tablets» for oral administration; may be chewable, flavored, coated, etc, depending on the country

ACTIVE INGREDIENT(S):

CHEMICAL CLASS of the active ingredient(s):


INDICATIONS*: CATS

PARASITES CONTROLLED (spectrum of activity):

Treatment of mixed infections by nematodes and cestodes of the following species:

* Can be slightly different in some countries: read the product label!


RECOMMENDED DOSE*:

Ireland:

  • The recommended dose rates are: 1 tablet per 4 kg bw, equivalent to  20 mg/kg bw pyrantel (equivalent to 57.5 mg/kg pyrantel embonate) and 5 mg/kg bw praziquantel.

Read he product label for further details on dosing.

* Can be slightly different in some countries: read the product label!


SAFETY

  • LD50 (acute oral) in rats: n.a. for the tablets: >5000 mg/kg for pyrantel; 2840 mg/kg for praziquantel
  • Estimated Hazard Class according to the WHO: not applicable for veterinary medicines

Suspected poisoning? Read the articles on pyrantel safety and/or praziquantel safety in this site.

Never use on cats tablets approved only for use on dogs, and vice-versa

You may be interested in the following articles in this site dealing with the general safety of veterinary products:


RESISTANCE PREVENTION

Risk of resistance development? NO

There are reports on resistance of Ancylostoma spp to pyrantel in dogs and horses, but so far it does not seem to be widespread, and the simultaneous administration of a benzimidazole (febantel) with a different mechanism of action than pyrantel should ensure efficacy against potentially pyrantel-resistant worms.

There are no reports on resistance of roundworms to pyrantel, nor of tapeworms to praziquantel in cats.

Learn more about resistance and how it develops.


MARKETING

Are the active ingredients of this product ORIGINAL* or GENERICS**?

  • Pyrantel: GENERIC (introduced in the 1960s)
  • Praziquantel: GENERIC (introduced in the 1970s)

*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.

COUNTRIES where this product is marketed: Ireland and other EU countries.
GENERIC BRANDS available? YES, in many countries. This product itself contains generic active ingredients.

Click here to learn more about GENERIC vs. ORIGINAL drugs.


COMMENTS

EXITEL ® 230/20 mg Tablets for Cats is a generic all-round feline dewormer with generic pyrantel and praziquantel, effective against roundworms and tapeworms. It is a generic version of DRONTAL from BAYER.

Pyrantel is a narrow-spectrum anthelmintic belonging to the chemical class of the tetrahydropyrimidines that was introduced in the 1960s (by PFIZER → ZOETIS). It  is effective against roundworms and a few tapeworms (depending on the dose) in the gut, but not against those in other organs (e.g. the lungs, the skin, etc). It adds efficacy against important dog worms such as the roundworms Toxocara canis and Toxascaris leonina, the hookworms Ancylostoma caninum and Uncinaria stenocephala. It is used a lot in pets and horses but rarely in livestock. There are dozens of products for pets with generic pyrantel. It is not used in agriculture.

Praziquantel is a veteran isoquinoline anthelmintic introduced in the 1970s (by BAYER). It is still the most effective and most vastly used parasiticide against tapeworms, but without any efficacy against roundworms, fleas or ticks. Praziquantel adds efficacy against tapeworms (Dipylidium caninumTaenia pisiformis, Echinococcus granulosusEchinococcus multilocularis) but has no efficacy whatsoever against roundworms, hookworms or whipworms. It is the anthelmintic most vastly used against tapeworms on pets. There are hundreds of antiparasitic brands for pets containing praziquantel. It is also abundantly used in horses, but scarcely in livestock. It is not used in agriculture.

Pyrantel, praziquantel, all the benzimidazoles (e.g. febantel, albendazole, mebendazole, etc.), piperazine, and other anthelmintics have no residual effect, i.e. they act against the worms during a few hours after administration but are quickly metabolized and excreted. For this reason treatment must often be repeated for certain indications. This is in contrast with wormers containing macrocyclic lactones (e.g. milbemycin oxime, selamectin) that ensure efficacy against numerous roundworms during weeks after a single treatment.

For an overview and a list of the most popular pet wormers click here.


DISCLAIMER

This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics. 

Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.

In case of doubt contact the manufacturer or a veterinary professional.

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