Brand: FLEECEMASTER

Company: MERIAL


FORMULATION: concentrate for topical administration to sheep by «dipping» or «jetting»

ACTIVE INGREDIENT(S): Diflubenzuron: 250 g/L (= 25%)

CHEMICAL CLASS of the active ingredient(s): Insect growth regulator (= IGR, benzoylphenyl-urea)


INDICATIONS: SHEEP


PARASITES CONTROLLED * (spectrum of activity)

* Country-specific differences may apply: read the product label.

  • For protection against blowfly strike (incl. Lucilia cuprina) for up to 12 weeks, depending on fly pressure
  • Control of lice.

RECOMMENDED DOSE*

* Country-specific differences may apply: read the product label.

  • Flystrike control
    • Ewes, hoggets and rams: 150 mL product in 100 L water (1:666 dilution, equivalent to 375 ppm = mg/L difubenzuron in the wash).
    • Lambs (moderate flystrike pressure): 150 mL product in 100 L water (1:666 diution equivalent to 375 ppm = mg/L difubenzuron in the wash).
    • Lambs (severe flystrike pressure): 250 mL product in 100 L water (1:400 dilution equivalent to 625 ppm= mg/L difubenzuron in the wash).
  • Lice control
    • Ewes, hoggets, rams, lambs: 150 mL product in 100 L water (1:666 dilution equivalent to 375 ppm = mg/L difubenzuron in the wash).
  • Jetting
    • Ewes, hoggets, rams, lambs: 250 mL product in 100 L water (1:400 diution equivalent to 625 ppm= mg/L difubenzuron in the wash).

Read the product label for further details on dosing and administration.


SAFETY

  • LD50 (acute oral) in rats: >4640 mg/kg for the a.i.
  • Estimated hazard class according to the WHO classification of pesticides: U, unlikely to present acute hazard

Withholding periods (=withdrawal times) for meat, milk & wool (country-specific differences may apply: read the product label)

  • Meat: New Zealand: NIL
  • Milk for human consumption: New Zealand: NIL
  • Wool: New Zealand: 2 months.

WARNING !!!: Never use on humans, dogs or cats.

You may be interested in the following articles in this site dealing with the general safety of veterinary products:


RESISTANCE PREVENTION

Risk of resistance? HIGH

Resistance of blowfly strike to diflubenzuron and other benzoylphenyl-ureas is widespread in Australia and New Zealand. Resistance of body lice (Bovicola = Damalinia ovis) to diflubenzuron and other benzoylphenyl-ureas has been reported in Australia, but seems not be a problem yet in New Zealand.

This means that if this product does not achieve the expected efficacy against the mentioned parasites, it may be due to resistance and not to incorrect use, which is usually the most frequent cause of product failure.

Alternative chemical classes/active ingredients to prevent resistance of through product rotation:

These alternative products may not be available in all countries, or may not be available for dipping, jetting or dressing.

Learn more about resistance and how it develops.


MARKETING

Are the active ingredients of this product ORIGINAL* or GENERICS**?

  • GENERICS

*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.

COUNTRIES where this brand/product is marketed: New Zealand
GENERIC BRANDS available? Yes, several ones in New Zealand and Australia.

Click here to learn more about GENERIC vs. ORIGINAL drugs.

Click here for an overview on the most used antiparasitic BRANDS witoncentrates for dipping, spraying, or jetting.


COMMENTS

FLEECEMASTER for sheep from MERIAL is a classic concentrate for dipping and jetting sheep containing generic diflubenzuron.

Diflubenzuron is a veteran IGR, the first benzoylphenyl-urea, discovered already in the 1970s (by PHILIPS-DUPHAR). It is a so-called Chitin Synthesis Inhibitor (CSI) effective against numerous insect species. It is moderately used in sheep, very scarcely in other livestock but not in pets. It is also moderately used in agricultural pesticides. It was introduced for use as a lousicide in sheep in Australia only in the 1990's (under the TM FLEECARE from HOECHST), when lice developed high resistance to synthetic pyrethroids, which lost approval for lice control. Diflubenzuron and other benzoylphenyl-ureas subsequently conquered the sheep body lice market very quickly in Australia after resistance to synthetic pyrethroids exploded and organophosphates that still worked well were progressively withdrawn for safety reasons.

Chitin is a component of the cuticle of insects, which is an essential part of their outer skeleton. If chitin is not properly produced, larvae die when they attempt the next molt. The consequence is that fly maggots cannot complete molting and die. CSIs such as the benzoylphenyl ureas (BPUs, e.g. diflubenzuron, triflumuron) inhibit chitin synthesis. But they do not immediately kill the fly maggots (larvae), i.e. they have no knockdown effect. Larvae will die at their next attempt to molt to the next developmental stage, which may take 1-4 days to occur, depending on age of the maggots at the time of treatment, humidity, temperature, etc. For this reason, IGRs are usually not used for curing established strikes, but for preventing their development by killing the very small first-stage larvae that hatch out of the eggs deposited by the adult flies on the wool.


DISCLAIMER

This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics. 

Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.

In case of doubt contact the manufacturer or a veterinary professional.

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