Brand: IVOMEC ® 1% injection
Company: BOEHRINGER INGELHEIM (MERIAL)
CATTLE, SHEEP, SWINE (cattle everywhere; sheep & swine depending on the country; in some countries also minor species such as goats, reindeer, bison, etc.)
PARASITES CONTROLLED* (spectrum of activity)
* Country-specific differences may apply: read the product label.
- Gastrointestinal roundworms (adults and L4 larvae): Ostertagia ostertagi (incl. inhibited larvae), Ostertagia lyrata, Haemonchus placei, Trichostrongylus axei, Trichostrongylus colubriformis, Cooperia oncophora, Cooperia punctata, Cooperia pectinata, Oesophagostomum radiatum, Bunostomum phlebotomum, Nematodirus helvetianus (adults only), Nematodirus spathiger (adults only).
- Lungworms (adults and fourth-stage larvae): Dictyocaulus viviparus.
- Eyeworms: Thelazia spp
- Cattle grubs (warbles, parasitic stages): Hypoderma bovis, Hypoderma lineatum.
- Sucking lice: Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus.
- Mites (scabies): Psoroptes ovis (syn. P. communis var. bovis), Sarcoptes scabiei var. bovis
- Aid in the control of: biting lice (Damalinia bovis); mange mites (Chorioptes bovis); cattle ticks Rhipicephalus (Boophilus) microplus in Australia.
- Residual effect (significant country differences: read the product label!):
- Gastrointestinal roundworms: Ascaris suum (adults and L4 larvae), Red stomach worm Hyostrongylus rubidus (adults and L4 larvae), Nodular worm Oesophagostomum spp. (adults and L4 larvae), Threadworm Strongyloides ransomi (adults).
- Somatic roundworm Larvae: Threadworm, Strongyloides ransomi (somatic larvae). Sows must be treated at least seven days before farrowing to prevent infection in piglets.
- Lungworms: Metastrongylus spp (adults).
- Lice: Haematopinus suis.
- Mange mites: Sarcoptes scabiei var. suis.
- Gastrointestinal roundworms: Teladorsagia circumcincta (incl. L4 and inhibited larvae), Ostertagia trifurcata (incl. L4), Haemonchus contortus (incl. L4 and inhibited larvae), Trichostrongylus axei, Trichostrongylus colubriformis (incl. L4), Trichostrongylus vitrinus, Cooperia curticei (incl. L4), Oesophagostomum columbianum (incl. L4), Oesophagostomum venulosum, Nematodirus filicollis (incl. L4), Chabertia ovina (incl. L4), Trichuris ovis.
- Lungworms: Dictyocaulus filaria (incl. L4), Protostrongylus rufescens.
- Nasal bots: Oestrus ovis.
- Mange mites: Psoroptes ovis. Two injections with a seven-day interval are required to treat clinical signs of scab and to eliminate mites.
*Can be slightly different in some countries: read the product label!
- Cattle: 200 mcg/kg bw, equivalent to 1 ml/50 kg (=110 lb) bw
- Sheep: 200 mcg/kg bw, equivalent to 0.5 ml/25 kg (=55 lb) bw
- Swine: 300 mcg/kg bw, equivalent to 1 ml/33 kg (=75 lb) bw
- LD50 (acute oral) in rats: 5000 mg/kg (estimate, source: MSDS)
- LD50 (acute dermal) in rats: >66000 mg/kg (estimate, source: MSDS)
- Estimated hazard class according to the WHO: not applicable for veterinary medicines
Suspected poisoning? Read the articles on ivermectin safety in this site.
Withholding periods (=withdrawal times) for meat & milk (country-specific differences may apply: read the product label)
- Cattle: USA, Canada: 35 days (CA); UK: 49 days; Australia: 28 days.
- Sheep: Canada: 35 days; UK: 42 days
- Swine: USA, Canada: 18 days: UK: 28 days
Not approved for use on dairy animals producing milk for human consumption.
Non-lactating dairy cattle: treat at least 2 months prior to calving.
WARNING !!!: Never use on humans, dogs or cats
Risk of resistance? YES, in gastrointestinal roundworms in sheep (very high), goats (very high) and cattle (high) particularly in:
- Sheep & goats: Haemonchus spp, Ostertagia spp /Teladorsagia spp, Trichostrongylus spp, Nematodirus spp, Chabertia ovina
- Cattle: Cooperia spp, Haemonchus spp, Oesophagostomum spp, Ostertagia spp, Trichuris spp
Resistance of gastrointestinal roundworms to ivermectin in sheep, goats and cattle has been reported almost worldwide, including the USA, UK, Australia and New Zealand. Based on the very abundant and frequent use of ivermectin and other macrocyclic lactones (with cross-resistance to ivermectin) in livestock it must be assumed that resistance of these roundworms to this chemical class will continue spreading and strengthening in the future.
This means that if this product does not achieve the expected efficacy against the mentioned parasites, it may be due to resistance and not to incorrect use, which is usually the most frequent cause of product failure.
- Benzimidazoles, e.g. albendazole, febantel, fenbendazole, oxfendazole, etc. Similar or even worse resistance problems than macrocyclic lactones
- Imidazothiazoles, mainly levamisole. etc. Similar or even worse resistance problems than macrocyclic lactones
- Monepantel, only for sheep & goats in some countries (e.g. EU, Australia, New Zealand)
- Nitroxinil (limited spectrum of activity)
- Tetrahydropyrimidines, e.g. morantel, pyrantel (limited spectrum of activity)
- Salicylanilides, e.g. closantel (limited spectrum of activity)
These alternative products may not be available in all countries, or may not be available as injectables.
Are the active ingredients of this product ORIGINAL* or GENERICS**?
*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.
COUNTRIES where this product is marketed (maybe under another TM): Worldwide, including the US, Canada, the EU, Australia, etc., sometimes under the trade name IVOMEC CLASSIC.
GENERIC BRANDS available? YES, worldwide by the hundreds.
Click here to learn more about GENERIC vs. ORIGINAL drugs.
For an overview on the most used antiparasitic injectable brands for livestock click here.
IVOMEC 1% injectable is the mythical first brand of ivermectin launched by MS&D (later MERIAL) in the early 1980's. Ivermectin was the first macrocyclic lactone introduced in the market. It was a milestone and a tremendous progress that revolutionized the control of veterinary parasites in livestock. Nowadays there are thousands of brands with generic ivermectin worldwide.
Whereas IVOMEC 1% injectable is approved for use on cattle worldwide, approval for use on sheep, swine, goats and other minor species (e.g. bisons, deer, etc.) depends on the country. These differences are most likely due to MERIAL's marketing strategies in the different countries (e.g. market segmentation, local product portfolio, etc.) and not to regulatory hurdles.
All 1% ivermectin injectables used on cattle at the recommended dose of 200 mcg/kg offer a rather poor control of cattle ticks Boophilus (=Rhipicephalus) microplus, usually insufficient for most producers.
The different withholding periods in various countries illustrate the fact that unfortunately, national regulatory authorities often draw different conclusions from the same scientific evidence. This has been always so and there are no indications that things will improve in the near future.
Being one of the best antiparasitics ever developed, ivermectin does not control all parasites of livestock. Unfortunately advertising and even the label of some generic formulations in less developed countries often include unsubstantiated claims. To help preventing confusion and misuse it is useful to know that whatever ivermectin 1% injectable used at the recommended dose DOES NOT CONTROL:
- Ticks (e.g. Amblyomma spp, Rhipicephalus spp, Dermacentor spp, Haemaphysalis spp, Hyalomma spp, Ixodes spp, etc.)
- Flies (e.g. horn flies, houseflies, stable flies, black flies, horse flies, etc.)
- Fleas (e.g. Ctenocephalides spp)
- Blowfly strike of sheep
- Tapeworms (e.g. Moniezia spp spp)
- Flukes (e.g. liver fluke Fasciola hepatica)
This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics.
Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.
In case of doubt contact the manufacturer or a veterinary professional.