Brand: TELMIN ® 2G GRANULES

Company: ELANCO

FORMULATION: «feed additives» to be added to feed immediately before administration

ACTIVE INGREDIENT(S): mebendazole 100 mg/g (equivalent to 10%)

CHEMICAL CLASS of the active ingredient(s): benzimidazole

INDICATIONS

HORSES & DONKEYS

PARASITES CONTROLLED* (spectrum of activity)

* Country-specific differences may apply: read the product label.

• Large strongyles: Strongylus vulgaris, Strongylus edentatus, Strongylus equinus, Triodontophorus spp.
• Small strongyles: Cyathostomes
• Stomach worms: Trichostrongylus axei
• Ascarids: Parascaris equorum
• Pinworms: Oxyuris equi, Probstmayria vivipara
• Lungworms: Dictyocaulus arnfieldi

RECOMMENDED DOSE*

*Can be slightly different in some countries: read the product label!

• Horses: The dose rate is 5–10 mg mebendazole per kg bodyweight orally. Repeat this dose every 6 weeks. Horses 200-400 kg 1 sachet; Horses 401-800 kg 2 sachets
• Donkeys: For the treatment of Dictyocaulus arnfieldi give orally at the rate of 15–20 mg mebendazole per kg bodyweight daily for 5 consecutive days. Donkey 151-200 kg 1½ sachets daily for 5 days; Donkey 201-250 kg 2 sachets daily for 5 days; Donkey 251-300 kg 2½ sachetsdaily for 5 days; Donkey 301-350 kg 3 sachets daily for 5 days-

SAFETY

• LD50 (acute oral) in rats: >5000 mg/kg (estimate calculated according to the WHO based on the LD50)
• Estimated hazard class according to the WHO: not applicable for veterinary medicines
  

Suspected poisoning? Read the articles on mebendazole safety in this site.

Withholding periods (=withdrawal times) for meat & milk (country-specific differences may apply: read the product label)

• MEAT & OFFAL: Not to be used in horses intended for human consumption.Treated horses may never be slaughtered for human consumption. The horse must have been declared as not intended for human consumption under national horse passport legislation
• MILK: Do not use in mares producing milk for human consumption.

WARNING !!!: Never use on humans, dogs or cats

You may be interested in the following articles in this site dealing with the general safety of veterinary products:

• Safety for humans
• Safety for domestic animals
• Safety for the environment
• Hazard classifications of pesticides

RESISTANCE PREVENTION

Risk of resistance? YES

• Small strongyles (cyathostomes). Resistance of small strongyles to benzimidazoles is widespread and frequent e.g. in the USA, UK and Europe, Argentina, Chile, Uruguay, etc. 
• Parascaris equorum: Cases of tolerance to benzimidazoles have been also reported (e.g. in the USA). Resistance to macrocyclic lactones (e.g. ivermectin, moxidectin) has been reported in the USA, UK and Australia.

This means that if this product does not achieve the expected efficacy against the mentioned parasites, it may be due to resistance and not to incorrect use, which is usually the most frequent cause of product failure.

Alternative chemical classes/active ingredients to prevent resistance of gastrointestinal roundworms through product rotation:

• Imidazothiazoles, mainly levamisole. Not approved for use in horses in many countries.
• Macrocyclic lactones: mainly ivermectin, moxidectin. But tolerance or resistance to these compounds have also been reported in Europe (e.g. in the UK, Germany, Italy), the USA, and Brazil.
• Tetrahydropyrimidines, mainly pyrantel (limited spectrum of activity), but resistance cases have also been reported (e.g. Australia, USA, Brazil, Japan).

These alternative products may not be available in all countries, or may not be available as oral pastes or gels.

Learn more about resistance and how it develops.

MARKETING

Are the active ingredients of this product ORIGINAL* or GENERICS**?

• GENERICS
  

*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.

COUNTRIES where this product is marketed (maybe under another TM): UK and other EU countries.
GENERIC BRANDS available? YES, in some countries, but not too many.

Click here to learn more about GENERIC vs. ORIGINAL drugs.

Click here for an overview on the most used antiparasitic feed additives and medicated feeds for livestock and horses.

COMMENTS

This product is a classic feed additive dewormer for horses from ELANCO with generic mebendazole.

Mebendazole is a veteran benzimidazole introduced in the 1970s (by JANSSEN) that is moderately used in horses and pets, but rather scarcely in ruminants. It is also used in human medicines. It is a broad-spectrum anthelmintic effective against roundworms in the gut and the lungs, but not against those in the skin. It is also ineffective against gastric bots (Gasterophilus spp) or whatever external parasites. At the recommended dose it is also ineffective against horse tapeworms (Anoplocephala spp).

For an overview and a list of the most used antiparasitic feed additives for livestock (incuding horses) click here.

DISCLAIMER

This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics. 

Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.

In case of doubt contact the manufacturer or a veterinary professional.