Brand: EPRINEX ® MULTI 5mg/mL Pour-on
Company: BOEHRINGER INGELHEIM (MERIAL)
INDICATIONS: CATTLE (Beef & Dairy), SHEEP & GOATS
PARASITES CONTROLLED* (spectrum of activity)
* Country-specific differences may apply: read the product label.
- Gastrointestinal roundworms (adults and L4 larvae): Ostertagia ostertagi (incl. inhibited larvae), Ostertagia lyrata (adults only), Haemonchus placei, Trichostrongylus axei, Trichostrongylus colubriformis, Trichostrongylus longispicularis (adults only), Bunostomum phlebotomum, Cooperia onchophora, Cooperia pectinata, Cooperia punctata, Cooperia surnabada, Nematodirus helvetianus, Oesophagostomum radiatum, Strongyloides papillosus (adults only), Trichuris spp (adults only).
- Lungworms (adults and L4 larvae): Dictyocaulus viviparus.
- Cattle grubs (warbles, parasitic stages): Hypoderma bovis, Hypoderma lineatum.
- Sucking & biting lice: Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus, Bovicola (Damalinia) bovis
- Mites (scabies): Sarcoptes scabiei var. bovis, Chorioptes bovis
- Horn flies: Haematobia irritans irritans
- Residual effect (significant country differences: read the product label!):
- Gastrointestinal roundworms (adults): Teladorsagia circumcincta (pinnata/trifurcata), Haemonchus contortus, Trichostrongylus axei, Trichostrongylus colubriformis, Nematodirus battus, Cooperia curticei, Chabertia ovina, Oesophagostomum venulosum.
- Lungworms (adults): Dictyocaulus filaria.
- Gastrointestinal roundworms (adults): Teladorsagia circumcincta (pinnata/trifurcata), Haemonchus contortus, Trichostrongylus axei, Trichostrongylus colubriformis, Nematodirus battus, Cooperia curticei, Oesophagostomum venulosum.
- Lungworms (adults): Dictyocaulus filaria.
*Can be slightly different in some countries: read the product label!
- Cattle: 0.5 mg eprinomectin per kg bw, corresponding to the recommended dose rate of 1 ml product per 10 kg bw.
- Sheep and goats: 1.0 mg eprinomectin per kg bw, corresponding to the recommended dose rate of 2 ml product per 10 kg bodyweight.
Read the complete product label carefully and ensure thorough accomplishment of all the use instructions.
- LD50 (acute oral) in rats: >5000 mg/kg (estimate according to the LD50 of the active ingredient)
- Estimated hazard class according to the WHO: not applicable for veterinary medicines
Suspected poisoning? Read the article on eprinomectin safety in this site.
Withholding periods (=withdrawal times) for meat & milk (country-specific differences may apply: read the product label)
- Meat & offal:
- Cattle: Ireland 15 days
- Sheep. Ireland 2 days
- Goats: Ireland 1 day
- Milk for human consumption:
- Cattle, sheep & goats: Ireland zero hours
WARNING !!!: Never use on humans, dogs and cats
You may be interested in the following articles in this site dealing with the general safety of veterinary products:
- Safety for humans
- Safety for domestic animals
- Safety for the environment
- Hazard classifications of pesticides
Risk of resistance? YES, reported for ivermectin in gastrointestinal roundworms in sheep goats & cattle in several countries, particularly in the following worm species: Haemonchus spp, Cooperia spp, Ostertagia spp,Trichostrongylus spp, Nematodirus spp and Chabertia ovina, whereby cross-resistance between eprinomectin and ivermectin must be assumed.
Based on the very abundant and frequent use of ivermectin and other macrocyclic lactones (with cross-resistance to ivermectin) in livestock it must be assumed that resistance of these roundworms to this chemical class will continue spreading and strengthening in the future.
This means that if this product does not achieve the expected efficacy against the mentioned parasites, it may be due to resistance and not to incorrect use, which is usually the most frequent cause of product failure.
- Benzimidazoles, e.g. albendazole, febantel, fenbendazole, oxfendazole, etc. Similar or even worse resistance problems than ivermectin
- Imidazothiazoles, mainly levamisole. etc. Similar or even worse resistance problems than ivermectin
- Levamisole.Resistance to levamisole has been reported in most countries, but is usually less strong and frequent than to macrocyclic lactones.
- Monepantel: available only only for sheep & goats in some countries (e.g. Australia, EU, New Zealand). First cases of resistance reported in New Zealand in 2013.
- Nitroxinil (limited spectrum of activity)
- Tetrahydropyrimidines, e.g. morantel, pyrantel (limited spectrum of activity)
- Salicylanilides, e.g. closantel (limited spectrum of activity)
These alternative products may not be available in all countries, or may not be available as pour-ons.
Are the active ingredients of this product ORIGINAL* or GENERICS**?
*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.
COUNTRIES where this brand/product is marketed (maybe under another TM): UK, Ireland and other EU countries.
GENERIC BRANDS available? YES, but rather few and not in most countries
Click here to learn more about GENERIC vs. ORIGINAL drugs.
For an overview on the most used antiparasitic pour-on brands click here.
EPRINEX MULTI Pour-on for cattle, sheep & goats is basically the same as IVOMEC EPRINEX for cattle but containing also 0.06 mg/ml vitamin E and approved also for use on sheep and goats.
Eprinomectin was one of the last macrocyclic lactones introduced in the 1990s (by MERIAL). It was the first macrocyclic lactone approved for use on dairy cows because it does not leave significant residues in milk, in contrast with all ivermectin-based products. Nowadays other macrocyclic lactones (e.g. doramectin, moxidectin) have been approved for use on dairy cows in some countries. The spectrum of activity of eprinomectin is similar to that of ivermectin and other macrocyclic lactones: mainly roundworms, lice and mites and, delivered as a pour-on, also some fly and tick species. It is ineffective against tapeworms and flukes. Eprinomectin is moderately used in cattle but not in other livestock. It is marginally used in cats, but not in dogs. It is not used in agriculture.
And all pour-ons, including this one have general disadvantages compared with injectables. In several scientific studies it has been shown that ivermectin administered as a pour-on is not "automatically" absorbed through the skin. Licking (self licking or licking of other treated animals) may account for >50% of the total intake, compared with only about 10% absorbed directly through the skin. This is the reason why a dose of 500 mcg/kg bw is needed after pour-on treatment, compared with only 200 mcg/kg bw after injection. And it has been also shown that intake of topically administered active ingredient in some cattle may be twice as high as in other ones, all treated at the same rate. The reason is that individual cattle show a different licking behavior. An important practical consequence is that the quantity that is finally ingested and is therefore available for the control of gastrointestinal worms depends on the licking behavior of the treated animals. "High lickers" can be overdosed, whereas "low lickers" can be underdosed. And chronic underdosing of animals in a herd may enhance development of resistance to ivermectin and other macrocyclic lactone in gastrointestinal roundworms.
To our knowledge similar studies have not been carried out with the eprinomectin pour-ons, but it must be assumed that the licking-behavior of cattle affects intake of eprinomectin in a comparable way. A similar effect of the licking behavior on the intake of active ingredient after pour-on administration has also been shown for fluazuron, a tick development inhibitor.
Absorption through the skin is also negatively affected by the thickness of the skin and the hair coat, by dust and mud on the coat, by product lost on fences and yards, etc, factors that don't play a role after injection.
In contrast with the injectable formulations, the pour-on formulations should not be administered to wet animals, and rain shortly before (up to 6 hours) or after administration can cause product run-off and thus under-dosing. The pour-on shouldn't be administered by strong winds that may blow away part of the product and/or contaminate the workers.
For all these reasons efficacy after pour-on administration is usually less reliable than after injection.
Being an excellent antiparasitic, comparable to ivermectin, eprinomectin does not control all parasites of livestock. Unfortunately advertising and even the label of some generic formulations in less developed countries often include unsubstantiated claims. To help preventing confusion and misuse it is useful to know that whatever eprinomectin 0.5% pour-on formulation (without additional active ingredients) used at the recommended dose DOES NOT CONTROL:
- Most ticks (e.g. Amblyomma spp, Rhipicephalus spp, Dermacentor spp, Haemaphysalis spp, Hyalomma spp, Ixodes spp, etc.)
- Flies other than horn flies (e.g. houseflies, stable flies, black flies, horse flies, etc.)
- Fleas (e.g. Ctenocephalides spp)
- Tapeworms (e.g. Moniezia spp)
- Flukes (e.g. liver fluke Fasciola hepatica)
Click here for general information on good practices for the prevention and control of gastrointestinal worms in livestock.
This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics.
Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.
In case of doubt contact the manufacturer or a veterinary professional