Brand: RIDAFLUKE ® 30 mg/mL Oral Suspension
INDICATIONS: CATTLE & SHEEP
PARASITES CONTROLLED (spectrum of activity)
For the treatment of:
- fascioliasis in cattle and sheep Fasciola hepatica infections.
- In sheep, it is effective against mature liverfluke and 83% effective against 4 week-old immature fluke.
- In cattle, it is effective against mature fluke.
- For sheep, the recommended dose is 7.5 mg rafoxanide per kg bw (equivalent to 3 mL product per 8 kg bw).
- For cattle, the recommended dose is 11.25 mg rafoxanide per kg bw (equivalent to 15 mL product per 40 kg bw).
Read the product label for specific details on dosage.
* Country-specific differences may apply: read the product label.
- LD50 (acute oral) in rats: >2000 mg/kg (for the a.i.)
- LD50 (acute dermal) in rats: n.a.
Suspected poisoning? Read the article on rafoxanide safety in this site.
Withholding periods (=withdrawal times) for meat & milk (country-specific differences may apply: read the product label)
- Cattle Ireland 60 days
- Sheep Ireland 60 days
- Milk: Ireland
- Cattle: Not authorised for use in cattle producing milk for human consumption including during the dry period. Do not use during the last trimester of pregnancy in heifers which are intended to produce milk for human consumption.
- Sheep: Not authorized for use in ewes producing milk for human consumption including during the dry period. Do not use within 1 year prior to the first lambing in ewes intended to produce milk for human consumption.
WARNING !!!: Never use on humans, dogs or cats
You may be interested in the following articles in this site dealing with the general safety of veterinary products:
- Safety for humans
- Safety for domestic animals
- Safety for the environment
- Hazard classifications of pesticides
Risk of resistance: LOW
There are a few reports on resistance of liver flukes to rafoxanide, but it does not seem to be a widespread problem in most countries. This means that if this product does not achieve the expected efficacy against the mentioned parasites, it is probably not due to resistance but to incorrect use, which is usually the most frequent cause of product failure.
However, prolonged uninterrupted use of this and other flukicides may lead to resistance development.
- Benzimidazoles (e.g. albendazole,triclabendazole). Resistance not rare in numerous countries.
- Closantel (salicylanilide): effective only against ≥8 weeks old liver flukes.
- Clorsulon: effective only against ≥8 weeks old liver flukes.
- Nitroxinil: effective only against ≥8 (sheep) or ≥7 (cattle) weeks old liver flukes.
- Oxyclozanide (salicylanilide): effective only against ≥12 (sheep) or ≥10 (cattle) weeks old liver flukes.
These alternative products may not be available in all countries, or may not be available as drenches, or may not be effective against all the concerned parasites.
It is highly recommended to periodically check the resistance status of each property performing appropriate tests (e.g. fecal egg counts) under supervision of a veterinary doctor. Such tests are now routinely available for most producers in developed countries.
Are the active ingredients of this product ORIGINAL* or GENERICS**?
*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.
COUNTRIES where this brand/product is marketed: Ireland
GENERIC BRANDS available? Yes, but rather few in most countries, if at all.
Click here to learn more about GENERIC vs. ORIGINAL drugs.
For an overview on the most used antiparasitic drench brands click here.
RIDAFLUKE 30 mg/mL Oral Suspension from CHANELLE is a classic flukicide drench with generic rafoxanide.
Rafoxanide is a narrow-spectrum salicylanilide introduced in the 1970s (by MS&D AgVet, now Merial). It is effective against liver flukes (Fasciola hepatica mature and immature over 8 weeks of age) and a few gastrointestinal nematodes such as Haemonchus spp and Bunostomum spp. It is not used in pets or horses, and nowadays usage in livestock is very scarce because other flukicides (e.g. closantel, triclabendazole, oxyclozanide) are often preferred in combinations. It is not used in agriculture.
In ruminants, reducing the amount of feed slows down the exit flow of the rumen and prolongs the time during which the active ingredient remains there and is absorbed. Consequently it is advisable to reduce the access of animals to feed (especially to fresh pasture, not to water) 24 hours before administration. For the same reason, it is better to keep the animals away from food for about 6 hours after drenching. However sick or weak animals should not be kept away from food and fasting animals should have access to water. In cattle, a fiber-rich diet also increases the bioavailability of fenbendazole.
Thoroughly shaking suspensions before use is crucial for efficacy. If the active ingredient remains in the sediment, a few animals may get most of the active ingredient and will be overdosed, and the large majority will get almost only solvents and will be underdosed.
This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics.
Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.
In case of doubt contact the manufacturer or a veterinary professional.