Brand: GENESIS ® HI-Mineral

Company: BOEHRINGER INGELHEIM (MERIAL)


DELIVERY FORM: «drench» for oral administration.

ACTIVE INGREDIENT(S): abamectin 1.0 mg/mL (equivalent to 0.1%).

  • contains also minerals (Cobalt, Seleniun, Cooper, Zinc, Iodine), not effective as anthelmintics.

CHEMICAL CLASS of the active ingredient(s): macrocyclic lactone


INDICATIONS: SHEEP


PARASITES CONTROLLED* (spectrum of activity)

* Country differences may apply: read the product label!


RECOMMENDED DOSE

  • Sheep: 1 ml product/5 kg bw (equivalent to 0.2 mg of abamectin/kg)

Read the product label for further details on dosing.


SAFETY

  • LD50 (acute oral) in rats: a.i. 10 mg/kg
  • LD50 (acute dermal) in rats: abamectin: a.i. 330 mg/kg

Suspected poisoningRead the article on abamectin safety in this site.

Withholding periods (=withdrawal times) in days for meat & milk (country-specific differences may apply: read the product label)

  • Meat: New Zealand 14 days
  • Milk for human consumption: New Zealand 35 days


RESISTANCE PREVENTION

Risk of resistance? YES, resistance of gastrointestinal roundworms to macrocyclic lactones (incl. abamectin) in ruminants is a very serious and increasing problem worldwide, particularly in sheep and goats. The most affected worm species are: Haemonchus spp, Ostertagia spp /Teladorsagia spp, Trichostrongylus spp, Nematodirus spp, Chabertia ovina.

This means that if this product does not achieve the expected efficacy against the mentioned parasites, it can be due to resistance and not to incorrect use, which is usually the most frequent cause of product failure.

Alternative chemical classes/active ingredients to prevent resistance of gastrointestinal roundworms through product rotation:

These alternative products may not be available in all countries, or may not be available as drenches, or may not be effective against all the concerned parasites.

It is highly recommended to periodically check the resistance status of each property performing appropriate tests (e.g. fecal egg counts) under supervision of a veterinary doctor. Such tests are now routinely available for most producers in developed countries.

Learn more about resistance and how it develops.


MARKETING

Are the active ingredients of this product ORIGINAL* or GENERICS**?

  • GENERICS

*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.

COUNTRIES where this brand/product is marketed: New Zealand
GENERIC BRANDS available? Yes, abundant in Australia and New Zealand, not in the USA or Europe.

Click here to learn more about GENERIC vs. ORIGINAL drugs.

For an overview on the most used drench brands for livestock click here.


COMMENTS

GENESIS HI-MINERAL Drench for Sheep is a brand with generic abamectin, in this case complemented with various minerals (Cobalt, Seleniun, Cooper, Zinc, Iodine) that have no anthelmintic efficacy whatsoever.

Abamectin, one of the first macrocyclic lactones developed, was introduced already in the 1980s (by MSD AGVET). As all macrocyclic lactones, abamectin is an endectocide, i.e. it is simultaneously effective against some external parasites and against internal parasites (mainly roundworms). As for other macrocyclic lactones, abamectin has no efficacy whatsoever against tapeworms and flukes. Abamectin is considered as the "cheap" ivermectin, with a similar spectrum of efficacy but less potent and slightly more toxic. It is abundantly used in ruminants, much less in pig, poultry and pets. Abamectin is also used in agricultural and hygiene pesticides worldwide. Interestingly abamectin is widely used on livestock in Australia and New Zealand but insignificantly in the EU, the USA and Canada.

There are also numerous brands with mixtures of abamectin with other active ingredients, both as drenches and as injectables. In some countries slow-release capsules for oral administration to sheep that ensure a long period of protection against re-infestation are also available.

In ruminants, reducing the amount of feed slows down the exit flow of the rumen and prolongs the time during which the active ingredient remains there and is absorbed. Consequently it is advisable to reduce the access of animals to feed (especially to fresh pasture, not to water) 24 hours before administration. For the same reason, it is better to keep the animals away from food for about 6 hours after drenching. However sick or weak animals should not be kept away from food and fasting animals should have access to water.

Click here for general information on good practices for the prevention and control of gastrointestinal worms in livestock.


DISCLAIMER

This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics. 

Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.

In case of doubt contact the manufacturer or a veterinary professional.