CYDECTIN S Oral Drench for SHEEP - ZOETIS - moxidectin 0.1% - macrocyclic lactone

Brand: CYDECTIN ® S

Company: ZOETIS

DELIVERY FORM: «drench» for oral administration.

ACTIVE INGREDIENT(S): moxidectin 1 mg/mL (equivalent to 0.1%).

  • + 0.5 mg/mL Selenium without anthelmintic efficacy.

CHEMICAL CLASS of the active ingredient(s): macrocyclic lactone

INDICATIONS: SHEEP

PARASITES CONTROLLED* (spectrum of activity)

* Country-specific differences may apply: read the product label.

RECOMMENDED DOSE*

* Country-specific differences may apply: read the product label.

  • Sheep: 1 mL product/11 lb bw = 1 ml product/5 kg bw (equivalent to 0.2 mg of moxidectin/kg)
  • Read the product label for further details on dosing.

SAFETY

  • LD50 (acute oral) in rats: 106 mg/kg (for the a.i. moxidectin)
  • Estimated hazard class according to the WHO: not applicable for veterinary medicines

Suspected poisoning? Read the article on moxidectin safety in this site.

Withholding periods (=withdrawal times) in days for meat & milk (country-specific differences may apply: read the product label)

  • Meat: New Zealand: 10 days
  • Milk for human consumption: New Zealand: 84 hours (7 milkings).

WARNING !!!: Never use on humans, dogs and cats

You may be interested in the following articles in this site dealing with the general safety of veterinary products:

RESISTANCE PREVENTION

Risk of resistance? YES, resistance of gastrointestinal roundworms to macrocyclic lactones (incl. ivermectin) in ruminants is a very serious and increasing problem worldwide, particularly in sheep and goats. The most affected worm species are: Haemonchus spp, Ostertagia spp /Teladorsagia spp, Trichostrongylus spp, Nematodirus spp, Chabertia ovina.

Resistance of gastrointestinal roundworms to macrocyclic lactones in sheep, goats has been reported in numerous countries. Most cases have been reported for ivermectin, and moxidectin often works well against ivermectin-resistant worms initially. But if moxidectin use continues, gastrointestinal roundworms will become resistant to it rather quickly. Based on the very abundant and frequent use of ivermectin and other macrocyclic lactones in livestock (with more-or-less cross-resistance to ivermectin) it must be assumed that resistance of gastrointestinal roundworms to this chemical class will continue spreading and strengthening in the future.

Alternative chemical classes/active ingredients to prevent resistance of gastrointestinal roundworms through product rotation:

These alternative products may not be available in all countries, or may not be available as drenches, or may not be effective against all the concerned parasites.

It is highly recommended to periodically check the resistance status of each property performing appropriate tests (e.g. fecal egg counts) under supervision of a veterinary doctor. Such tests are now routinely available for most producers in developed countries.

Learn more about resistance and how it develops.

MARKETING

Are the active ingredients of this product ORIGINAL* or GENERICS**?

  • GENERICS

*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.

COUNTRIES where this brand/product is marketed: NEW ZEALAND. Marketing of the CYDECTIN Oral Drench (and other moxidectin formulations) is quite special. It is marketed by ZOETIS in the UK (and other EU countries) and New Zealand; by BOEHRINGER INGELHEIM in the USA; by VIRBAC in Australia, etc. Moxidectin, the a.i. of CYDECTIN was introduced by AMERICAN CYANAMID in the 1990s. After various subsequent acquisitions it landed in FORT DODGE, a part of WYETH, which was acquired by PFIZER. But PFIZER Animal Health already had its own livestock ML (doramectin), and two livestock MLs were obviously redundant. After its spin-off from PFIZER, ZOETIS has sold or licensed out CYDECTIN to several companies. The current situation may change in the future.
GENERIC BRANDS available? YES, many brands in some countries (e.g. Australia, New Zealand), rather few, if at all, in other countries (e.g. the EU, USA).

Click here to learn more about GENERIC vs. ORIGINAL drugs.

For an overview on the most used drench brands for livestock click here.

COMMENTS

CYDECTIN S oral drench for sheep from ZOETIS with 0.1% moxidectin is basically the same as CYDECTIN complemented with Selenium.

Moxidectin is a macrocyclic lactone introduced in the 1990s (by AMERICAN CYANAMID). It is moderately used in livestock and pets, but not in agriculture. Its spectrum of activity is similar to the one of  ivermectin, i.e. basically roundworms and certain external parasites (mites, lice, etc.). As all other macrocyclic lactones moxidectin is not effective against tapeworms and flukes. Moxidectin is generally considered as more potent than ivermectin against gastrointestinal nematodes of livestock, particularly in sheep and goats, and against a few other livestock pests (e.g. sheep scab, cattle ticks, etc.). It is also less toxic than ivermectin, which makes it possible to use it at higher rates, particularly in long-acting formulations. Moxidectin is moderately used in livestock and horses, but rather scarcely in pets. It is not used in agriculture.

In some countries there are also antiparasitic brands containing mixtures of moxidectin with other active ingredients, and/or with mineral salts (e.g. Selenium).

In ruminants, reducing the amount of feed slows down the exit flow of the rumen and prolongs the time during which the active ingredient remains there and is absorbed. Consequently it is advisable to reduce the access of animals to feed (especially to fresh pasture, not to water) 24 hours before administration. For the same reason, it is better to keep the animals away from food for about 6 hours after drenching. However sick or weak animals should not be kept away from food and fasting animals should have access to water.

Click here for general information on good practices for the prevention and control of gastrointestinal worms in livestock.

DISCLAIMER

This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics. 

Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.

In case of doubt contact the manufacturer or a veterinary professional.

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