Triclabendazole is a narrow-spectrum benzimidazole with high flukicidal efficacy. It is not effective against roundworms, tapeworms or external parasites.

Triclabendazole is certainly the most used flukicide in livestock. It is available mainly as a drench, but also as a topical pour-on (mainly for cattle), often mixed with other anthelmintics with nematicidal efficacy (e.g. ivermectin, levamisole, etc.). It is not used in swine, poultry, or pets, simply because flukes are usually not an issue for these animals. It is not used in crop protection either.

Unfortunately, resistance of the liver fluke (Fasciola hepatica) to triclabendazole and other benzimidazoles is already quite frequent in sheep and goats in numerous countries, less in cattle but increasing.

All benzimidazoles have almost no residual effect, i.e. they kill the parasites during a few hours after treatment but offer no significant protection against re-infestation.

The table below indicates some usual dosing recommendations for triclabendazole issued by manufacturers or documented in the scientific literature. They may not be approved in some countries.

Dosing recommendations for TRICLABENDAZOLE
Delivery Parasites Dose (against triclabendazole-susceptible parasites)
Oral Fasciola hepatica, Fasciola gigantica 12 mg/kg
Topical Fasciola hepatica 30 mg/kg
Oral Fasciola hepatica, Fasciola gigantica 10 mg/kg
Oral Fasciola hepatica 10-12 mg-kg
Oral Fasciola hepatica, Fasciola gigantica 10-15 mg-kg
Oral Fascioloides magna 10 mg/kg in the feed during 6-7 days

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Dosing recommendations for antiparasitics depend on national regulations. National regulatory authorities determine whether a product is approved for a given indication, i.e. use on a particular host at a specific dose and against a specific parasite. Check the labels of the products available in your country for specific information on approved indications.

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