FORMULATION: «spot-on» for topical administration administration


CHEMICAL CLASS of the active ingredient(s):


PARASITES CONTROLLED* (spectrum of activity):

* Can be slightly different in some countries: read the product label!


EU and other countries: min. 3.0 mg/kg emodepside and 12.0 mg/kg praziquantel

Available in tablets of different sizes:

  • Pipettes for small cats: 0.35 mL containing 7.5 mg emodepside (=2.14%) and 30 mg praziquantel (=8.56%)
  • Pipettes for medium cats: 0.70 mL containing 15 mg emodepside (=2.14%) and 60 mg praziquantel (=8.56%)
  • Pipettes for large cats: 1.12 mL containing 24 mg emodepside (=2.14%) and 96 mg praziquantel (=8.56%)

Recommended dosage table:

  • Cats 0.5 to 2.5 kg 1.1 to 5.5 lbs. bw: one 0.35 ml pipette equivalent to 15.0 - 3.0 mg/kg emodepside and 60.0 - 12.0 mg/kg praziquantel
  • Dogs >2.5 to 5.0 kg >5.5 to 11 lbs. bw: one 0.70 ml pipette equivalent to 6.0 - 3.0 mg/kg emodepside and 24.0 - 12.0 mg/kg praziquantel
  • Dogs >5.0 to 8.0 kg ≈ >11 to 17.6 lbs. bw: one 1.12 ml pipette equivalent to 4.8 - 3.0 mg/kg emodepside and 19.2 - 12.0 mg/kg praziquantel

* Can be slightly different in some countries: read the product label!


  • LD50 (acute oral) in rats: n.a. for the spot-on formulation. 500 to 1000 mg/kg for emodepside a.i., and 2000 - 3000 mg/kg for praziquantel a.i.
  • Estimated Hazard Class according to the WHO: not applicable for veterinary medicines

Suspected poisoning? Read the articles on emodepside safety and/or on praziquantel safety in this site.

You may be interested in the following articles in this site dealing with the general safety of veterinary products:


Risk of resistance development? NO

There are no reports of resistance or tolerance of roundworms or hookworms to emodepside.

There are no reports on resistance of pet tapeworms to praziquantel.

Learn more about resistance and how it develops.


Are the active ingredients of this product ORIGINAL* or GENERICS**?

  • Emodepside: GENERIC (introduced in the 1990s)
  • Praziquantel: GENERIC (introduced in the 1970s)

*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.

COUNTRIES where this product is marketed: EU, Australia and other countries.

Click here to learn more about GENERIC vs. ORIGINAL drugs.


PROFENDER is one of BAYER's original wormers for cats in the form of a spot-on containing emodepside and praziquantel.

Emodepside is a broad-spectrum nematicide belonging to the chemical class of the depsipeptides introduced in the 1990s (by BAYER). It is used only on pets, not in livestock or agriculture. It is effective against the most important parasitic worms of cats, such as roundworms (Toxocara cati) and hookworms (Ancylostoma tubaeforme). Emodepside is not effective against tapeworms.

Praziquantel is a veteran isoquinoline anthelmintic introduced in the 1970s (by BAYER). It is effective against most tapeworms that infect cats (e.g. Dipylidium caninum, Taenia spp) but has no efficacy whatsoever against roundworms or hookworms. There are hundreds of antiparasitic brands for pets containing praziquantel, but rather few as a spot-on. 

PROFENDER is also available for dogs in the form of a tablets for oral administration.

For an overview and a list of the most popular pet wormers click here.


This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics. 

Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.

In case of doubt contact the manufacturer or a veterinary professional.