Brand: LEVACIDE Pour-on for Cattle
FORMULATION: «pour-on» for topical administration. To be applied along the flattest part of the backline.
ACTIVE INGREDIENT(S): levamisole: 200 g/L (= 20%)
CHEMICAL CLASS of the active ingredient(s): imidazothiazole
PARASITES CONTROLLED (spectrum of activity)
- Gastrointestinal roundworms (adults and L4 larvae): Haemonchus placei, Ostertagia ostertagi (excl. inhibited larvae), Trichostrongylus spp, Cooperia spp, Oesophagostomum spp, Bunostomum phlebotomum, Nematodirus spp.
- Lungworms: Dictyocaulus viviparus.
- Cattle: 2.5 ml product/50 kg bw, equivalent to 10 mg/kg bw
- LD50 (acute oral) in rats: for the a.i. 180 mg/kg.
- LD50 (acute dermal) in rats: n.a.
- Estimated hazard class according to the WHO: not applicable for veterinary medicines
Suspected poisoning? Read the article on levamisole safety in this site.
Withholding periods (=withdrawal times) for meat & milk (country-specific differences may apply: read the product label)
- Meat: UK 28 days
- Milk for human consumption: Do not use in animals producing milk for human consumption.
WARNING !!!: Never use on humans, dogs and cats
You may be interested in the following articles in this site dealing with the general safety of veterinary products:
- Safety for humans
- Safety for domestic animals
- Safety for the environment
- Hazard classifications of pesticides
Risk of resistance? YES, reported in gastrointestinal roundworms in cattle in several countries particularly in the following worm species: Cooperia spp and Ostertagia spp.
Based on the very abundant and frequent use of levamisole in livestock it must be assumed that resistance of these roundworms to this chemical class will continue spreading and strengthening in the future.
This means that if this product does not achieve the expected efficacy against the mentioned parasites, it may be due to resistance and not to incorrect use, which is usually the most frequent cause of product failure.
Alternative chemical classes/active ingredients to prevent resistance of gastrointestinal roundworms through product rotation:
- Benzimidazoles, e.g. albendazole, febantel, fenbendazole, oxfendazole, etc. Similar or even worse resistance problems than levamisole.
- Macrocyclic lactones e.g. abamectin, doramectin, eprinomectin, ivermectin, moxidectin. Similar or even worse resistance problems than levamisole.
- Nitroxinil (limited spectrum of activity).
- Tetrahydropyrimidines, e.g. morantel, pyrantel (limited spectrum of activity).
- Salicylanilides, e.g. closantel (limited spectrum of activity).
These alternative products may not be available in all countries, or may not be available as pour-ons.
Learn more about resistance and how it develops.
Are the active ingredients of this product ORIGINAL* or GENERICS**?
*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.
COUNTRIES where this brand/product is marketed (maybe under another TM): UK, Ireland and other EU countries.
GENERIC BRANDS available? YES, but rather few pour-ons in most countries.
Click here to learn more about GENERIC vs. ORIGINAL drugs.
For an overview on the most used antiparasitic pour-on brands click here.
LEVACIDE Pour-on for Cattle from NORBROOK is one of the numerous wormers for livestock containing levamisole.
Levamisole is a veteran broad-spectrum anthelmintic active ingredient introduced already in the 1960s (by JANSSEN) and since then massively used in livestock worldwide against gastrointestinal roundworms and lungworms. It has no efficacy whatsoever against flukes, tapeworms and against any external parasitres of livestock (ticks, flies, lice, etc).
Levamisole is mostly used in drenches for oral administration, and in some countries also in injectables. Pour-on administration is often more convenient than those other delivery forms, but has also disadvantages. In several scientific studies it has been shown that topically administered antiparasitics (e.g. ivermectin, fluazuron) are not "automatically" absorbed through the skin. Licking (self licking or licking of other treated animals) may account for >50% of the total intake. And individual cattle show a different licking behavior. An important practical consequence is that the quantity that is finally ingested and is therefore available for the control of gastrointestinal worms depends on the licking behavior of the treated animals. "High lickers" can be overdosed, whereas "low lickers" can be underdosed. And chronic underdosing of animals in a herd may enhance development of resistance to ivermectin in gastrointestinal roundworms. To our knowledge such effect of licking on topically administered levamisole has not been investigated but must be assumed.
Absorption through the skin is also negatively affected by the thickness of the skin and the hair coat, by dust and mud on the coat, by product lost on fences and yards, etc, factors that don't play a role after injection or drenching. In contrast with drenches or injectables, pour-on formulations should not be administered to wet animals, and rain shortly before (up to 6 hours) or after administration can cause product run-off and thus under-dosing. The pour-ons shouldn't be administered by strong winds that may blow away part of the product and/or contaminate the workers.
For all these reasons efficacy after pour-on administration is usually less reliable than after oral administration or injection.
There are also numerous mixtures of levamisole with other active ingredients.
Click here for general information on good practices for the prevention and control of gastrointestinal worms in livestock.
This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics.
Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.
In case of doubt contact the manufacturer or a veterinary professional