Brand: PYRATAPE P HORSE WORMER 40% w/w,

Company: MSD ANIMAL HEALTH

FORMULATION: «oral paste» in pre-charged syringes

ACTIVE INGREDIENT(S): pyrantel embonate (=pamoate): 40% (= 400 g/kg)

CHEMICAL CLASS of the active ingredient(s): tetrahydropyrimidine

INDICATIONS

HORSES & PONIES

PARASITES CONTROLLED* (spectrum of activity)

* Country-specific differences may apply: read the product label.

• Pyrantel embonate has a broad spectrum of activity, including activity against:
• Large strongyles: Stronglylus vulgaris, S. edentatus, S. equinus.
• Small strongyles: Trichonema spp. (Cyathostomes), Triodontophorus spp.
• Pinworms: Oxyuris equi, Probstmayria vivipara.
• Large roundworms: Parascaris equorum.
• Tape worms: Anoplocephala perfoliata.

RECOMMENDED DOSE*

*Can be slightly different in some countries: read the product label!

• 19 mg pyrantel embonate per kg bodyweight for the control and treatment of strongyles (redworm), Oxyuris (seatworm/pinworm) and Parascaris (roundworm).
• 38 mg pyrantel embonate per kg bodyweight (twice the dose rate for strongyles) for the control and treatment of Anoplocephala perfoliata (tapeworm).
• The complete content of one syringe contains 11.4g pyrantel embonate (6 graduated doses of 1.9g) in 28.5g paste and is sufficient for the treatment of 600kg bodyweight. Each graduation of the syringe is sufficient for the treatment of 100kg body-weight.

SAFETY

LD50 (acute oral) in rats: >5000 mg/kg

Estimated hazard class according to the WHO: not applicable for veterinary medicines

Suspected poisoning? Read the articles on pyrantel safety in this site.

Withholding periods (=withdrawal times) for meat (country-specific differences may apply: read the product label)

• MEAT & OFFAL: UK: Not to be used in horses and ponies intended for human consumption. Treated horses may never be slaughtered for human consumption. The horse must have been declared as not intended for human consumption under national horse passport legislation.

WARNING !!!: Never use on humans, dogs or cats

You may be interested in the following articles in this site dealing with the general safety of veterinary products:

• Safety for humans
• Safety for domestic animals
• Safety for the environment
• Hazard classifications of pesticides

RESISTANCE PREVENTION

Risk of resistance? YES

• Parascaris equorum: Cases of resistance to pyrantel have been reported (e.g. in Europe, the USA and Brazil).
• Small strongyles (cyathostomes): Cases of resistance to pyrantel have been reported (e.g. in the EU, USA and Canada).

This means that if this product does not achieve the expected efficacy against the mentioned parasites, it may be due to resistance and not to incorrect use, which is usually the most frequent cause of product failure.

Alternative chemical classes/active ingredients to prevent resistance of gastrointestinal roundworms through product rotation:

• Benzimidazoles, mainly fenbendazole, mebendazole, etc. But they also have similar or even worse resistance problems than pyrantel
• Imidazothiazoles, mainly levamisole. Not approved for use in horses in many countries.
• Macrocyclic lactones: mainly ivermectin, moxidectin. But tolerance or resistance to these compounds have also been reported in Europe (e.g. in the UK, Germany, Italy), the USA, and Brazil.

These alternative products may not be available in all countries, or may not be available as oral pastes or gels.

Learn more about resistance and how it develops.

MARKETING

Are the active ingredients of this product ORIGINAL* or GENERICS**?

GENERICS

*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.

COUNTRIES where this product is marketed: UK and other EU countries.
GENERIC BRANDS available? YES

Click here to learn more about GENERIC vs. ORIGINAL drugs.

COMMENTS

This product is a classic oral paste dewormer for horses from MSD ANIMAL HEALTH with generic pyrantel.

Pyrantel is a veteran tetrahydropyrimidine introduced in the 1960s (by PFIZER → ZOETIS) that is moderately used in horses, abundantly in pets, but rather scarcely in ruminants. It is a narrow-spectrum anthelmintic effective against roundworms and a few tapeworms in the gut, but not against those in other organs (e.g. the lungs, the skin, etc). It is also ineffective against gastric bots (Gasterophilus spp) or whatever external parasites. 

For an overview and a list of the most used oral paste & gel brands click here.

DISCLAIMER

This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics. 

Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.

In case of doubt contact the manufacturer or a veterinary professional.