Brand: LICE 'N' SIMPLE
FORMULATION: «pour-on» for topical administration.
ACTIVE INGREDIENT(S): triflumuron 25 g/L (= 2.5%)
CHEMICAL CLASS of the active ingredient(s): insect growth regulator (= IGR, benzoylphenyl urea)
PARASITES CONTROLLED (spectrum of activity)
- Control of body lice Werneckiella (Bovicola) in horses with a single treatment.
- 1 mL product/10 kg bodyweight (equivalent to 2.5 mg/kg bw)
* Read the product label for further details on dosing and administration.
- LD50 (acute oral) in rats: >5000 mg/kg (estimate calculated according to the WHO based on the LD50 of the a.i.)
- LD50 (acute dermal) in rats: >5000 mg/kg (estimate calculated according to the WHO based on the LD50 of the a.i.)
- Estimated hazard class of the a.i. according to the WHO classification of pesticides: U, unlikely to present acute hazard in normal use.
Withholding periods (=withdrawal times) for meat, milk (country-specific differences may apply: read the product label)
- Meat: Australia: 28 days
- Milk for human consumption: Not approved in Australia.
You may be interested in the following articles in this site dealing with the general safety of veterinary products:
- Safety for humans
- Safety for domestic animals
- Safety for the environment
- Hazard classifications of pesticides
Risk of resistance? YES
There are no reports on resistance of horse body lice to triflumuron. However, sheep body lice of the same genus (Bovicola) have developed resistance to several benzoylureas (diflubenzuron, triflumuron) and it must be assumed that horse body lice may develop resistance if submitTed to prolonged selection pressure with such products. Thus it is a good idea to periodically change the active ingredient (rotation) used against these parasites.
Alternative chemical classes/active ingredients for product rotation to prevent resistance of body lice to triflumuron:
- Synthetic pyrethroids
- Macrocyclic lactones (e.g. ivermectin)
- Neonicotinoids (e.g. imidacloprid). No efficacy against blowfly strike.
- Spinosad. Short protection periods.
These alternative products may not be available in all countries, or may not be available as pour-ons for horses
Learn more about resistance and how it develops.
Are the active ingredients of this product ORIGINAL* or GENERICS**?
*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.
COUNTRIES where this brand/product is marketed: Australia, New Zealand
GENERIC BRANDS available? YES, but rather few for horses, if at all.
Click here to learn more about GENERIC vs. ORIGINAL drugs.
For an overview on the most used antiparasitic pour-on brands click here.
LICE 'N' SIMPLE is a pour-on for horses from JUROX that containins generic trifumuron.
Triflumuron is a broad-spectrum insect growth regulator (IGR) belonging to the benzoylphenyl-ureas introduced in the 1980s (by BAYER). It is effective against immature stages (larvae, nymphs, etc.) of numerous insects but not against adult stages. It is scarcely used in sheep and horses but only in Australia and New Zealand, not in Europe or the US. It is not used so far in other livestock or in pets. It is also used moderately against agricultural and household pests.
It is important to understand that this and other products containing insect growth regulators do not kill adult lice that may infect animals at the moment of treatment, i.e. they don't have a knock-down effect. What they do is to prevent further development of immature stages. Larvae and/or nymphs fail to molt to the next stage and die. Thus infected animals treated may need a few weeks to become free of lice.
This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics.
Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.
In case of doubt contact the manufacturer or a veterinary professional.