Brand: VETGUARD ®
PARASITES CONTROLLED* (spectrum of activity)
- Ticks including Brown dog tick (Rhipicephalus sanguineus), American dog tick (Dermacentor variabilis) & deer ticks (Ixodes scapularis)
- Chewing lice (Felicola subrostratus)
* Can be slightly different in some countries: read the product label!
- Cats ≥1 kg =≥2.2 lbs. bw: 1 pipette with 0.5 mL (equivalent to ≤48.5 mg/kg fipronil)
- LD50 (acute oral) in rats: ~1030 mg/kg (calculated according to the WHO based on the LD50 of fipronil)
- Estimated Hazard Class calculated according to the WHO: II moderately hazardous (based on the LD50, learn more)
Suspected poisoning? Read the article on fipronil safety in this site.
WARNING !!!: Never use on cats pipettes approved only for dogs. Learn more about spot-ons and their safety.
You may be interested in the following articles in this site dealing with the general safety of veterinary products:
- Safety for humans
- Safety for domestic animals
- Safety for the environment
- Hazard classifications of pesticides
Risk of resistance? YES, low to moderate in:
So far there are only very few confirmed reports on flea resistance to fipronil, 25 years after its introduction for flea control. But there are rumors that the number of product failures is increasing, mainly in the US. Fleas have developed resistance to several other insecticides (e.g. carbamates, organophosphates and pyrethroids) and are certainly capable of becoming resistant to fipronil as well. Experience shows that prolonged and uninterrupted use of any insecticide on fleas (including fripronil) bears the risk of resistance development.
There are no reports on resistance of brown dog ticks to fipronil, but moderate resistance to pyrethroids has been reported in several countries (e.g. Brazil, Panama, Spain, USA).
Alternatives to prevent resistance through product rotation:
- Carbamates (F+T*), e.g. carbaryl, propoxur
- Indoxacarb (F*)
- Insect Development Inhibitors (F*), e.g. lufenuron
- Isoxazolines (F+T*), e.g. afoxolaner, fluralaner, sarolaner
- Macrocyclic lactones (F*), e.g. selamectin
- Neonicotinoids (F*), e.g. dinotefuran, imidacloprid, nitenpyram
- Organophosphates (F+T*), e.g. chlorpyrifos, coumaphos, diazinon, fenthion, etc.
- Spinosyns (F*), e.g. spinetoram, spinosad
*F = effective against fleas; T = effective against ticks.
These alternative products may not be available in all countries, or may not be available as spot-ons.
Resistance of fleas and brown dog ticks to carbamates, organophosphates and pyrethroids is not uncommon in several countries, including the USA.
Are the active ingredients of this product ORIGINAL* or GENERICS**?
- Fipronil: GENERIC (introduced in the 1990s)
*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.
COUNTRIES where this product is marketed: USA
GENERIC BRANDS available? YES; this product contains generic fipronil.
Click here to learn more about GENERIC vs. ORIGINAL drugs.
Administered about every 4 weeks controls established flea infestations and prevents flea populations to develop in the pets environment, but only if all the dogs and cats in the same household are treated. It also kills several tick species (e.g. Dermacentor spp, Ixodes spp, Rhipicephalus sanguineus, Amblyomma americanum, etc,) and chewing lice (Felicola subrostratus).
Fipronil is a broad-spectrum insecticide and acaricide belonging to the phenylpyrazoles introduced in the late 1980s (by RHÔNE MÉRIEUX → MERIAL). It is massively used in pets and agriculture, and also moderately used against household pests and in some countries in livestock too. There are hundreds of generic brands with fipronil.
Nowadays, after fipronil lost patent protection there are dozens of flea spot-ons for dogs and cats with generic fipronil, alone or in several mixtures with other active ingredients. But not all the generic brands are available in all countries.
- Most topical products kill or sterilize the parasites before they bite and suck blood on the pet, whereas systemic products kill or sterilize the parasites only after their blood meal.
- Topical products cannot be vomited.
- Spot-ons and collars are very convenient to administer.
- There is a larger choice of topical products.
But topical products have also some disadvantages:
- Topical products contaminate the pet's hair coat and it is advisable for children and also adults to avoid contact with the pet for several days after treatment.
- Topical products may not control parasites in some parts of the pet's body (e.g. the ears, below the tail, between the legs, etc.), whereas systemic products reach the blood-sucking parasites through the blood wherever they are.
- Efficacy of topical products may be reduced or shortened through exposure to dirt, sun, shampooing, washing, rain, baths, etc., whereas efficacy of systemic products is independent from these factors.
For an overview and a list of the most popular pet antiparasitics for flea, tick, lice and/or mite control click here.
This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics.
Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.
In case of doubt contact the manufacturer or a veterinary professional.