Brand: SAFE-GUARD ® .75% DEWORMER
Company: MERCK ANIMAL HEALTH
INDICATIONS: CATTLE (Beef & Dairy), SWINE & TURKEY
PARASITES CONTROLLED (spectrum of activity)
- Gastrointestinal worms: barberpole worms (Haemonchus contortus); brown stomach worms (Ostertagia ostertagi); small stomach worms (Trichostrongylus axei); hookworms (Bunostomum phlebotomum); threadnecked intestinal worms (Nematodirus helvetianus); small intestinal worms (Cooperia punctata and Cooperia oncophora); bankrupt worms (Trichostrongylus colubriformis); and nodular worms (Oesophagostomum radiatum).
- Lungworms: Dictyocaulus viviparus.
- Gastrointestinal worms: Adult and larvae (L3, L4 stages, liver, lung, intestinal forms) large roundworms (Ascaris suum); nodular worms (Oesophagostomum dentatum, Ornithostrongylus quadrispinulatum); small stomach worms (Hyostrongylus rubidus); whipworms, adult and larvae (L2, L3, L4 stages - intestinal mucosal forms, (Trichuris suis).
- Lungworms: (Metastrongylus apri, Metastrongylus pudendotectus).
- Kidney worms: Adult and larvae (Stephanurus dentatus).
- Roundworms: adult and larvae (Ascaridia dissimilis); cecal worms, adult and larvae (Heterakis gallinarum)
- Swine: 3 to 12 Day Treatment (Total Dosage, 4.08 mg/lb body weight).
- Cattle, beef & dairy: One Day Treatment (2.27 mg/lb body weight).
- Turkey: Six Day Treatment (14.5 gm/ton of complete feed).
- Read the product label for specific detail on dosage.
* Country-specific differences may apply: read the product label.
- LD50 (acute oral) in rats: >10000 mg/kg (for the a.i.)
- LD50 (acute dermal) in rats: n.a.
Suspected poisoning? Read the article on fenbendazole safety in this site.
Withholding periods (=withdrawal times) in days for meat & milk (country-specific differences may apply: read the product label)
- Cattle: Meat 13 days; No milk withdrawal
WARNING !!!: Never use on humans, dogs or cats
You may be interested in the following articles in this site dealing with the general safety of veterinary products:
- Safety for humans
- Safety for domestic animals
- Safety for the environment
- Hazard classifications of pesticides
Risk of resistance? HIGH in cattle; LOW in swine and turkey
Resistance of gastrointestinal roundworms to all benzimidazoles (incl. fenbendazole) in ruminants is a very serious and increasing problem worldwide, particularly in sheep and goats, but also in cattle. The most affected worm species in cattle are: Cooperia spp, Haemonchus spp, Ostertagia spp, Trichostrongylus spp, Oesophagostomum spp. This means that if this product does not achieve the expected efficacy against the mentioned parasites in cattle, it can be due to resistance and not to incorrect use, which is usually the most frequent cause of product failure.
There are a few reports on resistance of Oesophagostomum worms to benzimidazoles, levamisole and pyrantel (mainly in Europe) but so far the problem is much less frequent and severe than in sheep or cattle. This means that if this product does not achieve the expected efficacy against the mentioned parasites in swine or turkey, there is a certain risk that it is due to resistance and not to incorrect use, which is usually the most frequent cause of product failure.
- Levamisole. Resistance to levamisole has been reported in a few countries, but is usually less strong and frequent than to benzimidazoles.
- Macrocyclic lactones (e.g. abamectin, doramectin, eprinomectin, ivermectin, moxidectin, etc.).
- Tetrahydropyrimidines (e.g. morantel, pyrantel): effective only against certain gastrointestinal roundworms. Not available in some countries. Resistance to morantel has been reported in some countries.
- Piperazine. Effective only against certain gastrointestinal roundworms (mainly ascarids).
These alternative products may not be available in all countries or may not be effective against all the concerned parasites.
Are the active ingredients of this product ORIGINAL* or GENERICS**?
*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.
COUNTRIES where this brand/product is marketed: USA
GENERIC BRANDS available? Yes, in some countries, but not too many
Click here to learn more about GENERIC vs. ORIGINAL drugs.
Click here for an overview on the most used antiparasitic feed additives and medicated feeds for livestock and horses.
SAGE-GUARD is a brand from MERCK ANIMAL HEALTH for numerous wormers containing fenbendazole, in this case a specific liquid formulation cattle, swine & turkey.
Fenbendazole is a veteran anthelmintic introduced in the 1970s (by HOECHST, now MSD = MERCK ANIMAL HEALTH). Fenbendazole has a broad-spectrum of activity against roundworms (gastrointestinal and pulmonary) and, depending on the dose also against tapeworms, but is ineffective against flukes. Fenbendazole also kills eggs of roundworms (ovicidal activity). As all benzimidazoles, fenbendazole has no efficacy whatsoever against external parasites (ticks, flies, lice, mites, etc). Among the benzimidazoles, fenbendazole is quite comparable with oxfendazole in terms of efficacy and safety. Fenbendazole is abundantly used worldwide in numberless generic brands for livestock, horses and pets.
As all benzimidazoles (as well as other anthelmintics such as levamisole, monepantel, and tetrahydropyrimidines), fenbendazole for oral administrartion has no residual effect, i.e. it kills the parasites shortly after administration, but as soon as medicated feeding is interrupted it does not significantly protect the animals against re-infestation by infective stages in their environment.
Both for livestock and pets fenbendazole is often used in combinations that broaden the spectrum of activity or try to overcome potential resistance. Typical mixtures for livestock include a flukicide (e.g. closantel, etc.) and/or a macrocyclic lactone, and/or levamisole, although such mixtures are not approved everywhere. For dogs and cats it is often combined with a taenicide (e.g. praziquantel).
Click here for general information on good practices for the prevention and control of gastrointestinal worms in livestock.
This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics.
Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.
In case of doubt contact the manufacturer or a veterinary professional.