Brand: SYKES BIG L
DELIVERY FORM: «additives and medicated feeds» for oral administration.
ACTIVE INGREDIENT(S): levamisole (hydrochloride): 14 g/L (equivalent to 16 g/L levamisole hydrochloride)
CHEMICAL CLASS of the active ingredient(s): imidazothiazole
INDICATIONS: PIG & POULTRY
PARASITES CONTROLLED* (spectrum of activity)
- Large Round worms (Ascaris suum)
- Mature/Immature Stomach Worms (Hyostrongylus rubidus)
- Nodule Worm (Oesophagostomum dentatum)
- Lungworm (Metastrongylus spp)
- Mature Kidney Worm (Stephanurus dentatus) NSW and QLD Only
- Large Roundworms (Ascaridia galli)
- Caecal Worm (Heterakis gallinarum)
- Hairworm (Capillaria spp)
* Country-specific differences may apply: read the product label.
- Dose Rate for Pigs: Oral Drench : 1mL/2kg (5mL/10kg) live weight.
- Administration: VETSENSE KILVERM may be given as a drench or mixed with the feed. It is important that it is consumed quickly for best results. Make sure that the pigs are slightly hungry before administration, that they have ample feeding space, and that animals of comparative size be treated together so that small or weak pigs will be receiving enough share of medicated feed.
- In Feed : Calculate accurately the weight of the pigs and dose accurately at the rate of 5mL/10kg, thus 10 pigs of 40kg will need 200mL. Add sufficient water or skim milk to just dampen the mash, pellets or grain, then mix thoroughly.
- If using skim milk, add the required amount to the milk and mix thoroughly before adding to the feed.
- Dilute 10mL of VETSENSE KILVERM in 200 mL of water for each 6 kg live weight. (1.75 mL of VETSENSE KILVERM in 35mL of water per 1kg live weight) Mix 40mL/litre water for 1 day.
- Repeat 2 weeks later.
- Mix with clean drinking water. For maximum efficiency it must be consumed in the shortest time possible. Withhold water from birds 2 hours before nightfall. The required amount of medicated water is then made available so that the birds can start drinking it at daylight. Replace with clean water after 8 hours or when medication is consumed.
- Birds under continuous light should be treated by withholding water for 2 hours then giving medicated water as above.
- Read the product label for further details on dosing.
- LD50 (acute oral) in rats: 180 mg/kg (for the a.i.)
- LD50 (acute dermal) in rats: n.a.
Suspected poisoning? Read the article on levamisole safety in this site.
Withholding periods (=withdrawal times)
- Meat: AUS: Pig 3 days; Poultry 7 days
- Eggs: AUS: NIL
WARNING !!!: Never use on humans, dogs or cats
You may be interested in the following articles in this site dealing with the general safety of veterinary products:
- Safety for humans
- Safety for domestic animals
- Safety for the environment
- Hazard classifications of pesticides
Risk of resistance? LOW
There are a few reports on resistance of Oesophagostomum worms to benzimidazoles, levamisole and pyrantel (mainly in Europe) but so far the problem is much less frequent and severe than in sheep or cattle.
This means that if this product does not achieve the expected efficacy against the mentioned parasites, there is a certain risk that it is due to resistance and not to incorrect use, which is usually the most frequent cause of product failure.
Alternative chemical classes/active ingredients to prevent resistance of gastrointestinal roundworms through product rotation in swine:
- Benzimidazoles, e.g. albendazole, febantel, fenbendazole, oxfendazole, etc.
- Macrocyclic lactones (e.g. abamectin, doramectin, eprinomectin, ivermectin, moxidectin, etc.).
- Tetrahydropyrimidines (e.g. morantel, pyrantel): effective only against certain gastrointestinal roundworms. Not available in some countries. Resistance to morantel has been reported in some countries.
- Piperazine. Effective only against certain gastrointestinal roundworms (mainly ascarids).
These alternative products may not be available in all countries or may not be effective against all the concerned parasites.
It is highly recommended to periodically check the resistance status of each property performing appropriate tests (e.g. fecal egg counts) under supervision of a veterinary doctor. Such tests are now routinely available for most producers in developed countries.
Learn more about resistance and how it develops.
Are the active ingredients of this product ORIGINAL* or GENERICS**?
*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.
COUNTRIES where this brand/product is marketed: Australia
GENERIC BRANDS available? Yes, in most countries.
Click here to learn more about GENERIC vs. ORIGINAL drugs.
Click here for an overview on the most used antiparasitic feed additives and medicated feeds for livestock and horses.
This product is a classic anthelmintic for pig & poultry from SYKES containing generic levamisole.
Levamisole is a veteran anthelmintic. It was introduced by JANSSEN already in the 1960s (NILVERM, RIPERCOL). It has a broad-spectrum of activity against roundworms (gastrointestinal and pulmonary) but no efficacy whatsoever against tapeworms and flukes. It is also completely ineffective against external parasites of livestock (ticks, flies, lice, mites, etc). Levamisole has been used massively worldwide in countless generic formulations for livestock. It still remains one of the most preferred low-cost anthelmintics for livestock worldwide. Usage in pets or horses is rather scarce. It is not used in agriculture.
As many other anthelmintics (e.g. benzimidazoles, tetrahydropyrimidines) levamisole administered orally has no residual effect, i.e. it kills the parasites shortly after administration, but does not significantly protect the animals against re-infestation by infective stages in their environment.
Thanks to its higher solubility in water levamisole is also available as a pour-on and as an injectable for livestock, but only in some countries.
This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics.
Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.
In case of doubt contact the manufacturer or a veterinary professional.