Brand: BENZICARE LAMB & SHEEP DRENCH
Company: ALL FARM
INDICATIONS: SHEEP & LAMBS
PARASITES CONTROLLED (spectrum of activity)
- Gastrointestinal roundworms: Haemonchus contortus (adults, immatures, inhibited stages), Ostertagia spp, Trichostrongylus spp, Nematodirus spp, Cooperia spp, Oesophagostomum columbianum, Chabertia ovina, Bunostomum trigonocephalum,
- Lungworms: Dictyocaulus filaria
- Tapeworms: Moniezia spp.
Sheep & lambs: 1 ml product/4 kg bw, equivalent to 12.5 mg/kg mebendazole.
- ≤4 kg: 1.0 ml product
- 5-10 kg: 2.5 ml product
- 11-16 kg: 4.0 ml product
- 17-20 kg: 5 ml product
- 21-30 kg: 7.5 ml product
- 31-40 kg: 10.0 ml product
- 41-50 kg: 12.5 ml product
- 51-60 kg: 15.0 ml product
- 61-70 kg: 17.5 ml product
- 71-80 kg: 20.0 ml product
- LD50 (acute oral) in rats: a.i. > 1280 mg/kg
- LD50 (acute dermal) in rats: n.a.
Suspected poisoning? Read the article on mebendazole safety in this site.
Withholding periods (=withdrawal times) for meat & milk (country-specific differences may apply: read the product label)
- Meat: 7 days;
- Milk: Do not use in ewes which are producing or may in the future produce milk or milk products for human consumption.
WARNING !!!: Never use on humans, dogs or cats
You may be interested in the following articles in this site dealing with the general safety of veterinary products:
- Safety for humans
- Safety for domestic animals
- Safety for the environment
- Hazard classifications of pesticides
Risk of resistance: YES.
Resistance of gastrointestinal roundworms to all benzimidazoles (incl. mebendazole) in ruminants is a very serious and increasing problem worldwide, particularly in sheep and goats, but also in cattle. The most affected worm species are: Haemonchus spp, Ostertagia spp /Teladorsagia spp, Trichostrongylus spp, Nematodirus spp and Chabertia ovina.
This means that if this product does not achieve the expected efficacy against the mentioned parasites, it may be due to resistance and not to incorrect use, which is usually the most frequent cause of product failure.
- Macrocyclic lactones (e.g. abamectin, doramectin, eprinomectin, ivermectin, moxidectin, etc.). Resistance to macrocyclic lactones is also increasing and strengthening quickly in many countries.
- Levamisole. Resistance to levamisole has been reported in most countries, but is usually less strong and frequent than to benzimidazoles.
- Monepantel: available only for sheep & goats in some countries (e.g. Australia, UK & EU, New Zealand). First cases of resistance reported in New Zealand in 2013.
- Tetrahydropyrimidines (e.g. morantel, pyrantel): effective only against certain gastrointestinal roundworms. Not available in some countries. Resistance to morantel has been reported in some countries.
- Nitroxinil: effective only against certain gastrointestinal roundworms (e.g. Bunostomum spp, Haemonchus spp, Oesophagostomum spp). Not available in some countries.
These alternative products may not be available in all countries or may not be available as drenches.
It is highly recommended to periodically check the resistance status of each property performing appropriate tests (e.g. fecal egg counts) under supervision of a veterinary doctor. Such tests are now routinely available for most producers in developed countries.
Are the active ingredients of this product ORIGINAL* or GENERICS**?
*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.
COUNTRIES where this brand/product is marketed: Australia
GENERIC BRANDS available? Yes, but not a lot in most countries, if at all.
Click here to learn more about GENERIC vs. ORIGINAL drugs.
For an overview on the most used antiparasitic drenches click here.
This product is a classic anthelmintic drench from ALL FARM ANIMAL HEALTH with generic mebendazole.
Mebendazole, a benzimidazole, is a veteran anthelmintic (introduced in the 1970s by JANSSEN). It has a broad spectrum of activity against gastrointestinal roundworms, lungworms and some tapeworms. It is ineffective against flukes and any external parasites. It is more frequently used in horses and pets than in ruminants. It is not used in agriculture.
As all benzimidazoles (as well as other anthelmintics such as levamisole, monepantel, and tetrahydropyrimidines), mebendazole administered as a drench has no residual effect, i.e. it kills the parasites shortly after administration, but does not significantly protect the animals against re-infestation by infective stages in their environment.
Unfortunately, resistance of several gastrointestinal roundworms to all benzimidazoles (including mebendazole) is already very high and very frequent worldwide in sheep and goats, slightly lower in cattle, which has significantly reduced their usage in livestock.
Nowadays more convenient pour-ons and injectables containing macrocyclic lactones (e.g. abamectin, doramectin, eprinomectin, ivermectin, moxidectin) are often preferred over drenches with benzimidazoles or combinations. Macrocyclic lactones also ensure several weeks protection against re-infestation by several worm species, in contrast with all benzimidazoles that lack any residual effect.
In ruminants, reducing the amount of feed slows down the exit flow of the rumen and prolongs the time during which the active ingredient remains there and is absorbed. Consequently it is advisable to reduce the access of animals to feed (especially to fresh pasture, not to water) 24 hours before administration. For the same reason, it is better to keep the animals away from food for about 6 hours after drenching. However sick or weak animals should not be kept away from food and fasting animals should have access to water. In cattle, a fiber-rich diet also increases the bioavailability of fenbendazole.
Mebendazole is a solid compound poorly soluble in water and in drenches it is formulated as a suspension (not as a solution or as an emulsion). A key unfavorable feature of all suspensions is that the suspended solid particles tend to fall down to the bottom of the container and sediment, very much like sand in water. This means that suspensions must be thoroughly shaken before use. How fast the suspension sediments and how easily shaking the container redistributes the suspension depends on the formulation quality. A good formulation sediments slowly and shaking will re-suspend it quickly. Bad formulations sediment quickly and shaking re-suspends them slowly.
Thoroughly shaking suspensions before use is crucial for efficacy. If the active ingredient remains in the sediment, a few animals may get most of the active ingredient and will be overdosed, and the large majority will get almost only solvents and will be underdosed.
Click here for general information on good practices for the prevention and control of gastrointestinal worms in livestock.
This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics.
Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.
In case of doubt contact the manufacturer or a veterinary professional.