Brand: TEVRAPET ACTIVATE II COLLAR
FORMULATION: «collar» impregnated with insecticides/tickicides
- DELTAMETHRIN 40 g/kg (= 4.0%)
- PYRIPROXYFEN: 5.0 mg/kg (= 0.5%)
CHEMICAL CLASS of the active ingredient(s):
- Deltamethrin: SYNTHETIC PYRETHROID
- Pyriproxyfen: JUVENILE HORMONE ANALOGUE
PARASITES CONTROLLED (spectrum of activity)
- Kills fleas and ticks for up to 6 months
- Repells mosquitoes.
Since the active ingredient is released slowly from the collar's matrix, it is not possible to calculate the exact dose that the animals are exposed to in a particular moment.
- LD50 (acute oral) in rats: n.a. for the collar.
- Deltamethrin: 128 to >5000 mg/kg depending on the carrier.
- Pyriproxyfen: >5000 mg/kg
Suspected poisoning? Read the articles on deltamethrin safety and pyriproxyfen safety in this site.
WARNING !!!: Never use on cats collars approved only for dogs. Learn more about insecticide-impregnated collars and their safety.
You may be interested in the following articles in this site dealing with the general safety of veterinary products:
- Safety for humans
- Safety for domestic animals
- Safety for the environment
- Hazard classifications of pesticides
Risk of resistance? YES, moderate in:
- fleas, mainly the cat flea, Ctenocephalides felis
- brown dog ticks, Rhipicephalus sanguineus
Resistance of fleas to synthetic pyrethroids is common in many countries, including the USA, and resistance of brown dog ticks (Rhipicephalus sanguineus) has been reported in several places (e.g. the USA, Brazil, Spain, Panama). For this reason efficacy against these parasites may be weaker and protection shorter than expected.
Alternatives to prevent resistance through product rotation:
- Amitraz (T*): toxic to cats!
- Carbamates (F+T*), e.g. carbaryl, propoxur
- Indoxacarb (F*)
- Insect Development Inhibitors (F*), e.g. lufenuron
- Isoxazolines (F+T*), e.g. afoxolaner, fluralaner, sarolaner
- Macrocyclic lactones (F*), e.g. selamectin
- Neonicotinoids (F*), e.g. dinotefuran, imidacloprid, nitenpyram
- Organophosphates (F+T*), e.g. chlorpyrifos, coumaphos, diazinon, fenthionn, etc.
- Phenylpyrazoles (F+T*), e.g. fipronil, pyriprole
- Spinosyns (F*), e.g. spinetoram, spinosad
*F = effective against fleas; T = effective against ticks.
These alternative products may not be available in all countries, or may not be available as collars.
Resistance of fleas and brown dog ticks to carbamates and organophosphates is not uncommon in several countries, including the USA.
Learn more about resistance and how it develops.
Are the active ingredients of this product ORIGINAL* or GENERICS**?
- Deltamethrin: GENERIC (introduced in the 1970s by ROUSSEL-UCLAF)
- Pyriproxyfen: GENERIC (introduced in the 1980s by SUMITOMO)
*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.
COUNTRIES where this product is marketed (maybe under another TM): USA
GENERIC BRANDS available? Perhaps not with the same composition. This product itself contains generic deltamethrin and pyriproxyfen
Click here to learn more about GENERIC vs. ORIGINAL drugs.
TEVRAPET ACTIVATE II COLLAR is an insecticide impregnated collar for dogs from TEVRA containing generic deltamethrin. and pyriproxyfen. It is exactly the same as VETALITY AVANTECT II COLLAR also from TEVRA.
Pyriproxyfen (Nylar) is a veteran insect development inhibitor introduced in the 1980s (by SUMITOMO) scarcely used in pets. Its only effect is to stop development of flea eggs and larvae. It has no effect whatsoever against adult fleas, ticks or mosquitoes.
This combination of two active ingredients of different chemical classes makes also sense regarding resistance prevention, because it means attacking fleas through two different mechanisms of action, which is vastly assumed to help preventing or at least delaying resistance development.
Topical products (mainly spot-ons and insecticide-impregnated collars) have some advantages over systemic products (mainly tablets for oral administration and injectables):
- Most topical products kill or sterilize the parasites before they bite and suck blood on the pet, whereas systemic products kill or sterilize the parasites only after their blood meal.
- Topical products cannot be vomited.
- Spot-ons and collars are very convenient to administer.
- There is a larger choice of topical products.
But topical products have also some disadvantages:
- Topical products contaminate the pet's hair coat and it is advisable for children and also adults to avoid contact with the pet for several days after treatment.
- Topical products may not control parasites in some parts of the pet's body (e.g. the ears, below the tail, between the legs, etc.), whereas systemic products reach the blood-sucking parasites through the blood wherever they are.
- Efficacy of topical products may be reduced or shortened through exposure to dirt, sun, shampooing, washing, rain, baths, etc., whereas efficacy of systemic products is independent from these factors.
For an overview and a list of the most popular pet antiparasitics for flea, tick, lice and/or mite control click here.
This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics.
Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.
In case of doubt contact the manufacturer or a veterinary professional.