Brand: EXZOLT ®
Company: MSD ANIMAL HEALTH
INDICATIONS: CHICKENS: pullets, breeders and layer hens
PARASITES CONTROLLED* (spectrum of activity)
- Red fowl mite, Dermanyssus galinae
- 0,5 mg/kg (equivalent to 0.05 ml solution) twice at a seven day interval.
- If treatment has to be repeated wait at least 3 months after the last treatment.
- Read the product label for further details on dosing.
- LD50 (acute oral) in rats: >5000 mg/kg
Suspected poisoning? Read the article on fluralaner safety in this site.
Withholding periods (=withdrawal times)
- Meat: UE: 14 days
- Eggs: UE: NIL
You may be interested in the following articles in this site dealing with the general safety of veterinary products:
- Safety for humans
- Safety for domestic animals
- Safety for the environment
- Hazard classifications of pesticides
Risk of resistance? LOW
Due to its recent introduction into the poultry market (2017) there are so far no reports on red fowl mite (Dermanyssus gallinae) resistance to isoxazolines or on cross-resistance with other parasicide. However, these mites have been capable of developing high resistance to almost all chemical classes used in the past for their control, mainly carbamates, organophosphates and synthetic pyrethroids. Experience has shown that uninterrupted use of any parasiticide bears the risk of resistance development. Thus it is highly recommended to periodically alternate the chemical class (a process called rotation) of the products used for their control in order to at least delay resistance development.
- Carbamates; resistance is not uncommon in many regions.
- Organophosphates; resistance is not uncommon in many regions.
- Synthetic pyrethroids; resistance is very frequent and high worldwide.
In some countries abamectin products are also approved for use on poultry.
These alternative products may not be available in all countries, or may not be effective against all the concerned parasites, or may not be available as feed additives.
Are the active ingredients of this product ORIGINAL* or GENERICS**?
*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.
COUNTRIES where this brand/product is marketed: UE, including UK
GENERIC BRANDS available? NO
Click here to learn more about GENERIC vs. ORIGINAL drugs.
Click here for an overview on the most used antiparasitic feed additives and medicated feeds for livestock and horses.
EXZOLT is the first product containing an isoxazoline (in this case fluralaner) approved for use in production animals. After their introduction in 2013, isoxazolines were available only for use on pets, mainly on dogs against fleas and ticks.
It is also the first product approved that has a systemic mode of action against red fowl mites (Dermanyssus gallinae), i.e. once ingested by the host it reaches the parasites through the blood of the host. All classic products used so far against these mites are for topical administration (directly on the birds or only for premise treatment) and are contact, not systemic parasiticides.
Fluralaner is one of the first isoxazolines that was introduced as a veterinary parasiticide in 2013 (by MSD Animal Health). It is a broad spectrum systemic insecticide and acaricide. Through the host's blood it reaches the mites wherever they may bite the birds. Fluralaner starts killing mites 4 hours after administration. Its mode of action is different from all other parasiticides, i.e. it is effective against mites that are already resistant to those parasiticides that have been used until now. For the time being it is not used on livestock or horses. It is neither used in agricultural pesticides, nor against household pests or vectors.
This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics.
Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.
In case of doubt contact the manufacturer or a veterinary professional.