Flubendazole is a broad-spectrum anthelmintic effective against roundworms and, depending on the dose, also against some tapeworms as well. It is ineffective against flukes (e.g. Fasciola hepatica). It is completely ineffective against external parasites. Oral administration is the rule.
It is used moderately in swine and poultry (mainly in feed additives), but rather scarcely in dogs and cats. It is not used at all in ruminants and horses in most countries. It is not used in crop protection either.
In carnivores (incl. dogs and cats) delivery with the food increases the bioavailability of all benzimidazoles resulting in a better efficacy.
All benzimidazoles have almost no residual effect, i.e. they kill the parasites during a few hours after treatment but offer no significant protection against re-infestation.
Unfortunately, resistance of gastrointestinal roundworms to all benzimidazoles in sheep, goats, cattle and horses is a major problem in numerous countries. Not so yet in swine, poultry and pets.
The table below indicates some usual dosing recommendations for flubendazole issued by manufacturers or documented in the scientific literature. They may not be approved in some countries.
| Dosing recommendations for FLUBENDAZOLE |
||
| DOGS | ||
| Delivery | Parasites | Dose (against flubendazole-susceptible parasites) |
| Oral | Ancylostoma spp, Uncinaria spp | 22 mg/kg/day x 2-3 days |
| Oral | Ascarids (Toxocara, Toxascaris) |
22 mg/kg/day x 2-3 days |
| Oral | Trichuris vulpis | 22 mg/kg/day x 3 consecutive days |
| Oral | Strongyloides spp | 22 mg/kg/day x 3 consecutive days |
| Oral | Taenia spp | 22 mg/kg/day x 3 consecutive days |
| CATS | ||
| Delivery | Parasites | Dose (against flubendazole-susceptible parasites) |
| Oral | Ascarids (Toxocara, Toxascaris) |
22 mg/kg/day x 2 days |
| Oral | Strongyloides spp | 22 mg/kg/day x 2 days |
| Oral | Taenia spp | 22 mg/kg/day x 3 days |
| SWINE | ||
| Delivery | Parasites | Dose (against flubendazole-susceptible parasites) |
| Oral (additive) | Ascaris suum, adults | 16 ppm (=mg/kg) in feed during 2 days |
| Oral (additive) | Ascaris suum, juveniles | 30 ppm (=mg/kg) in feed during 9 days |
| Oral (additive) | Gastrointestinal roundworms | 30 ppm (=mg/kg) in feed during 5 days |
| Oral (additive) | Trichuris suis, adults | 30 ppm (=mg/kg) in feed during 5 days |
| Oral (additive) | Trichuris suis, juveniles | 30 ppm (=mg/kg) in feed during 10 days |
| Oral (direct) | Gastrointestinal roundworms | 5 mg/kg |
| POULTRY | ||
| Delivery | Parasites | Dose (against flubendazole-susceptible parasites) |
| Oral (additive) | Gastrointestinal roundworms | 20-30 ppm (=mg/kg) in feed during 7 days (partridges & pheasants 60 ppm) |
| Oral (additive) | Tapeworms | 60 ppm (=mg/kg) in feed during 7 days |
| Oral (additive) | Syngamus trachea | 63 ppm (=mg/kg) in feed during 3 days |
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Dosing recommendations for antiparasitics depend on national regulations. National regulatory authorities determine whether a product is approved for a given indication, i.e. use on a particular host at a specific dose and against a specific parasite. Check the labels of the products available in your country for specific information on approved indications.
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