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Flubendazole is a broad-spectrum anthelmintic effective against roundworms and, depending on the dose, also against some tapeworms as well. It is ineffective against flukes (e.g. Fasciola hepatica). It is completely ineffective against external parasites. Oral administration is the rule.

It is used moderately in swine and poultry (mainly in feed additives), but rather scarcely in dogs and cats. It is not used at all in ruminants and horses in most countries. It is not used in crop protection either.

In carnivores (incl. dogs and cats) delivery with the food increases the bioavailability of all benzimidazoles resulting in a better efficacy.

All benzimidazoles have almost no residual effect, i.e. they kill the parasites during a few hours after treatment but offer no significant protection against re-infestation.

Unfortunately, resistance of gastrointestinal roundworms to all benzimidazoles in sheep, goats, cattle and horses is a major problem in numerous countries. Not so yet in swine, poultry and pets.

The table below indicates some usual dosing recommendations for flubendazole issued by manufacturers or documented in the scientific literature. They may not be approved in some countries.

Dosing recommendations for FLUBENDAZOLE
DOGS
Delivery Parasites Dose (against flubendazole-susceptible parasites)
Oral Ancylostoma spp, Uncinaria spp 22 mg/kg/day x 2-3 days
Oral Ascarids (Toxocara, Toxascaris)
22 mg/kg/day x 2-3 days
Oral Trichuris vulpis 22 mg/kg/day x 3 consecutive days
Oral Strongyloides spp 22 mg/kg/day x 3 consecutive days
Oral Taenia spp 22 mg/kg/day x 3 consecutive days
CATS
Delivery Parasites Dose (against flubendazole-susceptible parasites)
Oral Ascarids (Toxocara, Toxascaris)
22 mg/kg/day x 2 days
Oral Strongyloides spp 22 mg/kg/day x 2 days
Oral Taenia spp 22 mg/kg/day x 3 days
SWINE 
Delivery Parasites  Dose (against flubendazole-susceptible parasites)
Oral (additive) Ascaris suum, adults 16 ppm (=mg/kg) in feed during 2 days
Oral (additive) Ascaris suum, juveniles 30 ppm (=mg/kg) in feed during 9 days
Oral (additive) Gastrointestinal roundworms 30 ppm (=mg/kg) in feed during 5 days
Oral (additive) Trichuris suis, adults 30 ppm (=mg/kg) in feed during 5 days
Oral (additive) Trichuris suis, juveniles 30 ppm (=mg/kg) in feed during 10 days
Oral (direct) Gastrointestinal roundworms 5 mg/kg
POULTRY
Delivery Parasites Dose (against flubendazole-susceptible parasites)
Oral (additive) Gastrointestinal roundworms 20-30 ppm (=mg/kg) in feed during 7 days (partridges & pheasants 60 ppm)
Oral (additive) Tapeworms 60 ppm (=mg/kg) in feed during 7 days
Oral (additive) Syngamus trachea 63 ppm (=mg/kg) in feed during 3 days

DISCLAIMER: Liability is denied for any possible damage or harm to persons, animals or any other goods that could follow the transmission or use of the information, data or recommendations in this site by any site visitor or third parties.

Dosing recommendations for antiparasitics depend on national regulations. National regulatory authorities determine whether a product is approved for a given indication, i.e. use on a particular host at a specific dose and against a specific parasite. Check the labels of the products available in your country for specific information on approved indications.


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