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Spinosad is a natural insecticide and acaricide with topical and systemic effect (after oral administration). It is highly effective against fleas in pets, against lice and blowfly strike (e.g. Lucilia spp) in sheep, and against poultry mites (e.g. Dermanyssus gallinae, Ornithonyssus spp). It is also effective against cattle ticks and cattle lice. It is not effective against internal parasites.

Spinosad is available for pets mainly in the form of tablets, for livestock in the form of concentrates for spraying or dipping. It is also used against agricultural pests.

So far there are not reports on resistance of veterinary parasites to spinosad. However resistance of houseflies (Musca domestica) to spinosad has been described in strains selected in the laboratory. And several cases have been reported in plant pests that have developed very high resistance ro spinosad.

The table below indicates some usual dosing recommendations for spinosad issued by manufacturers or documented in the scientific literature. They may not be approved in some countries.

Dosing recommendations for SPINOSAD
Delivery Parasites Dose (against spinosad-susceptible parasites)
Oral (tablets) Fleas 45-70 mg/kg; 4-5 weeks protection.
Delivery Parasites Dose (against spinosad-susceptible parasites)
Oral (tablets) Fleas 50-75 mg/kg; 4-5 weeks protection.
Delivery Parasites Dose (against spinosad-susceptible parasites)
Spray Cattle ticks 1500 ppm (=1500 mg/L); <90% control, residual effect <7 days.
Spray Lice 40 ppm (=40 mg/L); >95% control, residual effect ~7 weeks.
Pour-on Lice 2 mg/kg; >95% control, residual effect ~7 weeks.
Delivery Parasites Dose (against spinosad-susceptible parasites)
Spray Lice (Damalinia ovis) 20 ppm (=25 mg/L) in wash; 2-6 weeks off shears; replenishment at 40 ppm.
Dip Lice (Damalinia ovis) 10 ppm (=10 mg/L) in wash; 2-6 weeks off shears; replenishment at 15 ppm.
Jetting Lice (Damalinia ovis) 25 ppm (=25 mg/L) in wash; 6 weeks to 6 months off-shears
Jetting Blowfly strike 25 ppm (=mg/L) in wash. >6 weeks wool length; 4-6 weeks protection.
Pour-on Lice (Damalinia ovis) 8-15 mg/kg; 24 hours after shearing
Pour-on Lice (Damalinia ovis) 10-20 mg/kg; 6-12 months off-shears
Delivery Parasites Dose (against spinosad-susceptible parasites)
Spray Dermanyssus gallinae 2000-4000 ppm (= mg/L) in wash. ~0.4 L/animal; only for off-animal use (cages, floors, hiding places, etc.)
Spray Ornithonyssus spp 1035 ppm (=mg/L) in wash. ~0.4 L/animal; apply mainly around the vent.

DISCLAIMER: Liability is denied for any possible damage or harm to persons, animals or any other goods that could follow the transmission or use of the information, data or recommendations in this site by any site visitor or third parties.

In most finished products, efficacy and safety depend not only on the amount of active ingredient(s) but also on their formulations (i.e. the type and amount of so-called inert ingredients), particularly in injectables and in topical pour-ons and spot-ons. These inert ingredients can significantly affect the pharmacokinetic behavior (e.g. absorption through the skin or from the injection site, distribution within the body, spreading throughout the body surface, etc). Generic products usually contain the same amount of active ingredient(s) as the original product, but often in quite different formulations. In many cases, the curative (therapeutic) efficacy of the different formulations is quite comparable, but the protective (prophylactic) efficacy that determines the length of protection against re-infestations may be rather different.

Dosing recommendations for antiparasitics depend on national regulations. National regulatory authorities determine whether a product is approved for a given indication, i.e. use on a particular host at a specific dose and against a specific parasite. Check the labels of the products available in your country for specific information on approved indications.

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