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Piperazine is an antiparasitic active ingredient used in veterinary and human medicine. It is used in dogs, cats and livestock against some internal parasites (mainly roundworms). It is not used against agricultural and household pests.

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Piperazine is a narrow-spectrum anthelmintic effective maily against gastrointestinal ascarids. It is ineffective against tapeworms, flukes or external parasites. Oral administration is the rule. It is used moderately in swine and poultry (mainly as feed additives) and horses, rather scarcely in pets and only marginally in ruminants.

Pure piperazine (so-called piperazine base) is unstable in water. For this reason it is mostly used in the form of certain salts: adipate, citrate, etc. Eficacy depends on the piperazine base content. Piperazine citrate contains 35% piperazine base; piperazine adipate 37%, etc.

Piperazine (incl. its salts) has almost no residual effect, i.e. it kills the parasites during a few hours after treatment but offers no significant protection against re-infestation.

Piperazine and pyrantel seem to be pharmacologic antagonists and should not be administered simultaneously.

The table below indicates some usual dosing recommendations for piperazine issued by manufacturers or documented in the scientific literature. They may not be approved in some countries.

Dosing recommendations for PIPERAZINE
Delivery Parasites Dose (against piperazine-susceptible parasites)
DOGS
Oral (base) Ascarids (Toxocara, Toxascaris) 100-200 mg/kg
Oral (base) Uncinaria stenocephala
200-300 mg/kg
CATS
Oral (base) Ascarids (Toxocara, Toxascaris) 100-200 mg/kg
CATTLE
Oral (base) Gastrointestinal roundworms 110-300 mg/kg
SHEEP & GOATS
Oral (base) Gastrointestinal roundworms 110-200 mg/kg
SWINE 
Oral (base) Gastrointestinal roundworms 110-200 mg/kg
HORSES
Oral (base) Gastrointestinal roundworms 110-300 mg/kg; rep after 3 weeks if needed
POULTRY
Oral (base) Gastrointestinal roundworms 32 mg/kg in 2 consecutive feed servings, or in the water during 2 days.

DISCLAIMER: Liability is denied for any possible damage or harm to persons, animals or any other goods that could follow the transmission or use of the information, data or recommendations in this site by any site visitor or third parties.

Dosing recommendations for antiparasitics depend on national regulations. National regulatory authorities determine whether a product is approved for a given indication, i.e. use on a particular host at a specific dose and against a specific parasite. Check the labels of the products available in your country for specific information on approved indications.


  • Click here to view the technical summary of this active ingredient
  • Click here to view the safety summary of this active ingredient
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