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Febantel is a broad spectrum anthelmintic effective against roundworms and, depending on the dose, also against some tapeworms (e.g. Moniezia spp) as welll. It is ineffectice against flukes (e.g. Fasciola hepatica adults) at the usual therapeutic dose. It is completele ineffective against external parasites. Oral administration is the rule.

It is used moderately in dogs and cats (mostly in tablets, pills, etc. or oral suspensions) often mixed with other anthelmintics. Usage in cattle, sheep, swine and horses is more modest (often in feed additives). It is not used in crop protection.

In ruminants, a 50% reduction of the diet 36 prior and 8 hours after treatment slows down the passage through the stomach, which increases the bioavailability of benzimidazoles and their metabolites and consequently its efficacy against gastrointestinal parasites.

In carnivores (incl. dogs and cats) delivery with the food increases the bioavailability of all benzimidazoles resulting in a better efficacy.

All benzimidazoles have almost no residual effect, i.e. they kill the parasites during a few hours after treatment but offer no significant protection against re-infestation.

Unfortunately, resistance of gastrointestinal roundworms to all benzimidazoles in sheep, goats, cattle and horses is a major problem in numerous countries. Not so yet in pets.

The table below indicates some usual dosing recommendations for febantel issued by manufacturers or documented in the scientific literature. They may not be approved in some countries.

Dosing recommendations for FEBANTEL
DOGS
Delivery Parasites Dose (against febantel-susceptible parasites)
Oral Gastrointestianl roundworms 10-25 mg/kg/day x3 days
Oral Toxocara canis
10 mg/kg/day
Oral Ancylostoma spp, Uncinaria spp
15 mg/kg
Oral  Trichuris vulpis 15 mg/kg
CATS
Delivery Parasites Dose (against febantel-susceptible parasites)
Oral Gastrointestianl roundworms 10 mg/kg
CATTLE
Delivery Parasites Dose (against febantel-susceptible parasites)
Oral Gastrointestianl roundworms 7.5-10 mg/kg
Oral Dictyocaulus viviparus 5 mg/kg
Oral Moniezia spp 7.5 mg/kg
Oral Ostertagia ostertagi inhibited larvae 10 mg/kg
SHEEP & GOATS
Delivery Parasites  Dose (against febantel-susceptible parasites)
Oral Gastrointestianl roundworms 5 mg/kg
Oral Protostrongylus rufescens 10 mg/kg
Oral Moniezia spp 5 mg/kg
SWINE 
Delivery Parasites  Dose (against febantel-susceptible parasites)
Oral Gastrointestianl roundworms 5 mg/kg; or 30 ppm (=mg/kg) in feed for 5 days
HORSES
Delivery Parasites  Dose (against febantel-susceptible parasites)
Oral Gastrointestianl roundworms 6 mg/kg
POULTRY
Delivery Parasites Dose (against febantel-susceptible parasites)
Oral Gastrointestianl roundworms 120 ppm (=mg/kg) in feed during 6 days

DISCLAIMER: Liability is denied for any possible damage or harm to persons, animals or any other goods that could follow the transmission or use of the information, data or recommendations in this site by any site visitor or third parties.

Dosing recommendations for antiparasitics depend on national regulations. National regulatory authorities determine whether a product is approved for a given indication, i.e. use on a particular host at a specific dose and against a specific parasite. Check the labels of the products available in your country for specific information on approved indications.


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