Niclosamide is an antiparasitic active ingredient used in veterinary and human medicine. It is used mainly against tapeworms of dogs, cats, horses and livestock. It is also used in agriculture against snails. It belongs to the chemical class of the salicylanilides.
Niclosamide is a narrow-spectrum anthelmintic effective against some tapeworm and fluke species. It is rather scarcely used both in livestock and pets, mostly in oral drenches in combination with a nematicide (e.g. benzimidazoles, levamisole, etc.).
Niclosamide has almost no residual effect, i.e. it kills the parasites during a few hours after treatment but offers no significant protection against re-infestation.
The table below indicates some usual dosing recommendations for niclosamide issued by manufacturers or documented in the scientific literature. They may not be approved in some countries.
|Dosing recommendations for NICLOSAMIDE
|Delivery||Parasites||Dose (against niclosamide-susceptible parasites)
|Oral||Taenia spp||100-150 mg/kg|
|Oral||Tapeworms (general)||50-70 mg/kg|
|Oral||Paramphistomum spp||160 mg/kg, rep after 3 days|
|SHEEP & GOATS|
|Oral||Tapeworms (general)||50 mg/kg|
|Oral||Paramphistomum spp||100 mg/kg (only against intestinal stages)|
|Oral||Anaplocephala spp||200-300 mg/kg|
|Oral||Tapeworms (general)||100-200 mg/kg, rep after 7 days|
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Dosing recommendations for antiparasitics depend on national regulations. National regulatory authorities determine whether a product is approved for a given indication, i.e. use on a particular host at a specific dose and against a specific parasite. Check the labels of the products available in your country for specific information on approved indications.