Brand: PETARMOR ® PRO ADVANCE
FORMULATION: «spot-on» solution for topical administration on the back of the animals (also called pipettes, squeeze-ons, drop-ons, etc.)
- FIPRONIL: 60.1 mg/mL (=6.01%)
- PERMETHRIN: 448.8 mg/mL for dogs and puppies (=48.88%)
CHEMICAL CLASS of the active ingredient(s):
- Fipronil: PHENYLPYRAZOLE
- Permethrin: SYNTHETIC PYRETHROID
PARASITES CONTROLLED* (spectrum of activity)
- Chewing lice (Trichodectes canis)
* Can be slightly different in some countries: read the product label!
- Dogs, small 5 to 10 kg = 11 to 22.9 lbs. bw: 1 pipette with 1.0 mL (equivalent 12.0 - 6.0 fipronil and 89.8 - 44.9 mg/kg permethrin)
- Dogs, medium 10 to 20 kg ≈23 to 44.9 lbs. bw: 1 pipette with 2.0 mL (equivalent to 12.0 - 6.0 mg/kg fipronil and 89.8 - 44.9 mg/kg permethrin)
- Dogs, large 20 to 40 kg ≈45 to 88.9 lbs. bw: 1 pipette with 4.0 mL (equivalent to 12.0 - 6.0 mg/kg fipronil and 89.8 - 44.9 mg/kg permethrin)
- Dogs, very large 40 to 60 kg ≈89 to 132 lbs. bw: 1 pipette with 6.0 mL (equivalent to 9.0 - 6.0 mg/kg fipronil and 67.3 - 44.9 mg/kg permethrin)
* Can be slightly different in some countries: read the product label!
- LD50 (acute oral) in rats: ~960 mg/kg (based on permethrin LD50; MSD not found)
- Estimated Toxicity Class according to the WHO: II moderately hazardous (based on the LD50, learn more)
Suspected poisoning? Read the articles on fipronil safety and/or permethrin safety in this site.
WARNING !!!: Never use on cats: permethrin is toxic to cats! Never use on small dogs pipettes approved for large dogs. Learn more about spot-ons and their safety.
You may be interested in the following articles in this site dealing with the general safety of veterinary products:
- Safety for humans
- Safety for domestic animals
- Safety for the environment
- Hazard classifications of pesticides
Risk of resistance? YES, low to moderate in:
- fleas, mainly the cat flea, Ctenocephalides felis
- brown dog ticks, Rhipicephalus sanguineus
So far there are only very few confirmed reports on flea resistance to fipronil, 25 years after its introduction for flea control. But there are rumors that the number of product failures is increasing, mainly in the US. Fleas have developed resistance to several other insecticides (e.g. carbamates, organophosphates and pyrethroids) and are certainly capable of becoming resistant to fipronil as well. Experience shows that prolonged and uninterrupted use of any insecticide on fleas (including fripronil) bears the risk of resistance development. Flea resistance to pyrethroids is widepread worldwide.
There are no reports on resistance of brown dog ticks to fipronil, but moderate resistance to pyrethroids has been reported in several countries (e.g. Brazil, Panama, Spain, USA).
Resistance of mosquitoes to pyrethroids is widespread worldwide, including in the USA. This is mostly not due to the use of pyrethroids on pets, but to large scale spraying of pyrethroids for vector control or pest control in agriculture. As a consequence protection provided by this product against mosquitoes may be lower or shorter than expected.
Alternatives to prevent resistance through product rotation:
- Amitraz (T*): toxic to cats!
- Carbamates (F+T*), e.g. carbaryl, propoxur
- Indoxacarb (F*)
- Insect Development Inhibitors (F*), e.g. lufenuron
- Isoxazolines (F+T*), e.g. afoxolaner, fluralaner, sarolaner
- Macrocyclic lactones (F*), e.g. selamectin
- Neonicotinoids (F*), e.g. dinotefuran, imidacloprid, nitenpyram
- Organophosphates (F+T*), e.g. chlorpyrifos, coumaphos, diazinon, fenthion, etc.
- Spinosyns (F*), e.g. spinetoram, spinosad
*F = effective against fleas; T = effective against ticks.
These alternative products may not be available in all countries, or may not be available as spot-ons.
Resistance of fleas, brown dog ticks, and mosquitoes to carbamates, organophosphates and pyrethroids is not uncommon in several countries, including the USA.
Learn more about resistance and how it develops.
Are the active ingredients ORIGINAL* or GENERICS**?
- Fipronil: GENERIC (introduced in the 1990s)
- Permethrin: GENERIC (introduced in the 1970s)
*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.
COUNTRIES where this product is marketed (maybe under another TM): USA
GENERIC BRANDS available? YES, numerous, with a more or less comparable composition.
Click here to learn more about GENERIC vs. ORIGINAL drugs.
PETARMOR PRO ADVANCE is a generic fipronil+ brand of FIDOPHARM (i.e. fipronil mixed with something else). It is only for dogs because permethrin is toxic to cats.
Administered about every 4 weeks fipronil controls established flea infestations and prevents flea populations to develop in the pets environment, but only if all the dogs and cats in the same household are treated against fleas. It also kills several tick species (e.g. Dermacentor spp, Ixodes spp, Rhipicephalus sanguineus, Amblyomma americanum, etc).
Fipronil is a phenylpyrazole introduced in the late 1980s (by RHÔNE-MÉRIEUX → MERIAL). It is a broad-spectrum non-systemic insecticide and acaricide massively used in pets and in agriculture, also moderately used in ruminants and against household pests. There are hundreds of products with generic fipronil worldwide. It is effective against ticks, fleas and certain lice species of dogs.
Permethrin is a veteran synthetic pyrethroid introduced in the 1970s (by several companies). It is also a broad-spectrum non-systemic insecticide and acaricide massively used in pets, livestock, hygiene and agriculture worldwide. There are thousands of products with permethrin world-wide. It is also effective against ticks, fleas and certain lice species of dogs, but has also a certain repellent effect against mosquitoes, ticks and flies. However, resistance of these parasites to permethrin and other pyrethroids is not uncommon, in the USA and elsewhere. This means that protection against these parasites due to permethrin may be lower or shorter than expected, particularly against mosquitoes, because the fipronil in the formulation does not contribute to their control.
The combination of two active ingredients of different chemical classes makes theoretically sense regarding resistance prevention in fleas and ticks, because it means attacking fleas through two different mechanisms of action, which is vastly assumed to help preventing or at least delaying resistance development.
Nowadays, after fipronil lost patent protection there are dozens of flea spot-ons for dogs and cats with generic fipronil, alone or in several mixtures with other active ingredients (e.g. pyrethroids, juvenile hormone analogues, amitraz, etc). But not all the brands are available in all countries.
Topical products (mainly spot-ons and insecticide-impregnated collars) have some advantages over systemic products (mainly tablets for oral administration and injectables):
- Most topical products kill or sterilize the parasites before they bite and suck blood on the pet, whereas systemic products kill or sterilize the parasites only after their blood meal.
- Topical products cannot be vomited.
- Spot-ons and collars are very convenient to administer.
- There is a larger choice of topical products.
But topical products have also some disadvantages:
- Topical products contaminate the pet's hair coat and it is advisable for children and also adults to avoid contact with the pet for several days after treatment.
- Topical products may not control parasites in some parts of the pet's body (e.g. the ears, below the tail, between the legs, etc.), whereas systemic products reach the blood-sucking parasites through the blood wherever they are.
- Efficacy of topical products may be reduced or shortened through exposure to dirt, sun, shampooing, washing, rain, baths, etc., whereas efficacy of systemic products is independent from these factors.
This product is one of many examples of a questionable practice regarding the use of pyrethroids at very high concentrations on pets, mainly on dogs. Photostable pyrethroids (including permethrin, cypermethrin, deltamethrin, cyphenothrin, phenothrin, etc.) can have a dose-dependent irritant effect on mammals. Most of them are toxic to cats at the therapeutic dose used on dogs. This is a well-known problem in livestock. Ready-to-use pour-ons are frequently used on cattle, comparable to ready-to-use spot-ons por dogs, but usually at a concentration of 1%-5% active ingredient and at a much lower dose of 1-5 mg/kg. Even at this dose some cattle show signs of irritation, particularly dairy cows and calves. In this particular dog spot-on permethrin is delivered at a concentration of 44.88%, which for small dogs (e.g. 5 kg) results in a dose rate of up to 89.8 mg/kg, almost 100 times more than on cattle. It is not surprising that not all dogs tolerate such a dose, particularly small breeds, puppies and weaker animals (sick, stressed, old).
A comparable situation occurs with amitraz for dogs (and cats, to which amitraz is also toxic). There are no amitraz ready-to-use pour-ons for cattle, because cattle just don't tolerate it at high concentrations. Instead there are topical amitraz sprays or dips that are applied to cattle at concentrations of ~0.025% (250 ppm = mg/L), which results in a dose of 3-5 mg/kg body weight. Even at this dose cattle may not tolerate amitraz and show undesirable side-effects (sedation, depression, etc). Spot-ons for dogs may contain up to 10% amitraz and can result in doses of up to 45 mg/kg body weight! Chihuahuas and puppies are particularly at risk of amitraz side-effects.
It is also not surprising that such products erroneously administered to cats can be deadly.
In fact, serious problems with adverse reactions after use of certain spot-ons have been reported in the USA, especially on cats and small dogs. According to a report by the EPA from 2010, most problems occurred with spot-ons containing permethrin, phenothrin, cyphenothrin (all are synthetic pyrethroids) and amitraz, not approved for use on cats but erroneously used on them. There have been also numerous overdosing cases of small dogs, apparently because some users buy large vials for large dogs but use them several times in smaller dogs to save money. It seems also that small dogs are more sensitive than large ones and don't tolerate the treatment as well as large ones. It also seems that some insufficiently investigated inert ingredients (e.g. solvents) in the formulations are not as harmless as they were supposed to be.
Deeper information on the misuse of synthetic pyrethroids in dogs and pets can be found in: Anadón et al. 2009. Use and abuse of pyrethrins and synthetic pyrethroids in veterinary medicine. The Veterinary Journal, 182, 7-20.
My personal opinion is that the fierce competition for market share in this largest and most profitable veterinary market has pushed some companies to take too many risks in order to launch products that are "different" to those of their competitors. In fact it has become very difficult to be "new" or really "superior" in a market driven mainly by generic active ingredients during the last decade. Once one company has taken the risk, others will follow and launch their "me-too" brand, to be sure they don't miss an opportunity.
For an overview and a list of the most popular pet antiparasitics for flea, tick, lice and/or mite control click here.
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