Oxfendazole is a broad-spectrum anthelmintic effective against roundworms and, depending on the dose also against some tapeworms (e.g. Moniezia spp) as well. It is ineffective against flukes (e.g. Fasciola hepatica adults) and against external parasites. Oral administration is the rule. It is used moderately in livestock (mainly in drenches) and horses (mostly in oral pastes & gels) but very scarcely in pets.
In ruminants, a 50% reduction of the diet 36 prior and 8 hours after treatment slows down the passage through the stomach, which increases the bioavailability of benzimidazoles and their metabolites and consequently its efficacy against gastrointestinal parasites.
In carnivores (incl. dogs and cats) delivery with the food increases the bioavailability of all benzimidazoles resulting in a better efficacy.
All benzimidazoles have almost no residual effect, i.e. they kill the parasites during a few hours after treatment but offer no significant protection against re-infestation.
The table below indicates some usual dosing recommendations for oxfendazole issued by manufacturers or documented in the scientific literature. They may not be approved in some countries.
Dosing recommendations for OXFENDAZOLE |
||
DOGS | ||
Delivery | Parasites | Dose (against oxfendazole-susceptible parasites) |
Oral | Gastrointestianl roundworms | 10 mg/kg/day x3 days |
Oral | Toxocara canis, somatic larvae |
100 mg/kg/day from day 30 of pregnancy until birth |
Oral | Ancylostoma caninum, somatic larvae | 100 mg/kg/day from day 30 of pregnancy until birth |
Oral | Filaroides osleri | 10 mg/kg/day x28 days |
Oral | Trichuris vulpis | 10 mg/kg/day x3 days |
CATS | ||
Delivery | Parasites | Dose (against oxfendazole-susceptible parasites) |
Oral | Ollulanus tricuspis | 10 mg/kg 2x/day x3 days |
CATTLE | ||
Delivery | Parasites | Dose (against oxfendazole-susceptible parasites) |
Oral | Gastrointestinal roundworms | 4.5-5 mg/kg |
Oral | Ostertagia ostertagi inhibited larvae | 5-6.75 mg/kg |
Oral | Dictyocaulus viviparus | 2.5-5 mg/kg |
Oral | Moniezia spp | 5 mg/kg |
SHEEP | ||
Delivery | Parasites | Dose (against oxfendazole-susceptible parasites) |
Oral | Gastrointestinal roundworms | 4.5-5 mg/kg |
Oral | Dictyocaulus filaria | 4.5-5 mg/kg |
Oral | Moniezia spp | 4.5-5 mg/kg |
GOATS | ||
Delivery | Parasites | Dose (against oxfendazole-susceptible parasites) |
Oral | Gastrointestinal roundworms | 7.5 mg/kg |
Oral | Muellerius capillaris | 10 mg/kg |
SWINE | ||
Delivery | Parasites | Dose (against oxfendazole-susceptible parasites) |
Oral | Gastrointestinal roundworms | 3-4.5 mg/kg |
Oral | Ascaris suum | 3 mg/kg |
Oral | Metastrongylus spp | 4.5 mg/kg |
Oral | Trichuris suis | 9 mg/kg |
HORSES | ||
Delivery | Parasites | Dose (against oxfendazole-susceptible parasites) |
Oral | Gastrointestinal roundworms | 10 mg/kg; rep after 48 hours if needed |
Oral | Oxyuris equi | 1.1 mg/kg |
Oral | Strongylus spp (migrating larvae) |
10 mg/kg; rep after 48 hours if needed |
Oral | Thelazia lacrimalis | 10 mg/kg; rep after 48 hours if needed |
SOUTH AMERICAN CAMELIDS | ||
Delivery | Parasites | Dose (against oxfendazole-susceptible parasites) |
Oral | Gastrointestinal roundworms | 5 mg/kg |
DISCLAIMER: Liability is denied for any possible damage or harm to persons, animals or any other goods that could follow the transmission or use of the information, data or recommendations in this site by any site visitor or third parties.
Dosing recommendations for antiparasitics depend on national regulations. National regulatory authorities determine whether a product is approved for a given indication, i.e. use on a particular host at a specific dose and against a specific parasite. Check the labels of the products available in your country for specific information on approved indications.
- Click here to view the technical summary of this active ingredient
- Click here to view the safety summary of this active ingredient
- Click here to view the list of all technical summaries of antiparasitic active ingredients in this site.