Brand: KILTIX ®
Company: ELANCO (BAYER)
CHEMICAL CLASS of the active ingredient(s):
PARASITES CONTROLLED* (spectrum of activity)
* Can be slightly different in some countries: read the product label!
Collars of different sizes according to the dog's weight.
Since the active ingredients are released slowly from the collar's matrix, it is not possible to calculate the exact dose that the animals are exposed to in a particular moment.
- LD50 (acute oral) in rats: >2000 mg/kg (estimate according to MSDS)
- LD50 (acute dermal) in rats: >5000 mg/kg (estimate according to MSDS)
- Estimated Toxicity Class according to the WHO: III slightly hazardous (based on the LD50, learn more)
WARNING !!!: Never use on cats collars approved only for dogs. Learn more about insecticide-impregnated collars and their safety.
You may be interested in the following articles in this site dealing with the general safety of veterinary products:
- Safety for humans
- Safety for domestic animals
- Safety for the environment
- Hazard classifications of pesticides
Risk of resistance? YES, moderate in:
There are reports on resistance of fleas and brown dog ticks (Rhipicephalus sanguineus) to carbamates, with cross-resistance to organophosphates as well as to synthetic pyrethroids. For this reason efficacy and protection provided by this product against these parasites may be lower or shorter than expected.
Alternatives to prevent resistance through product rotation:
- Amitraz (T*): toxic to cats!
- Indoxacarb (F*)
- Insect Development Inhibitors (F*), e.g. lufenuron
- Isoxazolines (F+T*), e.g. afoxolaner, fluralaner, sarolaner
- Macrocyclic lactones (F*), e.g. selamectin
- Neonicotinoids (F*), e.g. dinotefuran, imidacloprid, nitenpyram
- Organophosphates (F+T*), e.g. chlorpyrifos, coumaphos, diazinon, fenthionn, etc.
- Phenylpyrazoles (F+T*), e.g. fipronil, pyriprole
- Spinosyns (F*), e.g. spinetoram, spinosad
*F = effective against fleas; T = effective against ticks.
These alternative products may not be available in all countries, or may not be available as collars.
Are the active ingredients of this product ORIGINAL* or GENERICS**?
- Propoxur: GENERIC (introduced in the 1970s)
- Flumethrin: GENERIC (introduced in the 1980s)
*Meaning that they are still patent protected and generics are not yet available
**Meaning that they have lost patent protection and may be acquired from manufacturers of generic active ingredients other than the holder of the original patent.
COUNTRIES where this product is marketed (maybe under another TM): UK and other countries of the EU, Australia, etc.
GENERIC BRANDS available? NO, in this particular composition
Click here to learn more about GENERIC vs. ORIGINAL drugs.
Propoxur is a veteran broad-spectrum non-systemic carbamate pesticide introduced in the 1970s (by BAYER). It was abundantly used in pets and livestock until the 1980s, but since then has been largely replaced by more modern insecticides. It is still used in topical products for pets (shampoos, soaps, sprays, powders, etc.). It is also used in agriculture and in domestic pesticides.
Flumethrin is a braod-spectrum non-systemic synthetic pyrethroid pesticide introduced in the 1980s (by BAYER). It is probably the best tickicide among all the synthetic pyrethroids, but not very powerful against fleas. It was vastly used in livestock until tick resistance became widespread in the 2000s. Usage in pets was very scarce but has significantly increased in the last years.
In Australia KILTIX has a 5 month-protection label claim against brown dog ticks (Rhipicephalus sanguineus) and bush ticks (Haemaphysalis longicornis) and 6 weeks against paralysis ticks (Ixodes holocyclus). In some European countries it has a 7 month-protection claim against fleas and ticks (Ixodes ricinus, Rhipicephalus sanguineus).
However, due to resistance efficacy and protection against fleas or brown dog ticks may be lower than expected.
- Most topical products kill or sterilize the parasites before they bite and suck blood on the pet, whereas systemic products kill or sterilize the parasites only after their blood meal.
- Topical products cannot be vomited.
- Spot-ons and collars are very convenient to administer.
- There is a larger choice of topical products.
But topical products have also some disadvantages:
- Topical products contaminate the pet's hair coat and it is advisable for children and also adults to avoid contact with the pet for several days after treatment.
- Topical products may not control parasites in some parts of the pet's body (e.g. the ears, below the tail, between the legs, etc.), whereas systemic products reach the blood-sucking parasites through the blood wherever they are.
- Efficacy of topical products may be reduced or shortened through exposure to dirt, sun, shampooing, washing, rain, baths, etc., whereas efficacy of systemic products is independent from these factors.
For an overview and a list of the most popular pet antiparasitics for flea, tick, lice and/or mite control click here.
This article IS NOT A PRODUCT LABEL. It offers complementary information that may be useful to veterinary professionals and users that are not familiar with veterinary antiparasitics.
Information offered in this article has been extracted from publications issued by manufacturers, government agencies (e.g. EMEA, FDA, USDA, etc.) or in the scientific literature. No guarantee is given on its accuracy, integrity, sufficiency, actuality and opportunity, and any liability is denied. Read the site's DISCLAIMER.
In case of doubt contact the manufacturer or a veterinary professional.